BACKGROUND: Type 2 diabetes mellitus and hypertension are closely associated and contribute together to microvascular and macrovascular end-organ damage. Prevalence of hypertension is increased even in the prediabetic state. However, there is little information available about the relationship between incidence of hypertension and a deterioration of glucose tolerance from impaired glucose tolerance (IGT) to diabetes. METHODS: To clarify these issues we analysed data from the Stop non insulin dependent diabetes mellitus (STOP-NIDDM) trial - a prospective interventional study for the prevention of type 2 diabetes in people with prediabetes using thealpha-glucosidase inhibitor acarbose. Hypertension was already present at study entry in 702 (51.3%) of 1368 patients who were eligible for intention-to-treat analysis. RESULTS: A total of 96 out of the 666 normotensive individuals at baseline developed hypertension during the 3.3-year follow-up. The strongest risk factors for time to development of hypertension were abdominal obesity at baseline [hazard ratio 1.91, 95% confidence interval (CI) 1.19-3.05, P < 0.01] and worsening of glucose tolerance (hazard ratio 1.54, 95% CI 1.02-2.32, P < 0.05), whereas acarbose treatment reduced the risk of hypertension (hazard ratio 0.59, 95% CI 0.39-0.90, P < 0.05). CONCLUSION: A significant relationship was found between the development of type 2 diabetes and hypertension in patients with IGT, and treatment with acarbose, which primarily improved postprandial hyperglycaemia, reduced the incidence of hypertension as well as diabetes. This suggests that the two entities shared 'common soil'.
RCT Entities:
BACKGROUND:Type 2 diabetes mellitus and hypertension are closely associated and contribute together to microvascular and macrovascular end-organ damage. Prevalence of hypertension is increased even in the prediabetic state. However, there is little information available about the relationship between incidence of hypertension and a deterioration of glucose tolerance from impaired glucose tolerance (IGT) to diabetes. METHODS: To clarify these issues we analysed data from the Stop non insulin dependent diabetes mellitus (STOP-NIDDM) trial - a prospective interventional study for the prevention of type 2 diabetes in people with prediabetes using the alpha-glucosidase inhibitor acarbose. Hypertension was already present at study entry in 702 (51.3%) of 1368 patients who were eligible for intention-to-treat analysis. RESULTS: A total of 96 out of the 666 normotensive individuals at baseline developed hypertension during the 3.3-year follow-up. The strongest risk factors for time to development of hypertension were abdominal obesity at baseline [hazard ratio 1.91, 95% confidence interval (CI) 1.19-3.05, P < 0.01] and worsening of glucose tolerance (hazard ratio 1.54, 95% CI 1.02-2.32, P < 0.05), whereas acarbose treatment reduced the risk of hypertension (hazard ratio 0.59, 95% CI 0.39-0.90, P < 0.05). CONCLUSION: A significant relationship was found between the development of type 2 diabetes and hypertension in patients with IGT, and treatment with acarbose, which primarily improved postprandial hyperglycaemia, reduced the incidence of hypertension as well as diabetes. This suggests that the two entities shared 'common soil'.
Authors: Arash Mirrahimi; Laura Chiavaroli; Korbua Srichaikul; Livia S A Augustin; John L Sievenpiper; Cyril W C Kendall; David J A Jenkins Journal: Curr Atheroscler Rep Date: 2014-01 Impact factor: 5.113
Authors: Amy R Johnson; Yuanyuan Qin; Alyssa J Cozzo; Alex J Freemerman; Megan J Huang; Liyang Zhao; Brante P Sampey; J Justin Milner; Melinda A Beck; Blossom Damania; Naim Rashid; Joseph A Galanko; Douglas P Lee; Matthew L Edin; Darryl C Zeldin; Patrick T Fueger; Brittney Dietz; Andreas Stahl; Ying Wu; Karen L Mohlke; Liza Makowski Journal: Mol Metab Date: 2016-04-23 Impact factor: 7.422
Authors: Eberhard Standl; Michael J Theodorakis; Michael Erbach; Oliver Schnell; Jaakko Tuomilehto Journal: Cardiovasc Diabetol Date: 2014-04-16 Impact factor: 9.951
Authors: Markolf Hanefeld; Frank Pistrosch; Stefan R Bornstein; Andreas L Birkenfeld Journal: Rev Endocr Metab Disord Date: 2016-03 Impact factor: 6.514