| Literature DB >> 22578324 |
Carolyn B Mervis1, Joana Dida, Emily Lam, Nicole A Crawford-Zelli, Edwin J Young, Danielle R Henderson, Tuncer Onay, Colleen A Morris, Janet Woodruff-Borden, John Yeomans, Lucy R Osborne.
Abstract
Duplication (dup7q11.23) and deletion (Williams syndrome) of chromosomal region 7q11.23 cause neurodevelopmental disorders with contrasting anxiety phenotypes. We found that 30% of 4- to 12-year-olds with dup7q11.23 but fewer than 5% of children with WS or in the general population met diagnostic criteria for a separation-anxiety disorder. To address the role of one commonly duplicated or deleted gene in separation anxiety, we compared mice that had varying numbers of Gtf2i copies. Relative to mouse pups with one or two Gtf2i copies, pups with additional Gtf2i copies showed significantly increased maternal separation-induced anxiety as measured by ultrasonic vocalizations. This study links the copy number of a single gene from 7q11.23 to separation anxiety in both mice and humans, highlighting the utility of mouse models in dissecting specific gene functions for genomic disorders that span many genes. This study also offers insight into molecular separation-anxiety pathways that might enable the development of targeted therapeutics.Entities:
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Year: 2012 PMID： 22578324 PMCID： PMC3370270 DOI： 10.1016/j.ajhg.2012.04.012
Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025