Literature DB >> 22577845

Retinoids: novel immunomodulators and tumour-suppressive agents?

M R Carratù1, C Marasco, G Mangialardi, A Vacca.   

Abstract

Retinoids play important roles in the transcriptional activity of normal, degenerative and tumour cells. Retinoid analogues may be promising therapeutic agents for the treatment of immune disorders as different as type I diabetes and systemic lupus erythematosus. In addition, the use of retinoids in cancer treatment has progressed significantly in the last two decades; thus, numerous retinoid compounds have been synthesized and tested. In this paper, the actual or potential use of retinoids as immunomodulators or tumour-suppressive agents is discussed.
© 2012 The Authors. British Journal of Pharmacology © 2012 The British Pharmacological Society.

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Year:  2012        PMID： 22577845      PMCID： PMC3449254          DOI： 10.1111/j.1476-5381.2012.02031.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  138 in total

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