Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Continuous-flow synthesis of activated vitamin D3 and its analogues.

Literature DB >> 22588675

Continuous-flow synthesis of activated vitamin D3 and its analogues.

Shinichiro Fuse¹, Yuto Mifune, Nobutake Tanabe, Takashi Takahashi.

Abstract

An efficient, two-stage, continuous-flow synthesis of 1α,25-(OH)(2)-vitamin D(3) (activated vitamin D(3)) and its analogues was achieved. The developed method afforded the desired products in satisfactory yields using a high-intensity and economical light source, i.e., a high-pressure mercury lamp. In addition, our method required neither intermediate purification nor high-dilution conditions.

Entities: Chemical

Mesh：

Substances：
Cholecalciferol

Year: 2012 PMID： 22588675 DOI： 10.1039/c2ob25511a

Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876

Keyword Cloud
Cited

7 in total

1. Efficient amide bond formation through a rapid and strong activation of carboxylic acids in a microflow reactor.

Authors: Shinichiro Fuse; Yuto Mifune; Takashi Takahashi
Journal: Angew Chem Int Ed Engl Date: 2013-12-02 Impact factor: 15.336

2. Microflow photochemistry: UVC-induced [2 + 2]-photoadditions to furanone in a microcapillary reactor.

Authors: Sylvestre Bachollet; Kimitada Terao; Shin Aida; Yasuhiro Nishiyama; Kiyomi Kakiuchi; Michael Oelgemöller
Journal: Beilstein J Org Chem Date: 2013-10-04 Impact factor: 2.883

Review 3. Microflow High-p,T Intensification of Vitamin D₃ Synthesis Using an Ultraviolet Lamp.

Authors: Marc Escribà-Gelonch; Timothy Noël; Volker Hessel
Journal: Org Process Res Dev Date: 2017-12-20 Impact factor: 3.317

4. Simultaneous Synthesis of Vitamins D₂, D₄, D₅, D₆, and D₇ from Commercially Available Phytosterol, β-Sitosterol, and Identification of Each Vitamin D by HSQC NMR.

Authors: Shiro Komba; Eiichi Kotake-Nara; Wakako Tsuzuki
Journal: Metabolites Date: 2019-06-06

Continuous-flow synthesis of activated vitamin D3 and its analogues.

1. Efficient amide bond formation through a rapid and strong activation of carboxylic acids in a microflow reactor.

2. Microflow photochemistry: UVC-induced [2 + 2]-photoadditions to furanone in a microcapillary reactor.

Review 3. Microflow High-p,T Intensification of Vitamin D₃ Synthesis Using an Ultraviolet Lamp.

4. Simultaneous Synthesis of Vitamins D₂, D₄, D₅, D₆, and D₇ from Commercially Available Phytosterol, β-Sitosterol, and Identification of Each Vitamin D by HSQC NMR.

5. Micro-flow synthesis and structural analysis of sterically crowded diimine ligands with five aryl rings.

Review 6. Synthesis and Biological Activity of Sterol 14α-Demethylase and Sterol C24-Methyltransferase Inhibitors.

Review 7. Continuous Flow Photochemistry for the Preparation of Bioactive Molecules.

Continuous-flow synthesis of activated vitamin D3 and its analogues.

1. Efficient amide bond formation through a rapid and strong activation of carboxylic acids in a microflow reactor.

2. Microflow photochemistry: UVC-induced [2 + 2]-photoadditions to furanone in a microcapillary reactor.

Review 3. Microflow High-p,T Intensification of Vitamin D3 Synthesis Using an Ultraviolet Lamp.

4. Simultaneous Synthesis of Vitamins D2, D4, D5, D6, and D7 from Commercially Available Phytosterol, β-Sitosterol, and Identification of Each Vitamin D by HSQC NMR.

5. Micro-flow synthesis and structural analysis of sterically crowded diimine ligands with five aryl rings.

Review 6. Synthesis and Biological Activity of Sterol 14α-Demethylase and Sterol C24-Methyltransferase Inhibitors.

Review 7. Continuous Flow Photochemistry for the Preparation of Bioactive Molecules.

Review 3. Microflow High-p,T Intensification of Vitamin D₃ Synthesis Using an Ultraviolet Lamp.

4. Simultaneous Synthesis of Vitamins D₂, D₄, D₅, D₆, and D₇ from Commercially Available Phytosterol, β-Sitosterol, and Identification of Each Vitamin D by HSQC NMR.