| Literature DB >> 22569231 |
Magali Gary-Bobo1, Youssef Mir, Cédric Rouxel, David Brevet, Ouahiba Hocine, Marie Maynadier, Audrey Gallud, Afitz Da Silva, Olivier Mongin, Mireille Blanchard-Desce, Sébastien Richeter, Bernard Loock, Philippe Maillard, Alain Morère, Marcel Garcia, Laurence Raehm, Jean-Olivier Durand.
Abstract
In this work, we focused on mesoporous silica nanoparticles (MSN) for one photon excitated photodynamic therapy (OPE-PDT) combined with drug delivery and carbohydrate targeting applied on retinoblastoma, a rare disease of childhood. We demonstrate that bitherapy (camptothecin delivery and photodynamic therapy) performed with MSN on retinoblastoma cancer cells was efficient in inducing cancer cell death. Alternatively MSN designed for two-photon excited photodynamic therapy (TPE-PDT) were also studied and irradiation at low fluence efficiently killed retinoblastoma cancer cells.Entities:
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Year: 2012 PMID： 22569231 DOI： 10.1016/j.ijpharm.2012.04.056
Source DB: PubMed Journal: Int J Pharm ISSN： 0378-5173 Impact factor: 5.875