BACKGROUND: To evaluate changes in diffusion tensor imaging (DTI)-derived parameters in patients with hydrocephalus (HC) before and several weeks after shunt surgery. METHODS: Thirteen HC patients were examined with DTI before and after shunt surgery. In a combined region of interest and whole brain voxel-based analysis, different DTI parameters were compared with an age-matched control group. RESULTS: Alteration of DTI parameters in HC patients and changes after shunt surgery are regionally different. HC patients show an increase in fractional anisotropy values based on increases in parallel diffusivity in the corticospinal tract. On the other hand, reduced fractional anisotropy values are found in the corpus callosum of HC patients. Following shunt surgery, all DTI parameters showed a trend towards normalization, yet differences to healthy control subjects remained. CONCLUSION: Our results show that DTI parameter changes are regionally dependent and need a careful interpretation of the underlying diffusivities to serve as a diagnostic or follow-up measure in patients with hydrocephalus.
BACKGROUND: To evaluate changes in diffusion tensor imaging (DTI)-derived parameters in patients with hydrocephalus (HC) before and several weeks after shunt surgery. METHODS: Thirteen HC patients were examined with DTI before and after shunt surgery. In a combined region of interest and whole brain voxel-based analysis, different DTI parameters were compared with an age-matched control group. RESULTS: Alteration of DTI parameters in HC patients and changes after shunt surgery are regionally different. HC patients show an increase in fractional anisotropy values based on increases in parallel diffusivity in the corticospinal tract. On the other hand, reduced fractional anisotropy values are found in the corpus callosum of HC patients. Following shunt surgery, all DTI parameters showed a trend towards normalization, yet differences to healthy control subjects remained. CONCLUSION: Our results show that DTI parameter changes are regionally dependent and need a careful interpretation of the underlying diffusivities to serve as a diagnostic or follow-up measure in patients with hydrocephalus.
Authors: Weihong Yuan; Karen Harpster; Blaise V Jones; Joshua S Shimony; Robert C McKinstry; Nicole Weckherlin; Stephanie S Powell; Holly Barnard; Jack Engsberg; Darren S Kadis; Jonathan Dodd; Mekibib Altaye; David D Limbrick; Scott K Holland; Sarah M Simpson; Sarah Bidwell; Francesco T Mangano Journal: Neuropediatrics Date: 2016-07-20 Impact factor: 1.947
Authors: Albert M Isaacs; Joshua S Shimony; Diego M Morales; Leandro Castaneyra-Ruiz; Alexis Hartman; Madison Cook; Christopher D Smyser; Jennifer Strahle; Matthew D Smyth; Yan Yan; James P McAllister; Robert C McKinstry; David D Limbrick Journal: J Neurosurg Pediatr Date: 2019-07-19 Impact factor: 2.375
Authors: Daniel Woo; Andrew J Kruger; Padmini Sekar; Mary Haverbusch; Jennifer Osborne; Charles J Moomaw; Sharyl Martini; Shahla M Hosseini; Simona Ferioli; Bradford B Worrall; Mitchell S V Elkind; Gene Sung; Michael L James; Fernando D Testai; Carl D Langefeld; Joseph P Broderick; Sebastian Koch; Matthew L Flaherty Journal: Neurology Date: 2016-02-05 Impact factor: 9.910
Authors: Francesco T Mangano; Mekibib Altaye; Robert C McKinstry; Joshua S Shimony; Stephanie K Powell; Jannel M Phillips; Holly Barnard; David D Limbrick; Scott K Holland; Blaise V Jones; Jonathan Dodd; Sarah Simpson; Deanna Mercer; Akila Rajagopal; Sarah Bidwell; Weihong Yuan Journal: J Neurosurg Pediatr Date: 2016-05-20 Impact factor: 2.375
Authors: Ramin Eskandari; Osama Abdullah; Cameron Mason; Kelley E Lloyd; Amanda N Oeschle; James P McAllister Journal: Childs Nerv Syst Date: 2014-07-29 Impact factor: 1.475