Janet Wei1, Chrisandra Shufelt, Eveline Oestreicher Stock, Claire Mills, Shivani Dhawan, Riya Jacob, Tina Torbati, Galen Cook-Wiens, Neal Benowitz, Peyton Jacob, Peter Ganz, Cathleen Noel Bairey Merz, Rita Redberg. 1. Barbra Streisand Women's Heart Center, Cedars-Sinai Heart Institute (Drs Wei, Shufelt, Ms Dhawan, Ms Torbati, Dr Bairey Merz); Flight Attendant Medical Research Institute (FAMRI) Bland Lane Center of Excellence on Second Hand Smoke (Dr Oestreicher Stock, Ms Jacob, Dr Benowitz, Mr Jacob, Dr Redberg); Division of Cardiology, Center of Excellence in Vascular Research at the San Francisco General Hospital (Ms Mills, Dr Ganz); Biostatistics and Bioinformatics Core (Mr Cook-Wiens), Cedars-Sinai Medical Center, Los Angeles; University of California, San Francisco Center for Tobacco Control Research and Education Tobacco Centers of Regulatory Science (TCORS) (Dr Ganz); and Division of Cardiology, Department of Medicine (Drs Oestreicher Stock, Redberg), University of California, San Francisco, San Francisco, California.
Abstract
OBJECTIVE: To determine whether early vascular aging may be present in flight attendants with remote in-cabin secondhand smoke (SHS) exposure. METHODS: Twenty-six flight attendants with a history of in-cabin SHS exposure prior to the airline smoking bans were recruited. Pulse wave analysis, peripheral arterial tonometry, and brachial artery reactivity testing evaluated their arterial compliance and endothelial function. RESULTS: Flight attendants with remote in-cabin SHS exposure have normal blood pressure, pulse wave velocity, and reactive hyperemia index, but abnormal pulse pressure, augmentation index, flow-mediated dilation, and hyperemic mean flow ratio. CONCLUSION: These preliminary findings suggest that flight attendants with remote in-cabin SHS exposure have preclinical signs of accelerated vascular aging and raise new questions about the relationship between remote SHS exposure and vascular health.
OBJECTIVE: To determine whether early vascular aging may be present in flight attendants with remote in-cabin secondhand smoke (SHS) exposure. METHODS: Twenty-six flight attendants with a history of in-cabin SHS exposure prior to the airline smoking bans were recruited. Pulse wave analysis, peripheral arterial tonometry, and brachial artery reactivity testing evaluated their arterial compliance and endothelial function. RESULTS: Flight attendants with remote in-cabin SHS exposure have normal blood pressure, pulse wave velocity, and reactive hyperemia index, but abnormal pulse pressure, augmentation index, flow-mediated dilation, and hyperemic mean flow ratio. CONCLUSION: These preliminary findings suggest that flight attendants with remote in-cabin SHS exposure have preclinical signs of accelerated vascular aging and raise new questions about the relationship between remote SHS exposure and vascular health.
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