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Literature DB >> 22589387

The structural basis of DKK-mediated inhibition of Wnt/LRP signaling.

Abstract

Low-density lipoprotein receptor-related proteins 5 and 6 (LRP5/6) mediate canonical Wnt-β-catenin signaling by forming a complex with the co-receptor Frizzled, which binds to Wnt proteins. Dickkopf (DKK)-related proteins inhibit the Wnt signaling pathway by directly binding to the ectodomains of LRP5/6. However, the mechanism for DKK-mediated antagonism has not been fully understood as of yet. Crystal structures of the LRP6 ectodomain in complex with DKK1, along with mutagenesis studies, provide considerable insights into the molecular basis for DKK-mediated inhibition and Wnt signaling through LRP5/6.

Entities: Chemical Disease Gene Mutation Species

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Year: 2012 PMID： 22589387 PMCID： PMC3465688 DOI： 10.1126/scisignal.2003028

Source DB: PubMed Journal: Sci Signal ISSN： 1945-0877 Impact factor: 8.192

28 in total

1. LDL-receptor-related protein 6 is a receptor for Dickkopf proteins.

Authors: B Mao; W Wu; Y Li; D Hoppe; P Stannek; A Glinka; C Niehrs
Journal: Nature Date: 2001-05-17 Impact factor: 49.962

Review 2. The Wnt signaling pathway in development and disease.

Authors: Catriona Y Logan; Roel Nusse
Journal: Annu Rev Cell Dev Biol Date: 2004 Impact factor: 13.827

3. Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6.

Authors: M V Semënov; K Tamai; B K Brott; M Kühl; S Sokol; X He
Journal: Curr Biol Date: 2001-06-26 Impact factor: 10.834

Review 4. Wnt/beta-catenin pathway.

Authors: Randall T Moon
Journal: Sci STKE Date: 2005-02-15

5. Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow.

Authors: A Bafico; G Liu; A Yaniv; A Gazit; S A Aaronson
Journal: Nat Cell Biol Date: 2001-07 Impact factor: 28.824

6. Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled.

Authors: Lin Li; Junhao Mao; Le Sun; Wenzhong Liu; Dianqing Wu
Journal: J Biol Chem Date: 2001-12-12 Impact factor: 5.157

7. High bone density due to a mutation in LDL-receptor-related protein 5.

Authors: Lynn M Boyden; Junhao Mao; Joseph Belsky; Lyle Mitzner; Anita Farhi; Mary A Mitnick; Dianqing Wu; Karl Insogna; Richard P Lifton
Journal: N Engl J Med Date: 2002-05-16 Impact factor: 91.245

8. Regulation of Wnt/LRP signaling by distinct domains of Dickkopf proteins.

Authors: Barbara K Brott; Sergei Y Sokol
Journal: Mol Cell Biol Date: 2002-09 Impact factor: 4.272

9. The LRP5 high-bone-mass G171V mutation disrupts LRP5 interaction with Mesd.

Authors: Yazhou Zhang; Yang Wang; Xiaofeng Li; Jianhong Zhang; Junhao Mao; Zhong Li; Jie Zheng; Lin Li; Steve Harris; Dianqing Wu
Journal: Mol Cell Biol Date: 2004-06 Impact factor: 4.272

10. Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling.

Authors: Bingyu Mao; Wei Wu; Gary Davidson; Joachim Marhold; Mingfa Li; Bernard M Mechler; Hajo Delius; Dana Hoppe; Peter Stannek; Carmen Walter; Andrei Glinka; Christof Niehrs
Journal: Nature Date: 2002-05-26 Impact factor: 49.962

31 in total

Review 1. Dickkopf1: An immunomodulatory ligand and Wnt antagonist in pathological inflammation.

Authors: Wook-Jin Chae; Alfred L M Bothwell
Journal: Differentiation Date: 2019-06-12 Impact factor: 3.880

2. Localized Fgf10 expression is not required for lung branching morphogenesis but prevents differentiation of epithelial progenitors.

Authors: Thomas Volckaert; Alice Campbell; Erik Dill; Changgong Li; Parviz Minoo; Stijn De Langhe
Journal: Development Date: 2013-08-07 Impact factor: 6.868

Review 3. LRP receptor family member associated bone disease.

Authors: N Lara-Castillo; M L Johnson
Journal: Rev Endocr Metab Disord Date: 2015-06 Impact factor: 6.514

Review 4. Wnt and FGF mediated epithelial-mesenchymal crosstalk during lung development.

Authors: Thomas Volckaert; Stijn P De Langhe
Journal: Dev Dyn Date: 2014-12-29 Impact factor: 3.780

5. Exome sequencing of two Italian pedigrees with non-isolated Chiari malformation type I reveals candidate genes for cranio-facial development.

Authors: Elisa Merello; Lorenzo Tattini; Alberto Magi; Andrea Accogli; Gianluca Piatelli; Marco Pavanello; Domenico Tortora; Armando Cama; Zoha Kibar; Valeria Capra; Patrizia De Marco
Journal: Eur J Hum Genet Date: 2017-05-17 Impact factor: 4.246

6. LRP4 third β-propeller domain mutations cause novel congenital myasthenia by compromising agrin-mediated MuSK signaling in a position-specific manner.

Authors: Bisei Ohkawara; Macarena Cabrera-Serrano; Tomohiko Nakata; Margherita Milone; Nobuyuki Asai; Kenyu Ito; Mikako Ito; Akio Masuda; Yasutomo Ito; Andrew G Engel; Kinji Ohno
Journal: Hum Mol Genet Date: 2013-11-13 Impact factor: 6.150

Review 7. The role of pericyte detachment in vascular rarefaction.

Authors: Claudia Schrimpf; Omke E Teebken; Mathias Wilhelmi; Jeremy S Duffield
Journal: J Vasc Res Date: 2014-09-03 Impact factor: 1.934

8. The NFκB subunit RELA is a master transcriptional regulator of the committed epithelial-mesenchymal transition in airway epithelial cells.

Authors: Bing Tian; Steven G Widen; Jun Yang; Thomas G Wood; Andrzej Kudlicki; Yingxin Zhao; Allan R Brasier
Journal: J Biol Chem Date: 2018-08-30 Impact factor: 5.157

9. High Bone Mass-Causing Mutant LRP5 Receptors Are Resistant to Endogenous Inhibitors In Vivo.

Authors: Paul J Niziolek; Bryan T MacDonald; Rajendra Kedlaya; Minjie Zhang; Teresita Bellido; Xi He; Matthew L Warman; Alexander G Robling
Journal: J Bone Miner Res Date: 2015-10 Impact factor: 6.741

10. Structural architecture and functional evolution of Wnts.

Authors: J Fernando Bazan; Claudia Y Janda; K Christopher Garcia
Journal: Dev Cell Date: 2012-08-14 Impact factor: 12.270