Literature DB >> 22584258

CUL4B ubiquitin ligase in mouse development: a model for human X-linked mental retardation syndrome?

Yongchao Zhao1, Yi Sun.   

Abstract

CUL4B, a member of the cullin-RING ubiquitin ligase family, is frequently mutated in X-linked mental retardation (XLMR) patients. The study by Liu et al. showed that Cul4b plays an essential developmental role in the extra-embryonic tissues, while it is dispensable in the embryo proper during mouse embryogenesis. Viable Cul4b-null mice provide the first animal model to study neuronal and behavioral deficiencies seen in human CUL4B XLMR patients.

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Year:  2012        PMID： 22584258      PMCID： PMC3411174          DOI： 10.1038/cr.2012.79

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  16 in total

1.  Prevalence of mental retardation and developmental disabilities: estimates from the 1994/1995 National Health Interview Survey Disability Supplements.

Authors:  S A Larson; K C Lakin; L Anderson; N Kwak; J H Lee; D Anderson
Journal:  Am J Ment Retard       Date:  2001-05

Review 2.  DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.

Authors:  Jennifer Lee; Pengbo Zhou
Journal:  Mol Cell       Date:  2007-06-22       Impact factor: 17.970

3.  Mutation in CUL4B, which encodes a member of cullin-RING ubiquitin ligase complex, causes X-linked mental retardation.

Authors:  Yongxin Zou; Qiji Liu; Bingxi Chen; Xiyu Zhang; Chenhong Guo; Haibin Zhou; Jiangxia Li; Guimin Gao; Yishou Guo; Chuanzhu Yan; Jianjun Wei; Changshun Shao; Yaoqin Gong
Journal:  Am J Hum Genet       Date:  2007-01-25       Impact factor: 11.025

4.  Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis.

Authors:  Liren Liu; Yan Yin; Yuewei Li; Lisa Prevedel; Elizabeth H Lacy; Liang Ma; Pengbo Zhou
Journal:  Cell Res       Date:  2012-03-27       Impact factor: 25.617

5.  Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor.

Authors:  Patrick S Tarpey; F Lucy Raymond; Sarah O'Meara; Sarah Edkins; Jon Teague; Adam Butler; Ed Dicks; Claire Stevens; Calli Tofts; Tim Avis; Syd Barthorpe; Gemma Buck; Jennifer Cole; Kristian Gray; Kelly Halliday; Rachel Harrison; Katy Hills; Andrew Jenkinson; David Jones; Andrew Menzies; Tatiana Mironenko; Janet Perry; Keiran Raine; David Richardson; Rebecca Shepherd; Alexandra Small; Jennifer Varian; Sofie West; Sara Widaa; Uma Mallya; Jenny Moon; Ying Luo; Susan Holder; Sarah F Smithson; Jane A Hurst; Jill Clayton-Smith; Bronwyn Kerr; Jackie Boyle; Marie Shaw; Lucianne Vandeleur; Jayson Rodriguez; Rachel Slaugh; Douglas F Easton; Richard Wooster; Martin Bobrow; Anand K Srivastava; Roger E Stevenson; Charles E Schwartz; Gillian Turner; Jozef Gecz; P Andrew Futreal; Michael R Stratton; Michael Partington
Journal:  Am J Hum Genet       Date:  2007-01-04       Impact factor: 11.025

Review 6.  Conditional gene targeting in the mouse nervous system: Insights into brain function and diseases.

Authors:  Claire Gavériaux-Ruff; Brigitte L Kieffer
Journal:  Pharmacol Ther       Date:  2007-01-10       Impact factor: 12.310

Review 7.  CRL4s: the CUL4-RING E3 ubiquitin ligases.

Authors:  Sarah Jackson; Yue Xiong
Journal:  Trends Biochem Sci       Date:  2009-10-07       Impact factor: 13.807

8.  CUL4A abrogation augments DNA damage response and protection against skin carcinogenesis.

Authors:  Liren Liu; Sharrell Lee; Jianxuan Zhang; Sara B Peters; Jeffrey Hannah; Yue Zhang; Yan Yin; Andrew Koff; Liang Ma; Pengbo Zhou
Journal:  Mol Cell       Date:  2009-05-14       Impact factor: 17.970

9.  An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer.

Authors:  Teresa A Soucy; Peter G Smith; Michael A Milhollen; Allison J Berger; James M Gavin; Sharmila Adhikari; James E Brownell; Kristine E Burke; David P Cardin; Stephen Critchley; Courtney A Cullis; Amanda Doucette; James J Garnsey; Jeffrey L Gaulin; Rachel E Gershman; Anna R Lublinsky; Alice McDonald; Hirotake Mizutani; Usha Narayanan; Edward J Olhava; Stephane Peluso; Mansoureh Rezaei; Michael D Sintchak; Tina Talreja; Michael P Thomas; Tary Traore; Stepan Vyskocil; Gabriel S Weatherhead; Jie Yu; Julie Zhang; Lawrence R Dick; Christopher F Claiborne; Mark Rolfe; Joseph B Bolen; Steven P Langston
Journal:  Nature       Date:  2009-04-09       Impact factor: 49.962

Review 10.  XLMR genes: update 2007.

Authors:  Pietro Chiurazzi; Charles E Schwartz; Jozef Gecz; Giovanni Neri
Journal:  Eur J Hum Genet       Date:  2008-01-16       Impact factor: 4.246
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  8 in total

1.  CUL4B regulates autophagy via JNK signaling in diffuse large B-cell lymphoma.

Authors:  Ying Li; Xiangxiang Zhou; Ya Zhang; Juan Yang; Yangyang Xu; Yi Zhao; Xin Wang
Journal:  Cell Cycle       Date:  2019-02-01       Impact factor: 4.534

Review 2.  Cullin-RING Ligases as attractive anti-cancer targets.

Authors:  Yongchao Zhao; Yi Sun
Journal:  Curr Pharm Des       Date:  2013       Impact factor: 3.116

3.  Glycogen Synthase Kinase 3β in Pancreatic Cancer and its Implications in Chemotherapy and Radiation Therapy.

Authors:  Qiang Zhang; Mahaveer S Bhojani; Edgar Ben-Josef; Aaron C Spalding; Rork Kuick; Yi Sun; Meredith A Morgan
Journal:  J Carcinog Mutagen       Date:  2013-08-16

4.  CUL4B negatively regulates Toll-like receptor-triggered proinflammatory responses by repressing Pten transcription.

Authors:  Yu Song; Peishan Li; Liping Qin; Zhiliang Xu; Baichun Jiang; Chunhong Ma; Changshun Shao; Yaoqin Gong
Journal:  Cell Mol Immunol       Date:  2019-11-15       Impact factor: 11.530

Review 5.  The Role of the COP9 Signalosome and Neddylation in DNA Damage Signaling and Repair.

Authors:  Dudley Chung; Graham Dellaire
Journal:  Biomolecules       Date:  2015-09-30

6.  De novo PHIP-predicted deleterious variants are associated with developmental delay, intellectual disability, obesity, and dysmorphic features.

Authors:  Emily Webster; Megan T Cho; Nora Alexander; Sonal Desai; Sakkubai Naidu; Mir Reza Bekheirnia; Andrea Lewis; Kyle Retterer; Jane Juusola; Wendy K Chung
Journal:  Cold Spring Harb Mol Case Stud       Date:  2016-11

7.  HUWE1 plays important role in mouse preimplantation embryo development and the dysregulation is associated with poor embryo development in humans.

Authors:  L J Chen; W M Xu; M Yang; K Wang; Y Chen; X J Huang; Q H Ma
Journal:  Sci Rep       Date:  2016-11-30       Impact factor: 4.379

Review 8.  Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases.

Authors:  Weihua Zhou; Wenyi Wei; Yi Sun
Journal:  Cell Res       Date:  2013-03-26       Impact factor: 25.617
  8 in total

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