OBJECTIVES: The aim of this study was to investigate whether exposure to a range of relatively low concentrations of aged secondhand smoke (SHS), similar to those encountered commonly in the community, would impair endothelial function in a concentration-dependent manner. BACKGROUND: Exposure to SHS impairs endothelial function in humans. The concentration-dependent relationship for aged SHS effects on endothelial function after an exposure of short duration is unknown. METHODS: Thirty-three healthy nonsmokers were exposed to 1 of 2 low levels of aged SHS or to conditioned filtered air for 30 min. The primary end point was change in maximal percent brachial artery flow-mediated dilation after exposure. RESULTS: In a linear regression model for each increase in SHS exposure by 100 μg/m(3) respirable suspended particles, the absolute maximal percent brachial artery flow-mediated dilation was reduced by 0.67%. We did not find evidence of a threshold for the effect of SHS on flow-mediated dilation. CONCLUSIONS: Short-term exposure to real-world levels of aged SHS for 30 min resulted in a concentration-dependent decrease in endothelial function as measured by flow-mediated dilation.
OBJECTIVES: The aim of this study was to investigate whether exposure to a range of relatively low concentrations of aged secondhand smoke (SHS), similar to those encountered commonly in the community, would impair endothelial function in a concentration-dependent manner. BACKGROUND: Exposure to SHS impairs endothelial function in humans. The concentration-dependent relationship for aged SHS effects on endothelial function after an exposure of short duration is unknown. METHODS: Thirty-three healthy nonsmokers were exposed to 1 of 2 low levels of aged SHS or to conditioned filtered air for 30 min. The primary end point was change in maximal percent brachial artery flow-mediated dilation after exposure. RESULTS: In a linear regression model for each increase in SHS exposure by 100 μg/m(3) respirable suspended particles, the absolute maximal percent brachial artery flow-mediated dilation was reduced by 0.67%. We did not find evidence of a threshold for the effect of SHS on flow-mediated dilation. CONCLUSIONS: Short-term exposure to real-world levels of aged SHS for 30 min resulted in a concentration-dependent decrease in endothelial function as measured by flow-mediated dilation.
Authors: Kranthi Pinnamaneni; Richard E Sievers; Rikki Sharma; Amanda M Selchau; Gustavo Gutierrez; Eric J Nordsieck; Robert Su; Songtao An; Qiumei Chen; Xiaoyin Wang; Ronak Derakhshandeh; Kirstin Aschbacher; Christian Heiss; Stanton A Glantz; Suzaynn F Schick; Matthew L Springer Journal: Nicotine Tob Res Date: 2013-12-03 Impact factor: 4.244
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Authors: Neil E Klepeis; Narinder Dhaliwal; Gary Hayward; Viviana Acevedo-Bolton; Wayne R Ott; Nathan Read; Steve Layton; Ruoting Jiang; Kai-Chung Cheng; Lynn M Hildemann; James L Repace; Stephanie Taylor; Seow-Ling Ong; Francisco O Buchting; Juliet P Lee; Roland S Moore Journal: Int J Environ Res Public Health Date: 2016-01-20 Impact factor: 3.390