Literature DB >> 22572827

Portrait of an immunoregulatory Bifidobacterium.

Patrycja Konieczna1, Cezmi A Akdis, Eamonn M M Quigley, Fergus Shanahan, Liam O'Mahony.   

Abstract

There is increasing interest in the administration of microbes or microbial metabolites for the prevention and treatment of aberrant inflammatory activity. The protective effects associated with these microbes are mediated by multiple mechanisms involving epithelial cells, DCs and T cells, but most data are derived from animal models. In this addendum, we summarize our recent data, showing that oral consumption of Bifidobacterium infantis 35624 is associated with enhanced IL-10 secretion and Foxp3 expression in human peripheral blood. In addition, we discuss the potential DC subset-specific mechanisms, which could contribute to DC(REG) and T(REG) programming by specific gut microbes.

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Year:  2012        PMID: 22572827      PMCID: PMC3427218          DOI: 10.4161/gmic.20358

Source DB:  PubMed          Journal:  Gut Microbes        ISSN: 1949-0976


  36 in total

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Review 4.  Natural regulatory T cells in infectious disease.

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5.  Differential cytokine response from dendritic cells to commensal and pathogenic bacteria in different lymphoid compartments in humans.

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7.  Lactobacillus and bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles.

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8.  Hypothalamic-pituitary-gut axis dysregulation in irritable bowel syndrome: plasma cytokines as a potential biomarker?

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  31 in total

Review 1.  The microbiome: stress, health and disease.

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2.  The Surface-Associated Exopolysaccharide of Bifidobacterium longum 35624 Plays an Essential Role in Dampening Host Proinflammatory Responses and Repressing Local TH17 Responses.

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3.  Gut bacteria in health and disease.

Authors:  Eamonn M M Quigley
Journal:  Gastroenterol Hepatol (N Y)       Date:  2013-09

Review 4.  Nutraceuticals as modulators of gut microbiota: Role in therapy.

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Review 5.  Current Perspectives on Antihypertensive Probiotics.

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6.  Probiotic Bifidobacterium breve MCC1274 Mitigates Alzheimer's Disease-Related Pathologies in Wild-Type Mice.

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Review 7.  Bugs on the brain; brain in the gut--seeking explanations for common gastrointestinal symptoms.

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8.  In Vivo Investigation of Supportive Immunotherapeutic Combination of Bifidobacterium infantis 35624 and Doxorubicin in Murine Breast Cancer.

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Review 9.  Engineered antigen-specific regulatory T cells for autoimmune skin conditions.

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10.  Immunomodulation by Bifidobacterium infantis 35624 in the murine lamina propria requires retinoic acid-dependent and independent mechanisms.

Authors:  Patrycja Konieczna; Ruth Ferstl; Mario Ziegler; Remo Frei; Dirk Nehrbass; Roger P Lauener; Cezmi A Akdis; Liam O'Mahony
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