| Literature DB >> 22569182 |
Aruni S Arachchige Don1, Chi Kwan Tsang, Tatiana M Kazdoba, Gabriella D'Arcangelo, Wise Young, X F Steven Zheng.
Abstract
The adult central nervous system (CNS) has a remarkable ability to repair itself. However, severe brain and spinal cord injuries (SCIs) cause lasting disability and there are only a few therapies that can prevent or restore function in such cases. In this review, we provide an overview of traumatic CNS injuries and discuss several emerging pharmacological options that have shown promise in preclinical and early clinical studies. We highlight therapies that modulate mammalian target of rapamycin (mTOR) signaling, a pathway that is well known for its roles in cell growth, metabolism and cancer. Interestingly, this pathway is also gaining newfound attention for its role in CNS repair and regeneration.Entities:
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Year: 2012 PMID： 22569182 PMCID： PMC3411916 DOI： 10.1016/j.drudis.2012.04.010
Source DB: PubMed Journal: Drug Discov Today ISSN： 1359-6446 Impact factor: 7.851