Literature DB >> 22584051

Perspective: Dynamics of receptor tyrosine kinase signaling complexes.

Bruce J Mayer1.   

Abstract

Textbook descriptions of signal transduction complexes provide a static snapshot view of highly dynamic events. Despite enormous strides in identifying the key components of signaling complexes and the underlying mechanisms of signal transduction, our understanding of the dynamic behavior of these complexes has lagged behind. Using the example of receptor tyrosine kinases, this perspective takes a fresh look at the dynamics of the system and their potential impact on signal processing.
Copyright © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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Year:  2012        PMID： 22584051      PMCID： PMC3413745          DOI： 10.1016/j.febslet.2012.05.002

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  32 in total

1.  Distinct tyrosine autophosphorylation sites negatively and positively modulate neu-mediated transformation.

Authors:  D L Dankort; Z Wang; V Blackmore; M F Moran; W J Muller
Journal:  Mol Cell Biol       Date:  1997-09       Impact factor: 4.272

2.  Membrane clustering and the role of rebinding in biochemical signaling.

Authors:  Andrew Mugler; Aimee Gotway Bailey; Koichi Takahashi; Pieter Rein ten Wolde
Journal:  Biophys J       Date:  2012-03-06       Impact factor: 4.033

3.  Rapid phospho-turnover by receptor tyrosine kinases impacts downstream signaling and drug binding.

Authors:  Laura B Kleiman; Thomas Maiwald; Holger Conzelmann; Douglas A Lauffenburger; Peter K Sorger
Journal:  Mol Cell       Date:  2011-09-02       Impact factor: 17.970

4.  Surface plasmon resonance thermodynamic and kinetic analysis as a strategic tool in drug design. Distinct ways for phosphopeptides to plug into Src- and Grb2 SH2 domains.

Authors:  Nico J de Mol; Frank J Dekker; Isabel Broutin; Marcel J E Fischer; Rob M J Liskamp
Journal:  J Med Chem       Date:  2005-02-10       Impact factor: 7.446

5.  Peroxovanadate induces tyrosine phosphorylation of multiple signaling proteins in mouse liver and kidney.

Authors:  S J Ruff; K Chen; S Cohen
Journal:  J Biol Chem       Date:  1997-01-10       Impact factor: 5.157

Review 6.  Cell signaling by receptor tyrosine kinases.

Authors:  Mark A Lemmon; Joseph Schlessinger
Journal:  Cell       Date:  2010-06-25       Impact factor: 41.582

7.  The Grb2-mSos1 complex binds phosphopeptides with higher affinity than Grb2.

Authors:  Y M Chook; G D Gish; C M Kay; E F Pai; T Pawson
Journal:  J Biol Chem       Date:  1996-11-29       Impact factor: 5.157

8.  Phosphotyrosine signaling: evolving a new cellular communication system.

Authors:  Wendell A Lim; Tony Pawson
Journal:  Cell       Date:  2010-09-03       Impact factor: 41.582

9.  c-Abl kinase regulates the protein binding activity of c-Crk.

Authors:  S M Feller; B Knudsen; H Hanafusa
Journal:  EMBO J       Date:  1994-05-15       Impact factor: 11.598

10.  Molecular machines or pleiomorphic ensembles: signaling complexes revisited.

Authors:  Bruce J Mayer; Michael L Blinov; Leslie M Loew
Journal:  J Biol       Date:  2009-10-16
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  16 in total

1.  The development and application of a quantitative peptide microarray based approach to protein interaction domain specificity space.

Authors:  Brett W Engelmann; Yohan Kim; Miaoyan Wang; Bjoern Peters; Ronald S Rock; Piers D Nash
Journal:  Mol Cell Proteomics       Date:  2014-08-18       Impact factor: 5.911

2.  Palmatine inhibits growth and invasion in prostate cancer cell: Potential role for rpS6/NFκB/FLIP.

Authors:  Heather G Hambright; Izhar Singh Batth; Jianping Xie; Rita Ghosh; Addanki Pratap Kumar
Journal:  Mol Carcinog       Date:  2014-07-07       Impact factor: 4.784

3.  Brain Region and Isoform-Specific Phosphorylation Alters Kalirin SH2 Domain Interaction Sites and Calpain Sensitivity.

Authors:  Megan B Miller; Yan Yan; Kazuya Machida; Drew D Kiraly; Aaron D Levy; Yi I Wu; TuKiet T Lam; Thomas Abbott; Anthony J Koleske; Betty A Eipper; Richard E Mains
Journal:  ACS Chem Neurosci       Date:  2017-04-25       Impact factor: 4.418

4.  De novo design of tyrosine and serine kinase-driven protein switches.

Authors:  Nicholas B Woodall; Zara Weinberg; Jesslyn Park; Florian Busch; Richard S Johnson; Mikayla J Feldbauer; Michael Murphy; Maggie Ahlrichs; Issa Yousif; Michael J MacCoss; Vicki H Wysocki; Hana El-Samad; David Baker
Journal:  Nat Struct Mol Biol       Date:  2021-09-13       Impact factor: 18.361

5.  The GTPase-activating protein p120RasGAP has an evolutionarily conserved "FLVR-unique" SH2 domain.

Authors:  Rachel Jaber Chehayeb; Jessica Wang; Amy L Stiegler; Titus J Boggon
Journal:  J Biol Chem       Date:  2020-06-15       Impact factor: 5.157

6.  SH2-PLA: a sensitive in-solution approach for quantification of modular domain binding by proximity ligation and real-time PCR.

Authors:  Christopher M Thompson; Lee R Bloom; Mari Ogiue-Ikeda; Kazuya Machida
Journal:  BMC Biotechnol       Date:  2015-06-26       Impact factor: 2.563

7.  Crk adaptors negatively regulate actin polymerization in pedestals formed by enteropathogenic Escherichia coli (EPEC) by binding to Tir effector.

Authors:  Elvira Nieto-Pelegrin; Eugenia Meiler; José Manuel Martín-Villa; María Benito-León; Narcisa Martinez-Quiles
Journal:  PLoS Pathog       Date:  2014-03-27       Impact factor: 6.823

Review 8.  Pharmacodynamic and Pharmacokinetic Markers For Anti-angiogenic Cancer Therapy: Implications for Dosing and Selection of Patients.

Authors:  Matteo Morotti; Prashanth Hari Dass; Adrian L Harris; Simon Lord
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2018-04       Impact factor: 2.441

9.  Circumventing embryonic lethality with Lcmt1 deficiency: generation of hypomorphic Lcmt1 mice with reduced protein phosphatase 2A methyltransferase expression and defects in insulin signaling.

Authors:  Kennen B MacKay; Yiping Tu; Stephen G Young; Steven G Clarke
Journal:  PLoS One       Date:  2013-06-20       Impact factor: 3.240

10.  Phosphotyrosine recognition domains: the typical, the atypical and the versatile.

Authors:  Tomonori Kaneko; Rakesh Joshi; Stephan M Feller; Shawn Sc Li
Journal:  Cell Commun Signal       Date:  2012-11-07       Impact factor: 5.712
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