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Literature DB >> 15785761

Natural regulatory T cells in infectious disease.

Abstract

This review discusses the control exerted by natural CD4(+) CD25(+) regulatory T cells (natural T(reg) cells) during infectious processes. Natural T(reg) cells may limit the magnitude of effector responses, which may result in failure to adequately control infection. However, natural T(reg) cells also help limit collateral tissue damage caused by vigorous antimicrobial immune responses. We describe here various situations in which the balance between natural T(reg) cells and effector immune functions influences the outcome of infection and discuss how manipulating this equilibrium might be exploited therapeutically.

Entities: Disease Gene

Mesh：

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Year: 2005 PMID： 15785761 DOI： 10.1038/ni1181

Source DB: PubMed Journal: Nat Immunol ISSN： 1529-2908 Impact factor: 25.606

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Cited

360 in total

1. Blocking IL-21 signaling ameliorates xenogeneic GVHD induced by human lymphocytes.

Authors: Keli L Hippen; Christoph Bucher; Dawn K Schirm; Amanda M Bearl; Ty Brender; Kathy A Mink; Kimberly S Waggie; Regis Peffault de Latour; Anne Janin; Julie M Curtsinger; Stacey R Dillon; Jeffrey S Miller; Gerard Socie; Bruce R Blazar
Journal: Blood Date: 2011-11-10 Impact factor: 22.113

2. Placental malaria-associated suppression of parasite-specific immune response in neonates has no major impact on systemic CD4 T cell homeostasis.

Authors: Valérie Soulard; Martin Amadoudji Zin; Catherine Fitting; Samad Ibitokou; Mayke Oesterholt; Adrian J F Luty; René-Xavier Perrin; Achille Massougbodji; Philippe Deloron; Antonio Bandeira; Nadine Fievet
Journal: Infect Immun Date: 2011-04-25 Impact factor: 3.441

3. A combination of a transforming growth factor-beta antagonist and an inhibitor of cyclooxygenase is an effective treatment for murine pulmonary tuberculosis.

Authors: R Hernández-Pando; H Orozco-Esteves; H A Maldonado; D Aguilar-León; M M Vilchis-Landeros; D A Mata-Espinosa; V Mendoza; F López-Casillas
Journal: Clin Exp Immunol Date: 2006-05 Impact factor: 4.330

Natural regulatory T cells in infectious disease.

1. Blocking IL-21 signaling ameliorates xenogeneic GVHD induced by human lymphocytes.

2. Placental malaria-associated suppression of parasite-specific immune response in neonates has no major impact on systemic CD4 T cell homeostasis.

3. A combination of a transforming growth factor-beta antagonist and an inhibitor of cyclooxygenase is an effective treatment for murine pulmonary tuberculosis.

4. FoxP3: A Key Player in T Regulatory Biology.

Review 5. HIV-1 immunopathogenesis in humanized mouse models.

6. Circulating CD4+ CD25+ regulatory T cells correlate with chronic hepatitis B infection.

7. Diacylglycerol kinase ζ limits the generation of natural regulatory T cells.

8. Selective priming and expansion of antigen-specific Foxp3- CD4+ T cells during Listeria monocytogenes infection.

9. T regulatory cells distinguish two types of primary hypophysitis.

10. [Viral infections].