Literature DB >> 22585990

USP2a activation of MYC in prostate cancer.

William G Nelson1, Angelo M De Marzo, Srinivasan Yegnasubramanian.   

Abstract

Ubiquitin-specific protease 2a, a deubiquitinating enzyme, elevates MYC levels in prostate cancer cells via its stabilization of MDM2, undermining p53 regulation of microRNAs that target MYC mRNA. ©2012 AACR.

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Year:  2012        PMID： 22585990      PMCID： PMC4479124          DOI： 10.1158/2159-8290.CD-12-0027

Source DB:  PubMed          Journal:  Cancer Discov        ISSN： 2159-8274            Impact factor:   39.397


  9 in total

Review 1.  The p53 orchestra: Mdm2 and Mdmx set the tone.

Authors:  Mark Wade; Yunyuan V Wang; Geoffrey M Wahl
Journal:  Trends Cell Biol       Date:  2010-02-19       Impact factor: 20.808

Review 2.  Translating p53 into the clinic.

Authors:  Chit Fang Cheok; Chandra S Verma; José Baselga; David P Lane
Journal:  Nat Rev Clin Oncol       Date:  2010-10-26       Impact factor: 66.675

3.  The isopeptidase USP2a protects human prostate cancer from apoptosis.

Authors:  Carmen Priolo; Dan Tang; Mohan Brahamandan; Barbara Benassi; Ewa Sicinska; Shuji Ogino; Antonella Farsetti; Alessandro Porrello; Stephen Finn; Johann Zimmermann; Phillip Febbo; Massimo Loda
Journal:  Cancer Res       Date:  2006-09-01       Impact factor: 12.701

4.  MYC and Prostate Cancer.

Authors:  Cheryl M Koh; Charles J Bieberich; Chi V Dang; William G Nelson; Srinivasan Yegnasubramanian; Angelo M De Marzo
Journal:  Genes Cancer       Date:  2010-06

5.  MYC overexpression induces prostatic intraepithelial neoplasia and loss of Nkx3.1 in mouse luminal epithelial cells.

Authors:  Tsuyoshi Iwata; Denise Schultz; Jessica Hicks; Gretchen K Hubbard; Laura N Mutton; Tamara L Lotan; Carlise Bethel; Matthew T Lotz; Srinivasan Yegnasubramanian; William G Nelson; Chi V Dang; MengMeng Xu; Uzoma Anele; Cheryl M Koh; Charles J Bieberich; Angelo M De Marzo
Journal:  PLoS One       Date:  2010-02-25       Impact factor: 3.240

6.  The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer.

Authors:  Edgard Graner; Dan Tang; Sabrina Rossi; Antonella Baron; Toshiro Migita; Lisa J Weinstein; Mirna Lechpammer; Dieter Huesken; Johann Zimmermann; Sabina Signoretti; Massimo Loda
Journal:  Cancer Cell       Date:  2004-03       Impact factor: 31.743

7.  Somatic single hits inactivate the X-linked tumor suppressor FOXP3 in the prostate.

Authors:  Lizhong Wang; Runhua Liu; Weiquan Li; Chong Chen; Hiroto Katoh; Guo-Yun Chen; Beth McNally; Lin Lin; Penghui Zhou; Tao Zuo; Kathleen A Cooney; Yang Liu; Pan Zheng
Journal:  Cancer Cell       Date:  2009-10-06       Impact factor: 31.743

8.  MYC is activated by USP2a-mediated modulation of microRNAs in prostate cancer.

Authors:  Barbara Benassi; Richard Flavin; Luigi Marchionni; Silvio Zanata; Yunfeng Pan; Dipanjan Chowdhury; Marina Marani; Sabrina Strano; Paola Muti; Giovanni Blandino; Massimo Loda
Journal:  Cancer Discov       Date:  2012-01-05       Impact factor: 39.397

9.  The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2.

Authors:  Lauren F Stevenson; Alison Sparks; Nerea Allende-Vega; Dimitris P Xirodimas; David P Lane; Mark K Saville
Journal:  EMBO J       Date:  2007-02-08       Impact factor: 11.598
  9 in total
  6 in total

Review 1.  Oxidative stress response and Nrf2 signaling in aging.

Authors:  Hongqiao Zhang; Kelvin J A Davies; Henry Jay Forman
Journal:  Free Radic Biol Med       Date:  2015-06-09       Impact factor: 7.376

2.  Identifying USPs regulating immune signals in Drosophila: USP2 deubiquitinates Imd and promotes its degradation by interacting with the proteasome.

Authors:  Elodie Engel; Perrine Viargues; Magda Mortier; Emmanuel Taillebourg; Yohann Couté; Dominique Thevenon; Marie-Odile Fauvarque
Journal:  Cell Commun Signal       Date:  2014-07-16       Impact factor: 5.712

3.  SPOP regulates prostate epithelial cell proliferation and promotes ubiquitination and turnover of c-MYC oncoprotein.

Authors:  C Geng; S Kaochar; M Li; K Rajapakshe; W Fiskus; J Dong; C Foley; B Dong; L Zhang; O-J Kwon; S S Shah; M Bolaki; L Xin; M Ittmann; B W O'Malley; C Coarfa; N Mitsiades
Journal:  Oncogene       Date:  2017-04-17       Impact factor: 9.867

4.  Imaging-Based Screening of Deubiquitinating Proteases Identifies Otubain-1 as a Stabilizer of c-MYC.

Authors:  Shannon E Moree; Laure Maneix; Polina Iakova; Fabio Stossi; Ergun Sahin; Andre Catic
Journal:  Cancers (Basel)       Date:  2022-02-04       Impact factor: 6.639

Review 5.  Regulation of Cancer Metabolism by Deubiquitinating Enzymes: The Warburg Effect.

Authors:  So-Hee Kim; Kwang-Hyun Baek
Journal:  Int J Mol Sci       Date:  2021-06-08       Impact factor: 5.923

Review 6.  DUBbing Cancer: Deubiquitylating Enzymes Involved in Epigenetics, DNA Damage and the Cell Cycle As Therapeutic Targets.

Authors:  Adan Pinto-Fernandez; Benedikt M Kessler
Journal:  Front Genet       Date:  2016-07-28       Impact factor: 4.599
  6 in total

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