Literature DB >> 2259298

Is Gompertzian or exponential kinetics a valid description of individual human cancer growth?

M W Retsky1, D E Swartzendruber, R H Wardwell, P D Bame.   

Abstract

It is generally accepted that human cancers grow in an exponential or Gompertzian manner. This assumption is based on analysis of the growth of transplantable animal tumors and on averages of tumor growth in human populations. A computer model of breast cancer in individual patients has raised some doubts about this assumption. The computer model predicts an irregular pattern of tumor growth that incorporates plateaus or dormant periods separated by Gompertzian growth spurts. Since growth patterns involving plateaus are not predicted by conventionally accepted exponential or Gompertzian kinetics, sufficient documentation of their existence may be regarded as some evidence that the computer model is correct. The literature has been surveyed to identify growth patterns specifically predicted by the model. The literature contains clinical evidence from individual patients of this growth pattern in primary breast, large intestine and rectum, and pulmonary cancers and metastatic pulmonary cancer. Much data, including the only breast data, are not consistent with exponential or Gompertzian kinetics but are explainable by irregular growth kinetics. Exponential growth is valid for some tumors and for short times, but there are many papers citing significant deviations from that growth. Exponential growth may accurately describe averages of human tumor growth and growth of multipassaged experimental tumors, but it is not valid for all individual tumors.

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Year:  1990        PMID: 2259298     DOI: 10.1016/0306-9877(90)90186-i

Source DB:  PubMed          Journal:  Med Hypotheses        ISSN: 0306-9877            Impact factor:   1.538


  29 in total

1.  Breast Cancer: A Revolutionary Concept.

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Journal:  Breast Cancer       Date:  1995-04-30       Impact factor: 4.239

2.  Realistic simulation of the 3-D growth of brain tumors in MR images coupling diffusion with biomechanical deformation.

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Journal:  IEEE Trans Med Imaging       Date:  2005-10       Impact factor: 10.048

3.  In vivo growth of 60 non-screening detected lung cancers: a computed tomography study.

Authors:  Onno M Mets; Kaman Chung; Pieter Zanen; Ernst T Scholten; Wouter B Veldhuis; Bram van Ginneken; Mathias Prokop; Cornelia M Schaefer-Prokop; Pim A de Jong
Journal:  Eur Respir J       Date:  2018-04-12       Impact factor: 16.671

Review 4.  The dynamics of drug resistance: a mathematical perspective.

Authors:  Orit Lavi; Michael M Gottesman; Doron Levy
Journal:  Drug Resist Updat       Date:  2012-03-03       Impact factor: 18.500

5.  Modeling the effect of tumor size in early breast cancer.

Authors:  Claire Verschraegen; Vincent Vinh-Hung; Gábor Cserni; Richard Gordon; Melanie E Royce; Georges Vlastos; Patricia Tai; Guy Storme
Journal:  Ann Surg       Date:  2005-02       Impact factor: 12.969

6.  Early postoperative growth in non-functioning pituitary adenomas; A tool to tailor safe follow-up.

Authors:  Kristin Astrid Øystese; Manuela Zucknick; Olivera Casar-Borota; Geir Ringstad; Jens Bollerslev
Journal:  Endocrine       Date:  2017-05-17       Impact factor: 3.633

7.  Front instabilities and invasiveness of simulated avascular tumors.

Authors:  Nikodem J Popławski; Ubirajara Agero; J Scott Gens; Maciej Swat; James A Glazier; Alexander R A Anderson
Journal:  Bull Math Biol       Date:  2009-02-21       Impact factor: 1.758

8.  Lower mitotic activity in BRCA1/2-associated primary breast cancers occurring after risk-reducing salpingo-oophorectomy.

Authors:  Victorien Mt van Verschuer; Bernadette Am Heemskerk-Gerritsen; Carolien Hm van Deurzen; Inge-Marie Obdeijn; Madeleine Ma Tilanus-Linthorst; Cornelis Verhoef; Marjanka K Schmidt; Linetta B Koppert; Maartje J Hooning; Caroline Seynaeve
Journal:  Cancer Biol Ther       Date:  2014-01-14       Impact factor: 4.742

9.  New concepts in breast cancer emerge from analyzing clinical data using numerical algorithms.

Authors:  Michael Retsky
Journal:  Int J Environ Res Public Health       Date:  2009-01-20       Impact factor: 3.390

10.  Colon-targeted delivery of live bacterial cell biotherapeutics including microencapsulated live bacterial cells.

Authors:  Satya Prakash; Aleksandra Malgorzata Urbanska
Journal:  Biologics       Date:  2008-09
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