OBJECTIVE: The purpose of this study is to clarify the median age at natural menopause and the proportions of women with premature ovarian failure (POF) and early menopause (EM) by using Kaplan-Meier cumulative estimates and differences in reproductive and lifestyle factors associated with POF, EM and median age at menopause in a large population of Japanese women. SUBJECTS AND METHODS: This study is a cross-sectional analysis of the Japan Nurses' Health Study (JNHS). We analyzed data for 24,152 pre- and postmenopausal women who were 40 years or older at the JNHS baseline survey. RESULTS: The overall estimated median age at natural menopause was 52.1 years, and the proportions of women with POF and EM were 0.28% and 1.67%, respectively. Older generation, cigarette smoking, low body mass index, regular menstruation cycles at 18-22 years of age, nulliparity and unilateral oophorectomy were associated with earlier onset of natural menopause. Only unilateral oophorectomy was associated with increased risk of POF, and nulliparity and unilateral oophorectomy were associated with increased risk of EM. CONCLUSION: Unilateral oophorectomy is a common factor associated with earlier onset of menopause, EM and POF, although other reproductive and lifestyle factors are not associated with POF or EM.
OBJECTIVE: The purpose of this study is to clarify the median age at natural menopause and the proportions of women with premature ovarian failure (POF) and early menopause (EM) by using Kaplan-Meier cumulative estimates and differences in reproductive and lifestyle factors associated with POF, EM and median age at menopause in a large population of Japanese women. SUBJECTS AND METHODS: This study is a cross-sectional analysis of the Japan Nurses' Health Study (JNHS). We analyzed data for 24,152 pre- and postmenopausal women who were 40 years or older at the JNHS baseline survey. RESULTS: The overall estimated median age at natural menopause was 52.1 years, and the proportions of women with POF and EM were 0.28% and 1.67%, respectively. Older generation, cigarette smoking, low body mass index, regular menstruation cycles at 18-22 years of age, nulliparity and unilateral oophorectomy were associated with earlier onset of natural menopause. Only unilateral oophorectomy was associated with increased risk of POF, and nulliparity and unilateral oophorectomy were associated with increased risk of EM. CONCLUSION: Unilateral oophorectomy is a common factor associated with earlier onset of menopause, EM and POF, although other reproductive and lifestyle factors are not associated with POF or EM.
Authors: Brian W Whitcomb; Alexandra Purdue-Smithe; Susan E Hankinson; JoAnn E Manson; Bernard A Rosner; Elizabeth R Bertone-Johnson Journal: J Clin Endocrinol Metab Date: 2018-10-01 Impact factor: 5.958
Authors: Erin E Rowell; Kristine S Corkum; Timothy B Lautz; Monica M Laronda; Amy L Walz; Mary Beth Madonna; Barbara A Lockart; Marleta Reynolds Journal: J Pediatr Surg Date: 2018-06-09 Impact factor: 2.545
Authors: Brian W Whitcomb; Alexandra C Purdue-Smithe; Kathleen L Szegda; Maegan E Boutot; Susan E Hankinson; JoAnn E Manson; Bernard Rosner; Walter C Willett; A Heather Eliassen; Elizabeth R Bertone-Johnson Journal: Am J Epidemiol Date: 2018-04-01 Impact factor: 4.897
Authors: Dongshan Zhu; Hsin-Fang Chung; Nirmala Pandeya; Annette J Dobson; Diana Kuh; Sybil L Crawford; Ellen B Gold; Nancy E Avis; Graham G Giles; Fiona Bruinsma; Hans-Olov Adami; Elisabete Weiderpass; Darren C Greenwood; Janet E Cade; Ellen S Mitchell; Nancy F Woods; Eric J Brunner; Mette Kildevæld Simonsen; Gita D Mishra Journal: Eur J Epidemiol Date: 2018-02-19 Impact factor: 8.082
Authors: J S Brand; N C Onland-Moret; M J C Eijkemans; A Tjønneland; N Roswall; K Overvad; G Fagherazzi; F Clavel-Chapelon; L Dossus; A Lukanova; V Grote; M M Bergmann; H Boeing; A Trichopoulou; M Tzivoglou; D Trichopoulos; S Grioni; A Mattiello; G Masala; R Tumino; P Vineis; H B Bueno-de-Mesquita; E Weiderpass; M L Redondo; M J Sánchez; J M Huerta Castaño; L Arriola; E Ardanaz; E J Duell; O Rolandsson; P W Franks; S Butt; P Nilsson; K T Khaw; N Wareham; R Travis; I Romieu; M J Gunter; E Riboli; Y T van der Schouw Journal: Hum Reprod Date: 2015-03-15 Impact factor: 6.918
Authors: Nydjie P Grimes; Brian W Whitcomb; Katherine W Reeves; Lynnette L Sievert; Alexandra Purdue-Smithe; JoAnn E Manson; Susan E Hankinson; Bernard A Rosner; Elizabeth R Bertone-Johnson Journal: Maturitas Date: 2021-09-20 Impact factor: 4.342