OBJECTIVE: To evaluate the predictive value of random serum anti-Müllerian hormone (AMH) in the assessment of ovarian response in patients with diminished ovarian reserve (DOR; diagnosed after the observation of elevated baseline levels of early follicular follicle-stimulating hormone [FSH]) who were undergoing intracytoplasmic sperm injection-embryo transfer (ICSI-ET) and to compare the random serum AMH and baseline FSH levels in these patients for the prediction of poor ovarian response. DESIGN: Retrospective study. SETTING: University hospital. PATIENTS: One hundred and thirty-nine patients who were undergoing ICSI-ET cycles with early follicular FSH level >9 IU/mL. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Poor ovarian response in ICSI-ET cycles. RESULTS: For the identification of women at risk of cycle cancellation, an AMH cut-off level ≤1.2 ng/mL had 97.3 % sensitivity, 31.3 % specificity, 33.9 % positive predictive value, and 96.9 % negative predictive value in the women with high baseline FSH levels. An AMH cut-off level ≥1 ng/mL had a sensitivity of 58.7 % and specificity of 95.1 % for prediction of retrieval of 4 or more oocytes. By using a serum AMH cutoff level of 1.5 ng/mL, the ongoing pregnancies were predicted with 83.3 % sensitivity and 82.5 % specificity and yielded a positive predictive value of 31.2 % and a negative predictive value 98.1 %. CONCLUSION: Measurement of random serum AMH level is a useful tool in the prediction of ovarian response in patients with high serum early follicular FSH levels.
OBJECTIVE: To evaluate the predictive value of random serum anti-Müllerian hormone (AMH) in the assessment of ovarian response in patients with diminished ovarian reserve (DOR; diagnosed after the observation of elevated baseline levels of early follicular follicle-stimulating hormone [FSH]) who were undergoing intracytoplasmic sperm injection-embryo transfer (ICSI-ET) and to compare the random serum AMH and baseline FSH levels in these patients for the prediction of poor ovarian response. DESIGN: Retrospective study. SETTING: University hospital. PATIENTS: One hundred and thirty-nine patients who were undergoing ICSI-ET cycles with early follicular FSH level >9 IU/mL. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Poor ovarian response in ICSI-ET cycles. RESULTS: For the identification of women at risk of cycle cancellation, an AMH cut-off level ≤1.2 ng/mL had 97.3 % sensitivity, 31.3 % specificity, 33.9 % positive predictive value, and 96.9 % negative predictive value in the women with high baseline FSH levels. An AMH cut-off level ≥1 ng/mL had a sensitivity of 58.7 % and specificity of 95.1 % for prediction of retrieval of 4 or more oocytes. By using a serum AMH cutoff level of 1.5 ng/mL, the ongoing pregnancies were predicted with 83.3 % sensitivity and 82.5 % specificity and yielded a positive predictive value of 31.2 % and a negative predictive value 98.1 %. CONCLUSION: Measurement of random serum AMH level is a useful tool in the prediction of ovarian response in patients with high serum early follicular FSH levels.
Authors: László F J M M Bancsi; Frank J M Broekmans; Marinus J C Eijkemans; Frank H de Jong; J Dik F Habbema; Egbert R te Velde Journal: Fertil Steril Date: 2002-02 Impact factor: 7.329
Authors: Maria J G Gruijters; Jenny A Visser; Alexandra L L Durlinger; Axel P N Themmen Journal: Mol Cell Endocrinol Date: 2003-12-15 Impact factor: 4.102
Authors: M M Lee; P K Donahoe; T Hasegawa; B Silverman; G B Crist; S Best; Y Hasegawa; R A Noto; D Schoenfeld; D T MacLaughlin Journal: J Clin Endocrinol Metab Date: 1996-02 Impact factor: 5.958
Authors: Carolina P Rezende; Ana L Rocha; Cynthia Dela Cruz; Lavinia E Borges; Helen L Del Puerto; Fernando M Reis Journal: J Assist Reprod Genet Date: 2014-07-12 Impact factor: 3.412