Literature DB >> 22605713

Ethylene glycol ingestion masked by concomitant ethanol intoxication.

Justin M Head1.   

Abstract

An obtunded male with a history of alcohol abuse presented to the emergency department with metabolic acidosis, an osmolar gap and lactic acidosis. The patient was initially treated for alcohol intoxication due to an extremely high blood alcohol level. Following respiratory failure and intubation, a large volume of dark green liquid was removed via nasogastric suction; bedside fluorescence for ethylene glycol was negative. Twenty-four hours later, the patient's glomerular filtration rate decreased significantly, serum osmolality was 807, the osmolar gap was 407, complete metabolic panel showed pH of 6.8, sodium of 156 mmol/l, potassium of 7.3 mmol/l, chloride of 116, CO(2) of 3.9 and anion gap of 30.7. Blood lactic acid was >56 mmol/l. The patient received emergency haemodialysis. Four days after presentation, the patient began to respond to voice commands and was extubated. Currently, the patient still receives haemodialysis due to ongoing renal failure, but no long-term neurologic complications are evident.

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Year:  2012        PMID: 22605713      PMCID: PMC3316865          DOI: 10.1136/bcr.12.2011.5326

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  10 in total

Review 1.  Treatment of the alcohol intoxications: ethylene glycol, methanol and isopropanol.

Authors:  S Abramson; A K Singh
Journal:  Curr Opin Nephrol Hypertens       Date:  2000-11       Impact factor: 2.894

Review 2.  Ethylene glycol poisoning: case report of a record-high level and a review.

Authors:  D P Davis; K J Bramwell; R S Hamilton; S R Williams
Journal:  J Emerg Med       Date:  1997 Sep-Oct       Impact factor: 1.484

3.  Glycolate kinetics and hemodialysis clearance in ethylene glycol poisoning. META Study Group.

Authors:  C L Moreau; W Kerns; C A Tomaszewski; K E McMartin; S R Rose; M D Ford; J Brent
Journal:  J Toxicol Clin Toxicol       Date:  1998

4.  American Academy of Clinical Toxicology Practice Guidelines on the Treatment of Ethylene Glycol Poisoning. Ad Hoc Committee.

Authors:  D G Barceloux; E P Krenzelok; K Olson; W Watson
Journal:  J Toxicol Clin Toxicol       Date:  1999

5.  Toxicokinetics of ethylene glycol during fomepizole therapy: implications for management. For the Methylpyrazole for Toxic Alcohols Study Group.

Authors:  M L Sivilotti; M J Burns; K E McMartin; J Brent
Journal:  Ann Emerg Med       Date:  2000-08       Impact factor: 5.721

6.  A visual schematic for clarifying the temporal relationship between the anion and osmol gaps in toxic alcohol poisoning.

Authors:  Mark B Mycyk; Steven E Aks
Journal:  Am J Emerg Med       Date:  2003-07       Impact factor: 2.469

7.  Ethylene glycol poisoning: experiences from an epidemic in Sweden.

Authors:  C Karlson-Stiber; H Persson
Journal:  J Toxicol Clin Toxicol       Date:  1992

8.  Ethylene glycol poisoning presenting with a falsely elevated lactate level.

Authors:  Sandra Verelst; Pieter Vermeersch; Koen Desmet
Journal:  Clin Toxicol (Phila)       Date:  2009-03       Impact factor: 4.467

9.  Organic acids in ethylene glycol intoxication.

Authors:  P A Gabow; K Clay; J B Sullivan; R Lepoff
Journal:  Ann Intern Med       Date:  1986-07       Impact factor: 25.391

Review 10.  Toxic alcohol ingestions: clinical features, diagnosis, and management.

Authors:  Jeffrey A Kraut; Ira Kurtz
Journal:  Clin J Am Soc Nephrol       Date:  2007-11-28       Impact factor: 8.237

  10 in total
  1 in total

Review 1.  Toxic alcohol diagnosis and management: an emergency medicine review.

Authors:  Patrick Chow Yuen Ng; Brit J Long; William Tyler Davis; Daniel J Sessions; Alex Koyfman
Journal:  Intern Emerg Med       Date:  2018-02-09       Impact factor: 3.397

  1 in total

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