BACKGROUND: Individuals infected by human immunodeficiency virus (HIV) have a higher risk of cardiovascular disease than the general population. The specific effects of virological and immunological parameters on the risk of myocardial infarction (MI) in HIV-infected individuals are debated. METHODS: We conducted a nested case-control study within the French Hospital Database on HIV. Case patients (n = 289) were patients who, between January 2000 and December 2006, had a prospectively recorded and validated first MI. Up to 5 HIV-infected controls (n = 884) matched for age, sex, and clinical center were selected, at random with replacement, among patients with no history of MI. Conditional logistic regression models were used to identify predictors of the risk of MI. RESULTS: Plasma HIV-1 RNA levels >50 copies/mL, a low CD4 T-cell nadir, and a high CD8 T-cell count were independently associated with an increased risk of MI, with respective odds ratios of 1.51 (95% confidence interval, 1.09-2.10), 0.90 (.83-.97) per log(2) unit, and 1.48 (1.01-2.18) for the highest tertile of CD8 T-cell counts (>1150 cells/mm(3)) compared with the lowest (≤760 cells/mm(3)). CONCLUSIONS: Independently of cardiovascular risk factors and antiretroviral therapy, HIV replication, a low CD4 T-cell nadir and a high current CD8 T-cell count are associated with an increased risk of MI in HIV-infected individuals. This suggests new paths for interventions to diminish the risk of MI in HIV-infected patients.
BACKGROUND: Individuals infected by human immunodeficiency virus (HIV) have a higher risk of cardiovascular disease than the general population. The specific effects of virological and immunological parameters on the risk of myocardial infarction (MI) in HIV-infected individuals are debated. METHODS: We conducted a nested case-control study within the French Hospital Database on HIV. Case patients (n = 289) were patients who, between January 2000 and December 2006, had a prospectively recorded and validated first MI. Up to 5 HIV-infected controls (n = 884) matched for age, sex, and clinical center were selected, at random with replacement, among patients with no history of MI. Conditional logistic regression models were used to identify predictors of the risk of MI. RESULTS: Plasma HIV-1 RNA levels >50 copies/mL, a low CD4 T-cell nadir, and a high CD8 T-cell count were independently associated with an increased risk of MI, with respective odds ratios of 1.51 (95% confidence interval, 1.09-2.10), 0.90 (.83-.97) per log(2) unit, and 1.48 (1.01-2.18) for the highest tertile of CD8 T-cell counts (>1150 cells/mm(3)) compared with the lowest (≤760 cells/mm(3)). CONCLUSIONS: Independently of cardiovascular risk factors and antiretroviral therapy, HIV replication, a low CD4 T-cell nadir and a high current CD8 T-cell count are associated with an increased risk of MI in HIV-infected individuals. This suggests new paths for interventions to diminish the risk of MI in HIV-infectedpatients.
Authors: Brittanny M Polanka; Suman Kundu; Kaku A So-Armah; Matthew S Freiberg; Samir K Gupta; Roger J Bedimo; Matthew J Budoff; Adeel A Butt; Chung-Chou H Chang; Stephen S Gottlieb; Vincent C Marconi; Julie A Womack; Jesse C Stewart Journal: J Acquir Immune Defic Syndr Date: 2019-05-01 Impact factor: 3.731
Authors: Jessica L Castilho; Bryan E Shepherd; John Koethe; Megan Turner; Sally Bebawy; James Logan; William B Rogers; Stephen Raffanti; Timothy R Sterling Journal: AIDS Date: 2016-03-27 Impact factor: 4.177
Authors: Margalida Rotger; Tracy R Glass; Thomas Junier; Jens Lundgren; James D Neaton; Estella S Poloni; Angélique B van 't Wout; Rubin Lubomirov; Sara Colombo; Raquel Martinez; Andri Rauch; Huldrych F Günthard; Jacqueline Neuhaus; Deborah Wentworth; Danielle van Manen; Luuk A Gras; Hanneke Schuitemaker; Laura Albini; Carlo Torti; Lisa P Jacobson; Xiuhong Li; Lawrence A Kingsley; Federica Carli; Giovanni Guaraldi; Emily S Ford; Irini Sereti; Colleen Hadigan; Esteban Martinez; Mireia Arnedo; Lander Egaña-Gorroño; Jose M Gatell; Matthew Law; Courtney Bendall; Kathy Petoumenos; Jürgen Rockstroh; Jan-Christian Wasmuth; Kabeya Kabamba; Marc Delforge; Stephane De Wit; Florian Berger; Stefan Mauss; Mariana de Paz Sierra; Marcelo Losso; Waldo H Belloso; Maria Leyes; Antoni Campins; Annalisa Mondi; Andrea De Luca; Ignacio Bernardino; Mónica Barriuso-Iglesias; Ana Torrecilla-Rodriguez; Juan Gonzalez-Garcia; José R Arribas; Iuri Fanti; Silvia Gel; Jordi Puig; Eugenia Negredo; Mar Gutierrez; Pere Domingo; Julia Fischer; Gerd Fätkenheuer; Carlos Alonso-Villaverde; Alan Macken; James Woo; Tara McGinty; Patrick Mallon; Alexandra Mangili; Sally Skinner; Christine A Wanke; Peter Reiss; Rainer Weber; Heiner C Bucher; Jacques Fellay; Amalio Telenti; Philip E Tarr Journal: Clin Infect Dis Date: 2013-03-26 Impact factor: 9.079