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Literature DB >> 22575649

The crystal structure of the MPN domain from the COP9 signalosome subunit CSN6.

Heng Zhang¹, Zeng-Qiang Gao, Wen-Jia Wang, Guang-Feng Liu, Eleonora V Shtykova, Jian-Hua Xu, Lan-Fen Li, Xiao-Dong Su, Yu-Hui Dong.

Abstract

The COP9 signalosome (CSN) is a multiprotein complex containing eight subunits and is highly conserved from fungi to human. CSN is proposed to widely participate in many physiological processes, including protein degradation, DNA damage response and signal transduction. Among those subunits, only CSN5 and CSN6 belong to JAMM family. CSN5 possesses isopeptidase activity, but CSN6 lacks this ability. Here we report the 2.5Å crystal structure of MPN domain from Drosophila melanogaster CSN6. Structural comparison with other MPN domains, along with bioinformation analysis, suggests that MPN domain from CSN6 may serve as a scaffold instead of a metalloprotease.

Entities: Gene Species

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Year: 2012 PMID： 22575649 DOI： 10.1016/j.febslet.2012.03.029

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

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Cited

13 in total

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2. Crystal structure of the human COP9 signalosome.

Authors: Gondichatnahalli M Lingaraju; Richard D Bunker; Simone Cavadini; Daniel Hess; Ulrich Hassiepen; Martin Renatus; Eric S Fischer; Nicolas H Thomä
Journal: Nature Date: 2014-07-16 Impact factor: 49.962

3. Insights into the regulation of the human COP9 signalosome catalytic subunit, CSN5/Jab1.

Authors: Aude Echalier; Yunbao Pan; Melissa Birol; Nicolas Tavernier; Lionel Pintard; François Hoh; Christine Ebel; Nathalie Galophe; François X Claret; Christian Dumas
Journal: Proc Natl Acad Sci U S A Date: 2013-01-03 Impact factor: 11.205

4. Structure of the type VI effector-immunity complex (Tae4-Tai4) provides novel insights into the inhibition mechanism of the effector by its immunity protein.

Authors: Heng Zhang; Heng Zhang; Zeng-Qiang Gao; Wen-Jia Wang; Guang-Feng Liu; Jian-Hua Xu; Xiao-Dong Su; Yu-Hui Dong
Journal: J Biol Chem Date: 2013-01-03 Impact factor: 5.157

The crystal structure of the MPN domain from the COP9 signalosome subunit CSN6.

1. The COP9 signalosome: its regulation of cullin-based E3 ubiquitin ligases and role in photomorphogenesis.

2. Crystal structure of the human COP9 signalosome.

3. Insights into the regulation of the human COP9 signalosome catalytic subunit, CSN5/Jab1.

4. Structure of the type VI effector-immunity complex (Tae4-Tai4) provides novel insights into the inhibition mechanism of the effector by its immunity protein.

5. Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11.

6. Crystal structure and versatile functional roles of the COP9 signalosome subunit 1.

7. ERK2-Dependent Phosphorylation of CSN6 Is Critical in Colorectal Cancer Development.

8. Architecture of human translation initiation factor 3.

9. The minimal deneddylase core of the COP9 signalosome excludes the Csn6 MPN- domain.

Review 10. Signaling in the phytomicrobiome: breadth and potential.