BACKGROUND: In genome-wide association studies (GWAS) of human life span, none of the genetic variants has reached the level of genome-wide statistical significance. The roles of such variants in life span regulation remain unclear. DATA AND METHOD: A biodemographic analyses was done of genetic regulation of life span using data on low-significance longevity alleles selected in the earlier GWAS of the original Framingham cohort. RESULTS: Age-specific survival curves considered as functions of the number of longevity alleles exhibit regularities known in demography as "rectangularization" of survival curves. The presence of such pattern confirms observations from experimental studies that regulation of life span involves genes responsible for stress resistance. CONCLUSION: Biodemographic analyses could provide important information about the properties of genes affecting phenotypic traits.
BACKGROUND: In genome-wide association studies (GWAS) of human life span, none of the genetic variants has reached the level of genome-wide statistical significance. The roles of such variants in life span regulation remain unclear. DATA AND METHOD: A biodemographic analyses was done of genetic regulation of life span using data on low-significance longevity alleles selected in the earlier GWAS of the original Framingham cohort. RESULTS: Age-specific survival curves considered as functions of the number of longevity alleles exhibit regularities known in demography as "rectangularization" of survival curves. The presence of such pattern confirms observations from experimental studies that regulation of life span involves genes responsible for stress resistance. CONCLUSION: Biodemographic analyses could provide important information about the properties of genes affecting phenotypic traits.
Authors: Anne B Newman; Stefan Walter; Kathryn L Lunetta; Melissa E Garcia; P Eline Slagboom; Kaare Christensen; Alice M Arnold; Thor Aspelund; Yurii S Aulchenko; Emelia J Benjamin; Lene Christiansen; Ralph B D'Agostino; Annette L Fitzpatrick; Nora Franceschini; Nicole L Glazer; Vilmundur Gudnason; Albert Hofman; Robert Kaplan; David Karasik; Margaret Kelly-Hayes; Douglas P Kiel; Lenore J Launer; Kristin D Marciante; Joseph M Massaro; Iva Miljkovic; Michael A Nalls; Dena Hernandez; Bruce M Psaty; Fernando Rivadeneira; Jerome Rotter; Sudha Seshadri; Albert V Smith; Kent D Taylor; Henning Tiemeier; Hae-Won Uh; André G Uitterlinden; James W Vaupel; Jeremy Walston; Rudi G J Westendorp; Tamara B Harris; Thomas Lumley; Cornelia M van Duijn; Joanne M Murabito Journal: J Gerontol A Biol Sci Med Sci Date: 2010-03-18 Impact factor: 6.053
Authors: Stefan Walter; Gil Atzmon; Ellen W Demerath; Melissa E Garcia; Robert C Kaplan; Meena Kumari; Kathryn L Lunetta; Yuri Milaneschi; Toshiko Tanaka; Gregory J Tranah; Uwe Völker; Lei Yu; Alice Arnold; Emelia J Benjamin; Reiner Biffar; Aron S Buchman; Eric Boerwinkle; David Couper; Philip L De Jager; Denis A Evans; Tamara B Harris; Wolfgang Hoffmann; Albert Hofman; David Karasik; Douglas P Kiel; Thomas Kocher; Maris Kuningas; Lenore J Launer; Kurt K Lohman; Pamela L Lutsey; Johan Mackenbach; Kristin Marciante; Bruce M Psaty; Eric M Reiman; Jerome I Rotter; Sudha Seshadri; Michelle D Shardell; Albert V Smith; Cornelia van Duijn; Jeremy Walston; M Carola Zillikens; Stefania Bandinelli; Sebastian E Baumeister; David A Bennett; Luigi Ferrucci; Vilmundur Gudnason; Mika Kivimaki; Yongmei Liu; Joanne M Murabito; Anne B Newman; Henning Tiemeier; Nora Franceschini Journal: Neurobiol Aging Date: 2011-07-22 Impact factor: 4.673
Authors: Joris Deelen; Marian Beekman; Hae-Won Uh; Quinta Helmer; Maris Kuningas; Lene Christiansen; Dennis Kremer; Ruud van der Breggen; H Eka D Suchiman; Nico Lakenberg; Erik B van den Akker; Willemijn M Passtoors; Henning Tiemeier; Diana van Heemst; Anton J de Craen; Fernando Rivadeneira; Eco J de Geus; Markus Perola; Frans J van der Ouderaa; David A Gunn; Dorret I Boomsma; André G Uitterlinden; Kaare Christensen; Cornelia M van Duijn; Bastiaan T Heijmans; Jeanine J Houwing-Duistermaat; Rudi G J Westendorp; P Eline Slagboom Journal: Aging Cell Date: 2011-05-06 Impact factor: 9.304
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Authors: Anatoliy I Yashin; Konstantin G Arbeev; Liubov S Arbeeva; Deqing Wu; Igor Akushevich; Mikhail Kovtun; Arseniy Yashkin; Alexander Kulminski; Irina Culminskaya; Eric Stallard; Miaozhu Li; Svetlana V Ukraintseva Journal: Biogerontology Date: 2015-08-18 Impact factor: 4.277
Authors: Daniel W Belsky; Avshalom Caspi; Renate Houts; Harvey J Cohen; David L Corcoran; Andrea Danese; HonaLee Harrington; Salomon Israel; Morgan E Levine; Jonathan D Schaefer; Karen Sugden; Ben Williams; Anatoli I Yashin; Richie Poulton; Terrie E Moffitt Journal: Proc Natl Acad Sci U S A Date: 2015-07-06 Impact factor: 11.205
Authors: Konstantin G Arbeev; Igor Akushevich; Alexander M Kulminski; Svetlana V Ukraintseva; Anatoliy I Yashin Journal: Front Public Health Date: 2014-11-06
Authors: Anatoliy I Yashin; Deqing Wu; Konstantin Arbeev; Arseniy P Yashkin; Igor Akushevich; Olivia Bagley; Matt Duan; Svetlana Ukraintseva Journal: J Transl Genet Genom Date: 2021-10-19
Authors: Anatoliy I Yashin; Deqing Wu; Liubov S Arbeeva; Konstantin G Arbeev; Alexander M Kulminski; Igor Akushevich; Mikhail Kovtun; Irina Culminskaya; Eric Stallard; Miaozhu Li; Svetlana V Ukraintseva Journal: Front Genet Date: 2015-04-13 Impact factor: 4.599