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Literature DB >> 22583079

Cytotoxic metabolites from the antarctic psychrophilic fungus Oidiodendron truncatum.

Liyuan Li¹, Dehai Li, Yepeng Luan, Qianqun Gu, Tianjiao Zhu.

Abstract

Two new epipolythiodioxopiperazines, named chetracins B and C (1 and 2), and five new diketopiperazines, named chetracin D (4) and oidioperazines A-D (5, 10, 12, and 13), were isolated from the fungus Oidiodendron truncatum GW3-13, along with six known compounds (3, 6, 7, 8, 9, and 11). Their structures were elucidated by extensive NMR, MS, and CD analyses, as well as chemical transformation. An in vitro MTT cytotoxicity assay revealed potent biological activity for 1 in the nanomolar range against a panel of five human cancer lines.

Entities: Chemical Disease Species

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Year: 2012 PMID： 22583079 DOI： 10.1021/np3000443

Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050

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Cited

24 in total

1. Richness and bioactivity of culturable soil fungi from the Fildes Peninsula, Antarctica.

Authors: Zhuang Ding; Liyuan Li; Qian Che; Dehai Li; Qianqun Gu; Tianjiao Zhu
Journal: Extremophiles Date: 2016-05-03 Impact factor: 2.395

2. Enantioselective total syntheses of plectosphaeroic acids B and C.

Authors: Salman Y Jabri; Larry E Overman
Journal: J Org Chem Date: 2013-08-27 Impact factor: 4.354

Review 3. Epidithiodioxopiperazines. occurrence, synthesis and biogenesis.

Authors: Timothy R Welch; Robert M Williams
Journal: Nat Prod Rep Date: 2014-10 Impact factor: 13.423

4. Enantioselective total synthesis of plectosphaeroic acid B.

Authors: Salman Y Jabri; Larry E Overman
Journal: J Am Chem Soc Date: 2013-03-06 Impact factor: 15.419

5. General approach for preparing epidithiodioxopiperazines from trioxopiperazine precursors: enantioselective total syntheses of (+)- and (-)-gliocladine C, (+)-leptosin D, (+)-T988C, (+)-bionectin A, and (+)-gliocladin A.

Authors: John E DeLorbe; David Horne; Richard Jove; Steven M Mennen; Sangkil Nam; Fang-Li Zhang; Larry E Overman
Journal: J Am Chem Soc Date: 2013-03-01 Impact factor: 15.419

Cytotoxic metabolites from the antarctic psychrophilic fungus Oidiodendron truncatum.

1. Richness and bioactivity of culturable soil fungi from the Fildes Peninsula, Antarctica.

2. Enantioselective total syntheses of plectosphaeroic acids B and C.

Review 3. Epidithiodioxopiperazines. occurrence, synthesis and biogenesis.

4. Enantioselective total synthesis of plectosphaeroic acid B.

5. General approach for preparing epidithiodioxopiperazines from trioxopiperazine precursors: enantioselective total syntheses of (+)- and (-)-gliocladine C, (+)-leptosin D, (+)-T988C, (+)-bionectin A, and (+)-gliocladin A.

6. Versicones E-H and arugosin K produced by the mangrove-derived fungus Aspergillus versicolor HDN11-84.

7. Synthesis and Anticancer Activity of Epipolythiodiketopiperazine Alkaloids.

8. Identification of epipolythiodioxopiperazines HDN-1 and chaetocin as novel inhibitor of heat shock protein 90.

9. Indole diketopiperazines from endophytic Chaetomium sp 88194 induce breast cancer cell apoptotic death.

10. Westerdykella reniformis sp. nov., producing the antibiotic metabolites melinacidin IV and chetracin B.