OBJECTIVE: To estimate the contribution of 9 obesity-related polymorphisms and a genetic predisposition score (GPS) on anthropometric and biochemical variables before and after a weight loss intervention program in overweight/obese Spanish adolescents. STUDY DESIGN: Overweight/obese adolescents (n = 168; 12-16 years) participating in the EVASYON program were genotyped for 9 obesity-related single nucleotide polymorphisms in the FTO, MC4R, TMEM18, IL6, PPARG, and ADIPQ genes. RESULTS: At baseline, the GPS showed a significant association with body mass index-standard deviation score (BMI-SDS) and fat mass. After 3 months of intervention, this GPS also showed a relationship with the variation of both anthropometric measurements. After adjusting for baseline BMI-SDS, subjects with a lower GPS had a greater improvement on metabolic profile, as well as a better response to physical activity, compared with those subjects with a higher GPS. CONCLUSIONS: The GPS seems to have an important relationship with BMI-SDS and fat mass both at baseline and after a 3-month weight loss lifestyle intervention. Obese and overweight adolescents with a lower GPS have a greater benefit of weight loss after 3 months of a multidisciplinary lifestyle intervention.
OBJECTIVE: To estimate the contribution of 9 obesity-related polymorphisms and a genetic predisposition score (GPS) on anthropometric and biochemical variables before and after a weight loss intervention program in overweight/obese Spanish adolescents. STUDY DESIGN: Overweight/obese adolescents (n = 168; 12-16 years) participating in the EVASYON program were genotyped for 9 obesity-related single nucleotide polymorphisms in the FTO, MC4R, TMEM18, IL6, PPARG, and ADIPQ genes. RESULTS: At baseline, the GPS showed a significant association with body mass index-standard deviation score (BMI-SDS) and fat mass. After 3 months of intervention, this GPS also showed a relationship with the variation of both anthropometric measurements. After adjusting for baseline BMI-SDS, subjects with a lower GPS had a greater improvement on metabolic profile, as well as a better response to physical activity, compared with those subjects with a higher GPS. CONCLUSIONS: The GPS seems to have an important relationship with BMI-SDS and fat mass both at baseline and after a 3-month weight loss lifestyle intervention. Obese and overweight adolescents with a lower GPS have a greater benefit of weight loss after 3 months of a multidisciplinary lifestyle intervention.
Authors: Melanie Heitkamp; Monika Siegrist; Sophie Molnos; Stefan Brandmaier; Simone Wahl; Helmut Langhof; Harald Grallert; Martin Halle Journal: JAMA Pediatr Date: 2021-01-04 Impact factor: 16.193
Authors: Alisa Weiland; Lena Kasemann Nannette; Stephan Zipfel; Stefan Ehehalt; Katrin Ziser; Florian Junne; Isabelle Mack Journal: Front Public Health Date: 2022-03-25
Authors: Lukas Zlatohlavek; Vit Maratka; Eva Tumova; Richard Ceska; Vera Lanska; Michal Vrablik; Jaroslav A Hubacek Journal: Med Sci Monit Date: 2018-10-20