| Literature DB >> 22595312 |
Dongkook Park1, Xiaowen Hou, Jonathan V Sweedler, Paul H Taghert.
Abstract
Bioactive peptides are important therapeutic drugs, yet conventional methods of peptide synthesis are challenged to meet increasing demand. We developed a novel and efficient means of metabolic engineering: therapeutic peptide production in Drosophila and as a proof of concept, we demonstrate production of fully matured human insulin. This in vivo system offers an innovative means to produce valuable bioactive peptides for therapies, its inherent flexibility facilitates drug development, and its ease of producing fully processed peptides simplifies metabolic engineering of new peptide products.Entities:
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Year: 2012 PMID： 22595312 PMCID： PMC3402651 DOI： 10.1016/j.peptides.2012.05.003
Source DB: PubMed Journal: Peptides ISSN： 0196-9781 Impact factor: 3.750