Literature DB >> 28469971

Alpinumisoflavone suppresses tumour growth and metastasis of clear-cell renal cell carcinoma.

Tingting Wang1, Yuhua Jiang2, Lei Chu2, Tianhui Wu3, Jie You1.   

Abstract

Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer. The present study is aimed to investigate the role of alpinumisoflavone (AIF), a naturally occurring flavonoid compound, in ccRCC and the underlying mechanism. In this study, miR-101 has been identified as a novel therapeutic target, which exerts anti-tumor effect on ccRCC by directly targeting RLIP76. Moreover, our results showed that AIF was able to increase the expression of miR-101 by suppressing Akt signalling. Our findings in this study provided experimental evidence that AIF has the potential to be used as an agent in the treatment of ccRCC.

Entities:  

Keywords:  Alpinumisoflavone; RLIP76; clear cell renal cell carcinoma; miR-101

Year:  2017        PMID： 28469971      PMCID： PMC5411806     

Source DB:  PubMed          Journal:  Am J Cancer Res        ISSN： 2156-6976            Impact factor:   6.166


  47 in total

1.  Alpinumisoflavone induces apoptosis and suppresses extracellular signal-regulated kinases/mitogen activated protein kinase and nuclear factor-κB pathways in lung tumor cells.

Authors:  Sim Namkoong; Tack-Joong Kim; Ik-Soon Jang; Keon-Wook Kang; Won-Keun Oh; Junsoo Park
Journal:  Biol Pharm Bull       Date:  2011       Impact factor: 2.233

2.  Antibacterial activity of flavonoids from the stem bark of Erythrina caffra thunb.

Authors:  J C Chukwujekwu; F R Van Heerden; J Van Staden
Journal:  Phytother Res       Date:  2011-01       Impact factor: 5.878

3.  HSF-1 interacts with Ral-binding protein 1 in a stress-responsive, multiprotein complex with HSP90 in vivo.

Authors:  Yanzhong Hu; Nahid F Mivechi
Journal:  J Biol Chem       Date:  2003-03-05       Impact factor: 5.157

4.  microRNA-133b downregulation and inhibition of cell proliferation, migration and invasion by targeting matrix metallopeptidase-9 in renal cell carcinoma.

Authors:  Deyao Wu; Huixing Pan; Yunfeng Zhou; Jian Zhou; Yuanfeng Fan; Ping Qu
Journal:  Mol Med Rep       Date:  2014-04-04       Impact factor: 2.952

5.  The follow-up management of non-metastatic renal cell carcinoma: definition of a surveillance protocol.

Authors:  Alessandro Antonelli; Alberto Cozzoli; Danilo Zani; Tiziano Zanotelli; Maria Nicolai; Sergio Cosciani Cunico; Claudio Simeone
Journal:  BJU Int       Date:  2007-02       Impact factor: 5.588

6.  Vascular mimicry formation is promoted by paracrine TGF-β and SDF1 of cancer-associated fibroblasts and inhibited by miR-101 in hepatocellular carcinoma.

Authors:  Jine Yang; Yang Lu; Ying-Ying Lin; Zhi-Yuan Zheng; Jian-Hong Fang; Shuai He; Shi-Mei Zhuang
Journal:  Cancer Lett       Date:  2016-09-28       Impact factor: 8.679

7.  MicroRNA-218 inhibits cell migration and invasion in renal cell carcinoma through targeting caveolin-2 involved in focal adhesion pathway.

Authors:  Takeshi Yamasaki; Naohiko Seki; Hirofumi Yoshino; Toshihiko Itesako; Hideo Hidaka; Yasutoshi Yamada; Shuichi Tatarano; Tomokazu Yonezawa; Takashi Kinoshita; Masayuki Nakagawa; Hideki Enokida
Journal:  J Urol       Date:  2013-02-27       Impact factor: 7.450

8.  Cytotoxicity of seven naturally occurring phenolic compounds towards multi-factorial drug-resistant cancer cells.

Authors:  Victor Kuete; Armelle T Mbaveng; Eric C N Nono; Christophe C Simo; Maen Zeino; Augustin E Nkengfack; Thomas Efferth
Journal:  Phytomedicine       Date:  2016-04-27       Impact factor: 5.340

9.  MicroRNA-101 regulated transcriptional modulator SUB1 plays a role in prostate cancer.

Authors:  B V S K Chakravarthi; M T Goswami; S S Pathi; A D Robinson; M Cieślik; D S Chandrashekar; S Agarwal; J Siddiqui; S Daignault; S L Carskadon; X Jing; A M Chinnaiyan; L P Kunju; N Palanisamy; S Varambally
Journal:  Oncogene       Date:  2016-06-06       Impact factor: 9.867

10.  Site-specific associations between miRNA expression and survival in colorectal cancer cases.

Authors:  Martha L Slattery; Jennifer S Herrick; Daniel F Pellatt; Lila E Mullany; John R Stevens; Erica Wolff; Michael D Hoffman; Roger K Wolff; Wade Samowitz
Journal:  Oncotarget       Date:  2016-09-13
View more
  6 in total

Review 1.  Potential of Central, Eastern and Western Africa Medicinal Plants for Cancer Therapy: Spotlight on Resistant Cells and Molecular Targets.

Authors:  Armelle T Mbaveng; Victor Kuete; Thomas Efferth
Journal:  Front Pharmacol       Date:  2017-06-02       Impact factor: 5.810

Review 2.  Phytochemicals for the Prevention and Treatment of Renal Cell Carcinoma: Preclinical and Clinical Evidence and Molecular Mechanisms.

Authors:  Essa M Bajalia; Farah B Azzouz; Danielle A Chism; Derrek M Giansiracusa; Carina G Wong; Kristina N Plaskett; Anupam Bishayee
Journal:  Cancers (Basel)       Date:  2022-07-04       Impact factor: 6.575

Review 3.  The Role of Compounds Derived from Natural Supplement as Anticancer Agents in Renal Cell Carcinoma: A Review.

Authors:  Inamul Haque; Arvind Subramanian; Chao H Huang; Andrew K Godwin; Peter J Van Veldhuizen; Snigdha Banerjee; Sushanta K Banerjee
Journal:  Int J Mol Sci       Date:  2017-12-31       Impact factor: 5.923

Review 4.  Systematic Review of Potential Anticancerous Activities of Erythrina senegalensis DC (Fabaceae).

Authors:  Souleymane Fofana; Moussa Ouédraogo; Rafaèle Calvo Esposito; Windbedema Prisca Ouedraogo; Cédric Delporte; Pierre Van Antwerpen; Véronique Mathieu; Innocent Pierre Guissou
Journal:  Plants (Basel)       Date:  2021-12-22

5.  Alpinumisoflavone attenuates lipopolysaccharide-induced acute lung injury by regulating the effects of anti-oxidation and anti-inflammation both in vitro and in vivo.

Authors:  Pei-Ying Li; Yu-Chia Liang; Ming-Jyh Sheu; Shyh-Shyun Huang; Che-Yi Chao; Yueh-Hsiung Kuo; Guan-Jhong Huang
Journal:  RSC Adv       Date:  2018-09-07       Impact factor: 4.036

6.  Alpinumisoflavone ameliorates choroidal neovascularisation and fibrosis in age-related macular degeneration in in vitro and in vivo models.

Authors:  Eunhye Yu; Yunjeong Song; Sun Mi Gu; Yang Hee Jo; Sang Won Yeon; Kyu Jin Han; Mi Kyeong Lee; Jung Kee Min; Jaesuk Yun
Journal:  Sci Rep       Date:  2022-08-22       Impact factor: 4.996
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.