Literature DB >> 22572749

Serial T-SPOT.TB and quantiFERON-TB-Gold In-Tube assays to monitor response to antitubercular treatment in Italian children with active or latent tuberculosis infection.

Elena Chiappini1, Francesca Bonsignori, Giusi Mangone, Luisa Galli, Rachele Mazzantini, Sara Sollai, Chiara Azzari, Maurizio de Martino.   

Abstract

We performed a prospective study to investigate T-SPOT.TB and QuantiFERON-TB Gold In-Tube (QFT-G-IT) dynamics during antitubercular treatment in active tuberculosis (TB) or latent TB. Eighteen children with latent TB and 26 with TB were enrolled. At 6 months of follow-up reversion rate was 5.88% (95% CI:0-13.79) for QFT-G-IT; 9.09% (95% CI:0.59-17.58) for T-SPOT.TB (P=0.921) in TB cases. Significant decline in quantitative response was observed exclusively in TB cases. Our results suggest that serial IGRA have limited use in children receiving antitubercular treatment.

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Year:  2012        PMID： 22572749     DOI： 10.1097/INF.0b013e31825d0d67

Source DB:  PubMed          Journal:  Pediatr Infect Dis J        ISSN： 0891-3668            Impact factor:   2.129


  8 in total

Review 1.  Recommendations for the diagnosis of pediatric tuberculosis.

Authors:  E Chiappini; A Lo Vecchio; S Garazzino; G L Marseglia; F Bernardi; E Castagnola; P Tomà; D Cirillo; C Russo; C Gabiano; D Ciofi; G Losurdo; M Bocchino; E Tortoli; M Tadolini; A Villani; A Guarino; S Esposito
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2016-01       Impact factor: 3.267

2.  Bacillus Calmette-Guérin (BCG) Revaccination of Adults with Latent Mycobacterium tuberculosis Infection Induces Long-Lived BCG-Reactive NK Cell Responses.

Authors:  Mark Hatherill; Thomas J Scriba; Sara Suliman; Hennie Geldenhuys; John L Johnson; Jane E Hughes; Erica Smit; Melissa Murphy; Asma Toefy; Lesedi Lerumo; Christiaan Hopley; Bernadette Pienaar; Phalkun Chheng; Elisa Nemes; Daniel F Hoft; Willem A Hanekom; W Henry Boom
Journal:  J Immunol       Date:  2016-07-13       Impact factor: 5.422

3.  Effect of isoniazid therapy for latent TB infection on QuantiFERON-TB gold in-tube responses in adults with positive tuberculin skin test results in a high TB incidence area: a controlled study.

Authors:  John L Johnson; Hendrik Geldenhuys; Bonnie A Thiel; Asma Toefy; Sara Suliman; Bernadette Pienaar; Phalkun Chheng; Thomas Scriba; W Henry Boom; Willem Hanekom; Mark Hatherill
Journal:  Chest       Date:  2014-03-01       Impact factor: 9.410

Review 4.  Systematic review and meta-analysis on the utility of Interferon-gamma release assays for the diagnosis of Mycobacterium tuberculosis infection in children: a 2013 update.

Authors:  S Sollai; L Galli; M de Martino; E Chiappini
Journal:  BMC Infect Dis       Date:  2014-01-08       Impact factor: 3.090

5.  M. tuberculosis infection and antigen specific cytokine response in healthcare workers frequently exposed to tuberculosis.

Authors:  Paulin N Essone; Marielle Leboueny; Anicet Christel Maloupazoa Siawaya; Amel Kévin Alame-Emane; Oriane Cordelia Aboumegone Biyogo; Patrice Hemery Dapnet Tadatsin; Amandine Mveang Nzoghe; Dimitri Ulrich Essamazokou; Ofilia Mvoundza Ndjindji; Guy-Stéphane Padzys; Selidji Todagbe Agnandji; Howard Takiff; Brigitte Gicquel; Joel Fleury Djoba Siawaya
Journal:  Sci Rep       Date:  2019-06-03       Impact factor: 4.379

6.  Using TBAg/PHA Ratio for Monitoring TB Treatment: A Prospective Multicenter Study.

Authors:  Xiaochen Wang; Mingwu Li; Guobiao Liu; Xiaoying Wu; Rong Wan; Hongyan Hou; Shiji Wu; Ziyong Sun; Haobin Kuang; Feng Wang
Journal:  J Clin Med       Date:  2022-06-29       Impact factor: 4.964

7.  Expression of USP18 and IL2RA Is Increased in Individuals Receiving Latent Tuberculosis Treatment with Isoniazid.

Authors:  Eleane de Oyarzabal; Lourdes García-García; Claudia Rangel-Escareño; Leticia Ferreyra-Reyes; Lorena Orozco; María Teresa Herrera; Claudia Carranza; Eduardo Sada; Esmeralda Juárez; Alfredo Ponce-de-León; José Sifuentes-Osornio; Robert J Wilkinson; Martha Torres
Journal:  J Immunol Res       Date:  2019-12-06       Impact factor: 4.818

Review 8.  Diagnosis for Latent Tuberculosis Infection: New Alternatives.

Authors:  Claudia Carranza; Sigifredo Pedraza-Sanchez; Eleane de Oyarzabal-Mendez; Martha Torres
Journal:  Front Immunol       Date:  2020-09-10       Impact factor: 7.561
  8 in total

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