| Literature DB >> 22609199 |
Toshihiko Sakurai1, Vladimir N Bilim, Andrey V Ugolkov, Kaori Yuuki, Masaaki Tsukigi, Teiichi Motoyama, Yoshihiko Tomita.
Abstract
We investigated a prognostic significance and the mechanism of aberrant nuclear expression of EZH2, a histone methyltransferase, in human renal cell carcinoma (RCC). We found nuclear EZH2 in 48 of 100 RCCs and it was significantly correlated with worse survival in RCC patients. We detected a decreased expression of miR-101 in 15 of 54 RCCs. We found that re-expression of miR-101 resulted in EZH2 depletion and decreased renal cancer cell proliferation. Our results show nuclear EZH2 as a prognostic marker of worse survival in human RCC, and identify miR-101 as a negative regulator of EZH2 expression and renal cancer cell proliferation.Entities:
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Year: 2012 PMID： 22609199 DOI： 10.1016/j.bbrc.2012.05.035
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575