PURPOSE: This study evaluated the feasibility of magnetic resonance (MR) volumetry using a diffusion-weighted data set (V(DWI)) and compared it with conventional T2-weighted volumetry (V(C)) in patients affected by rectal cancer treated with chemoradiation therapy (CHRT). MATERIALS AND METHODS: Fourteen patients with a biopsy diagnosis of rectal cancer underwent MR examination before and after CHRT. T2-weighted images were used to extrapolate V(C). A diffusion-weighted (DW) sequence was acquired [spin-echo diffusion-weighted echo-planar imaging (SE-DW-EPI)] with a b-value of 800 s/mm(2) and volume (V(DWI)) was calculated by semiautomatic segmentation of tumour hyperintensity. Two radiologists independently assessed volumes and analysed data in order to establish interobserver agreement and compare and correlate volumes to tumour regression grade (TRG), as evaluable at pathological examination of the surgical specimen. RESULTS: Interobserver agreement was 0.977 [(95% confidence interval (CI) 0.954-0.989) and 0.956 (95% CI 0.905-0.980) for V(C) and V(DWI) and 0.964 (95% CI 0.896-0.988) and 0.271 (95% CI-0.267 to 0.686) between V(C) and V(DWI) before and after CHRT. The correlation between TRG and V(C) and V(DWI) was, respectively, rho = 0.597 (p<0.05) and r(2)=0.156 (p=0.162) and rho=0.847 (p<0.001). CONCLUSIONS: V(DWI) seems to be a promising tool for assessing response to CHRT in rectal cancer. Further studies on large series of patients are needed to refine the technique and evaluate its potential predictive value.
PURPOSE: This study evaluated the feasibility of magnetic resonance (MR) volumetry using a diffusion-weighted data set (V(DWI)) and compared it with conventional T2-weighted volumetry (V(C)) in patients affected by rectal cancer treated with chemoradiation therapy (CHRT). MATERIALS AND METHODS: Fourteen patients with a biopsy diagnosis of rectal cancer underwent MR examination before and after CHRT. T2-weighted images were used to extrapolate V(C). A diffusion-weighted (DW) sequence was acquired [spin-echo diffusion-weighted echo-planar imaging (SE-DW-EPI)] with a b-value of 800 s/mm(2) and volume (V(DWI)) was calculated by semiautomatic segmentation of tumour hyperintensity. Two radiologists independently assessed volumes and analysed data in order to establish interobserver agreement and compare and correlate volumes to tumour regression grade (TRG), as evaluable at pathological examination of the surgical specimen. RESULTS: Interobserver agreement was 0.977 [(95% confidence interval (CI) 0.954-0.989) and 0.956 (95% CI 0.905-0.980) for V(C) and V(DWI) and 0.964 (95% CI 0.896-0.988) and 0.271 (95% CI-0.267 to 0.686) between V(C) and V(DWI) before and after CHRT. The correlation between TRG and V(C) and V(DWI) was, respectively, rho = 0.597 (p<0.05) and r(2)=0.156 (p=0.162) and rho=0.847 (p<0.001). CONCLUSIONS: V(DWI) seems to be a promising tool for assessing response to CHRT in rectal cancer. Further studies on large series of patients are needed to refine the technique and evaluate its potential predictive value.
Authors: T Denecke; B Rau; K-T Hoffmann; B Hildebrandt; J Ruf; M Gutberlet; M Hünerbein; R Felix; P Wust; H Amthauer Journal: Eur Radiol Date: 2005-04-02 Impact factor: 5.315
Authors: Fabio Maria Vecchio; Vincenzo Valentini; Bruce D Minsky; Gilbert D A Padula; Ennapadam S Venkatraman; Mario Balducci; Francesco Miccichè; Riccardo Ricci; Alessio Giuseppe Morganti; Maria Antonietta Gambacorta; Francesca Maurizi; Claudio Coco Journal: Int J Radiat Oncol Biol Phys Date: 2005-07-01 Impact factor: 7.038
Authors: N A Mayr; V A Magnotta; J C Ehrhardt; J A Wheeler; J I Sorosky; B C Wen; C S Davis; R E Pelsang; B Anderson; J F Doornbos; D H Hussey; W T Yuh Journal: Int J Radiat Oncol Biol Phys Date: 1996-07-15 Impact factor: 7.038
Authors: Giacomo Luccichenti; Filippo Cademartiri; Mario Sianesi; Luigi Roncoroni; Paolo Pavone; Gabriel P Krestin Journal: AJR Am J Roentgenol Date: 2005-02 Impact factor: 3.959
Authors: Michael R Torkzad; Johan Lindholm; Anna Martling; Björn Cedermark; Bengt Glimelius; Lennart Blomqvist Journal: Eur Radiol Date: 2007-01-31 Impact factor: 5.315
Authors: Jeong Hyun Kang; Young Chul Kim; Hyunki Kim; Young Wan Kim; Hyuk Hur; Jin Soo Kim; Byung Soh Min; Hogeun Kim; Joon Seok Lim; Jinsil Seong; Ki Chang Keum; Nam Kyu Kim Journal: Int J Radiat Oncol Biol Phys Date: 2009-08-03 Impact factor: 7.038
Authors: Pietro Valerio Foti; Giuseppe Privitera; Sebastiano Piana; Stefano Palmucci; Corrado Spatola; Roberta Bevilacqua; Luigi Raffaele; Vincenzo Salamone; Rosario Caltabiano; Gaetano Magro; Giovanni Li Destri; Pietro Milone; Giovanni Carlo Ettorre Journal: Eur J Radiol Open Date: 2016-07-18
Authors: Stefano Trebeschi; Joost J M van Griethuysen; Doenja M J Lambregts; Max J Lahaye; Chintan Parmar; Frans C H Bakers; Nicky H G M Peters; Regina G H Beets-Tan; Hugo J W L Aerts Journal: Sci Rep Date: 2017-07-13 Impact factor: 4.379
Authors: Mario Petrillo; Roberta Fusco; Orlando Catalano; Mario Sansone; Antonio Avallone; Paolo Delrio; Biagio Pecori; Fabiana Tatangelo; Antonella Petrillo Journal: Biomed Res Int Date: 2015-08-27 Impact factor: 3.411
Authors: Georgios C Manikis; Kostas Marias; Doenja M J Lambregts; Katerina Nikiforaki; Miriam M van Heeswijk; Frans C H Bakers; Regina G H Beets-Tan; Nikolaos Papanikolaou Journal: PLoS One Date: 2017-09-01 Impact factor: 3.240