BACKGROUND/AIMS: Detailed information on the age- and sex-specific relationships between diabetes and Alzheimer's disease (AD) is scarce. This study aims to prospectively investigate the age- and sex-specific incidence density and relative hazards of AD in relation to diabetes. METHODS: A total of 615,529 diabetic patients and 614,871 age- and sex-matched random controls were linked to the claim data from 2000-2008 to identify the first occurrence of a primary or secondary diagnosis of AD. Incidence density was calculated under the Poisson assumption. We also assessed the age- and sex-specific risk of AD in relation to diabetes with the Cox proportional hazards regression model. RESULTS: Over nearly 9 years of follow-up, a total of 4,615 diabetic subjects developed AD, representing a cumulative incidence rate of 0.75% (n = 3,873; 0.63% in controls). The overall incidence densities of AD for diabetic men and women, respectively, were 0.82 and 1.15 per 1,000 person-years, which were higher than those for control men and women (0.63 and 0.89 per 1,000 person-years, respectively). Diabetic patients had a significantly higher hazard ratio (HR) of AD [1.45, 95% confidence interval (CI) 1.38-1.52]. Diabetic women ≥65 years had a higher HR (1.52, 95% CI 1.42-1.62) than diabetic women <65 years (1.34, 95% CI 1.15-1.56). CONCLUSION: Diabetes may increase the risk of AD in both sexes and in all ages. A higher HR of AD was especially notable in older diabetic women.
BACKGROUND/AIMS: Detailed information on the age- and sex-specific relationships between diabetes and Alzheimer's disease (AD) is scarce. This study aims to prospectively investigate the age- and sex-specific incidence density and relative hazards of AD in relation to diabetes. METHODS: A total of 615,529 diabeticpatients and 614,871 age- and sex-matched random controls were linked to the claim data from 2000-2008 to identify the first occurrence of a primary or secondary diagnosis of AD. Incidence density was calculated under the Poisson assumption. We also assessed the age- and sex-specific risk of AD in relation to diabetes with the Cox proportional hazards regression model. RESULTS: Over nearly 9 years of follow-up, a total of 4,615 diabetic subjects developed AD, representing a cumulative incidence rate of 0.75% (n = 3,873; 0.63% in controls). The overall incidence densities of AD for diabeticmen and women, respectively, were 0.82 and 1.15 per 1,000 person-years, which were higher than those for control men and women (0.63 and 0.89 per 1,000 person-years, respectively). Diabeticpatients had a significantly higher hazard ratio (HR) of AD [1.45, 95% confidence interval (CI) 1.38-1.52]. Diabeticwomen ≥65 years had a higher HR (1.52, 95% CI 1.42-1.62) than diabeticwomen <65 years (1.34, 95% CI 1.15-1.56). CONCLUSION:Diabetes may increase the risk of AD in both sexes and in all ages. A higher HR of AD was especially notable in older diabeticwomen.
Authors: Kai Long Zhong; Fang Chen; Hao Hong; Xuan Ke; Yang Ge Lv; Su Su Tang; Yu Bing Zhu Journal: Metab Brain Dis Date: 2018-04-06 Impact factor: 3.584
Authors: A Foubert-Samier; M Le Goff; C Helmer; K Pérès; J-M Orgogozo; P Barberger-Gateau; H Amieva; J-F Dartigues Journal: J Nutr Health Aging Date: 2014-12 Impact factor: 4.075
Authors: E Candeias; A I Duarte; I Sebastião; M A Fernandes; A I Plácido; C Carvalho; S Correia; R X Santos; R Seiça; M S Santos; C R Oliveira; P I Moreira Journal: Mol Neurobiol Date: 2016-10-11 Impact factor: 5.590
Authors: Dana M Niedowicz; Christa M Studzinski; Adam M Weidner; Thomas L Platt; Kristen N Kingry; Tina L Beckett; Annadora J Bruce-Keller; Jeffrey N Keller; M Paul Murphy Journal: Biochim Biophys Acta Date: 2012-12-26