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Literature DB >> 22898770

Structural architecture and functional evolution of Wnts.

J Fernando Bazan¹, Claudia Y Janda, K Christopher Garcia.

Abstract

The crystal structure of a Wnt morphogen bound to its Frizzled receptor ectodomain provides insights into the evolutionary provenance of this complex fold and offers an explanation for why Wnts utilize both lipid- and protein-mediated contacts to engage Frizzleds.

Entities: Chemical

Mesh：

Substances：

Year: 2012 PMID： 22898770 PMCID： PMC3458506 DOI： 10.1016/j.devcel.2012.07.011

Source DB: PubMed Journal: Dev Cell ISSN： 1534-5807 Impact factor: 12.270

51 in total

Review 1. Similarities between the Hedgehog and Wnt signaling pathways.

Authors: Daniel Kalderon
Journal: Trends Cell Biol Date: 2002-11 Impact factor: 20.808

2. The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling.

Authors: Ivan Bosanac; Henry R Maun; Suzie J Scales; Xiaohui Wen; Andreas Lingel; J Fernando Bazan; Frederic J de Sauvage; Sarah G Hymowitz; Robert A Lazarus
Journal: Nat Struct Mol Biol Date: 2009-06-28 Impact factor: 15.369

Review 3. The many faces and functions of β-catenin.

Authors: Tomas Valenta; George Hausmann; Konrad Basler
Journal: EMBO J Date: 2012-05-22 Impact factor: 11.598

4. IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding.

Authors: S G Hymowitz; E H Filvaroff; J P Yin; J Lee; L Cai; P Risser; M Maruoka; W Mao; J Foster; R F Kelley; G Pan; A L Gurney; A M de Vos; M A Starovasnik
Journal: EMBO J Date: 2001-10-01 Impact factor: 11.598

5. Structure of artemin complexed with its receptor GFRalpha3: convergent recognition of glial cell line-derived neurotrophic factors.

Authors: Xinquan Wang; Robert H Baloh; Jeffrey Milbrandt; K Christopher Garcia
Journal: Structure Date: 2006-06 Impact factor: 5.006

6. Crystal structure of the human TbetaR2 ectodomain--TGF-beta3 complex.

Authors: P John Hart; Shashank Deep; Alexander B Taylor; Zhanyong Shu; Cynthia S Hinck; Andrew P Hinck
Journal: Nat Struct Biol Date: 2002-03

7. ConSurf 2010: calculating evolutionary conservation in sequence and structure of proteins and nucleic acids.

Authors: Haim Ashkenazy; Elana Erez; Eric Martz; Tal Pupko; Nir Ben-Tal
Journal: Nucleic Acids Res Date: 2010-05-16 Impact factor: 16.971

Review 8. Vicinal disulfide turns.

Authors: Oliviero Carugo; Masa Cemazar; Sotir Zahariev; Ilona Hudáky; Zoltán Gáspári; András Perczel; Sándor Pongor
Journal: Protein Eng Date: 2003-09

9. Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair.

Authors: Qiang Xu; Yanshu Wang; Alain Dabdoub; Philip M Smallwood; John Williams; Chad Woods; Matthew W Kelley; Li Jiang; William Tasman; Kang Zhang; Jeremy Nathans
Journal: Cell Date: 2004-03-19 Impact factor: 41.582

10. The structure of the NPC1L1 N-terminal domain in a closed conformation.

Authors: Hyock Joo Kwon; Maya Palnitkar; Johann Deisenhofer
Journal: PLoS One Date: 2011-04-15 Impact factor: 3.240

19 in total

Review 1. A Comprehensive Overview of Skeletal Phenotypes Associated with Alterations in Wnt/β-catenin Signaling in Humans and Mice.

Authors: Kevin A Maupin; Casey J Droscha; Bart O Williams
Journal: Bone Res Date: 2013-03-29 Impact factor: 13.567

2. Isolation and characterization of recombinant murine Wnt3a.

Authors: Andrzej Witkowski; Aparna Krishnamoorthy; Betty Su; Jennifer A Beckstead; Robert O Ryan
Journal: Protein Expr Purif Date: 2014-11-08 Impact factor: 1.650

3. Cell signalling: Disarming Wnt.

Authors: Roel Nusse
Journal: Nature Date: 2015-02-25 Impact factor: 49.962

4. Disulfide bond requirements for active Wnt ligands.

Authors: Bryan T MacDonald; Annie Hien; Xinjun Zhang; Oladoyin Iranloye; David M Virshup; Marian L Waterman; Xi He
Journal: J Biol Chem Date: 2014-05-19 Impact factor: 5.157

5. Characterization of secondary structure and lipid binding behavior of N-terminal saposin like subdomain of human Wnt3a.

Authors: Aparna Krishnamoorthy; Andrzej Witkowski; Jesse J Tran; Paul M M Weers; Robert O Ryan
Journal: Arch Biochem Biophys Date: 2017-07-25 Impact factor: 4.013

6. structural Studies of Wnts and identification of an LRP6 binding site.

Authors: Matthew Ling-Hon Chu; Victoria E Ahn; Hee-Jung Choi; Danette L Daniels; Roel Nusse; William I Weis
Journal: Structure Date: 2013-06-20 Impact factor: 5.006

7. Mutations in WNT1 cause different forms of bone fragility.

Authors: Katharina Keupp; Filippo Beleggia; Hülya Kayserili; Aileen M Barnes; Magdalena Steiner; Oliver Semler; Björn Fischer; Gökhan Yigit; Claudia Y Janda; Jutta Becker; Stefan Breer; Umut Altunoglu; Johannes Grünhagen; Peter Krawitz; Jochen Hecht; Thorsten Schinke; Elena Makareeva; Ekkehart Lausch; Tufan Cankaya; José A Caparrós-Martín; Pablo Lapunzina; Samia Temtamy; Mona Aglan; Bernhard Zabel; Peer Eysel; Friederike Koerber; Sergey Leikin; K Christopher Garcia; Christian Netzer; Eckhard Schönau; Victor L Ruiz-Perez; Stefan Mundlos; Michael Amling; Uwe Kornak; Joan Marini; Bernd Wollnik
Journal: Am J Hum Genet Date: 2013-03-14 Impact factor: 11.025