BACKGROUND: Long-term results of both surgery and observation for patients with focal nodular hyperplasia (FNH) in a large single-center experience do not exist. Accordingly, the aim of this study was to compare long-term outcomes in patients with FNH who underwent either elective hepatectomy or observation alone. METHODS: A retrospective single-institution analysis of 185 patients with FNH, treated from 1990 to 2009, was performed. RESULTS: Seventy-eight patients underwent elective hepatectomy and 107 patients observation alone, with a median follow-up period of 113 months. There was no perioperative mortality. Postoperative complications were recorded in 12 patients, and 92% of patients reported symptomatic reductions. Among observation patients, 9 (13%) developed additional symptoms; tumor enlargement was seen in 3 patients (4%). CONCLUSIONS: Elective liver resection for FNH is a safe procedure at high-volume centers. This single-center experience showed that 13% of observed patients had protracted symptoms. This justifies the therapeutic algorithm that elective surgery should be considered in symptomatic patients or in those with marked enlargement.
BACKGROUND: Long-term results of both surgery and observation for patients with focal nodular hyperplasia (FNH) in a large single-center experience do not exist. Accordingly, the aim of this study was to compare long-term outcomes in patients with FNH who underwent either elective hepatectomy or observation alone. METHODS: A retrospective single-institution analysis of 185 patients with FNH, treated from 1990 to 2009, was performed. RESULTS: Seventy-eight patients underwent elective hepatectomy and 107 patients observation alone, with a median follow-up period of 113 months. There was no perioperative mortality. Postoperative complications were recorded in 12 patients, and 92% of patients reported symptomatic reductions. Among observation patients, 9 (13%) developed additional symptoms; tumor enlargement was seen in 3 patients (4%). CONCLUSIONS: Elective liver resection for FNH is a safe procedure at high-volume centers. This single-center experience showed that 13% of observed patients had protracted symptoms. This justifies the therapeutic algorithm that elective surgery should be considered in symptomatic patients or in those with marked enlargement.
Authors: Manju D Chandrasegaram; Ali Shah; John W Chen; Andrew Ruszkiewicz; David S Astill; Georgina England; Ravish S Raju; Eu Ling Neo; Paul M Dolan; Chuan Ping Tan; Mark Brooke-Smith; Tom Wilson; Robert T A Padbury; Christopher S Worthley Journal: HPB (Oxford) Date: 2015-02-28 Impact factor: 3.647
Authors: Mirelle E E Bröker; Anne J Klompenhouwer; Marcia P Gaspersz; Annick M E Alleleyn; Roy S Dwarkasing; Indra C Pieters; Robert A de Man; Jan N M IJzermans Journal: World J Surg Date: 2018-05 Impact factor: 3.352
Authors: Ashraf A Ashhab; Ahmad Abu-Sulb; Ju Dong Yang; Mazen Noureddin; Vinay Sundaram; Alexander Kuo; Walid S Ayoub Journal: ACG Case Rep J Date: 2021-01-13
Authors: Hans Michael Hau; Georgi Atanasov; Hans-Michael Tautenhahn; Rudolf Ascherl; Georg Wiltberger; Markus Bo Schoenberg; Mehmet Haluk Morgül; Dirk Uhlmann; Michael Moche; Jochen Fuchs; Moritz Schmelzle; Michael Bartels Journal: Eur J Med Res Date: 2015-10-22 Impact factor: 2.175