Literature DB >> 22564679

Complexity generation during natural product biosynthesis using redox enzymes.

Peng Wang1, Xue Gao, Yi Tang.   

Abstract

Redox enzymes such as FAD-dependent and cytochrome P450 oxygenases play indispensible roles in generating structural complexity during natural product biosynthesis. In the pre-assembly steps, redox enzymes can convert garden variety primary metabolites into unique starter and extender building blocks. In the post-assembly tailoring steps, redox cascades can transform nascent scaffolds into structurally complex final products. In this review, we will discuss several recently characterized redox enzymes in the biosynthesis of polyketides and nonribosomal peptides.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 22564679      PMCID： PMC3415589          DOI： 10.1016/j.cbpa.2012.04.008

Source DB:  PubMed          Journal:  Curr Opin Chem Biol        ISSN： 1367-5931            Impact factor:   8.822


  46 in total

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Journal:  Angew Chem Int Ed Engl       Date:  2002-12-02       Impact factor: 15.336

2.  Double oxidation of the cyclic nonaketide dihydromonacolin L to monacolin J by a single cytochrome P450 monooxygenase, LovA.

Authors:  Jorge Barriuso; Don T Nguyen; Jesse W-H Li; Joseph N Roberts; Gillian MacNevin; Jennifer L Chaytor; Sandra L Marcus; John C Vederas; Dae-Kyun Ro
Journal:  J Am Chem Soc       Date:  2011-04-15       Impact factor: 15.419

3.  A branched extender unit shared between two orthogonal polyketide pathways in an endophyte.

Authors:  Zhongli Xu; Ling Ding; Christian Hertweck
Journal:  Angew Chem Int Ed Engl       Date:  2011-04-19       Impact factor: 15.336

4.  Identification of phenylalanine 3-hydroxylase for meta-tyrosine biosynthesis.

Authors:  Wenjun Zhang; Brian D Ames; Christopher T Walsh
Journal:  Biochemistry       Date:  2011-05-31       Impact factor: 3.162

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Authors:  SangJoon Mo; Dong Hwan Kim; Jong Hyun Lee; Je Won Park; Devi B Basnet; Yeon Hee Ban; Young Ji Yoo; Shu-wei Chen; Sung Ryeol Park; Eun Ae Choi; Eunji Kim; Ying-Yu Jin; Sung-Kwon Lee; Ju Yeol Park; Yuan Liu; Mi Ok Lee; Keum Soon Lee; Sang Jun Kim; Dooil Kim; Byoung Chul Park; Sang-gi Lee; Ho Jeong Kwon; Joo-Won Suh; Bradley S Moore; Si-Kyu Lim; Yeo Joon Yoon
Journal:  J Am Chem Soc       Date:  2010-12-22       Impact factor: 15.419

6.  Cloning, sequencing and characterization of the biosynthetic gene cluster of sanglifehrin A, a potent cyclophilin inhibitor.

Authors:  Xudong Qu; Nan Jiang; Fei Xu; Lei Shao; Gongli Tang; Barrie Wilkinson; Wen Liu
Journal:  Mol Biosyst       Date:  2011-03

7.  Fungal indole alkaloid biosynthesis: genetic and biochemical investigation of the tryptoquialanine pathway in Penicillium aethiopicum.

Authors:  Xue Gao; Yit-Heng Chooi; Brian D Ames; Peng Wang; Christopher T Walsh; Yi Tang
Journal:  J Am Chem Soc       Date:  2011-02-07       Impact factor: 15.419

8.  Enzymatic processing of fumiquinazoline F: a tandem oxidative-acylation strategy for the generation of multicyclic scaffolds in fungal indole alkaloid biosynthesis.

Authors:  Brian D Ames; Xinyu Liu; Christopher T Walsh
Journal:  Biochemistry       Date:  2010-09-08       Impact factor: 3.162

9.  The nonribosomal peptide synthetase enzyme DdaD tethers N(β)-fumaramoyl-l-2,3-diaminopropionate for Fe(II)/α-ketoglutarate-dependent epoxidation by DdaC during dapdiamide antibiotic biosynthesis.

Authors:  Marie A Hollenhorst; Stefanie B Bumpus; Megan L Matthews; J Martin Bollinger; Neil L Kelleher; Christopher T Walsh
Journal:  J Am Chem Soc       Date:  2010-11-10       Impact factor: 15.419

10.  Production of the antimalarial drug precursor artemisinic acid in engineered yeast.

Authors:  Dae-Kyun Ro; Eric M Paradise; Mario Ouellet; Karl J Fisher; Karyn L Newman; John M Ndungu; Kimberly A Ho; Rachel A Eachus; Timothy S Ham; James Kirby; Michelle C Y Chang; Sydnor T Withers; Yoichiro Shiba; Richmond Sarpong; Jay D Keasling
Journal:  Nature       Date:  2006-04-13       Impact factor: 49.962
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  9 in total

1.  Distinct mechanisms for spiro-carbon formation reveal biosynthetic pathway crosstalk.

Authors:  Yuta Tsunematsu; Noriyasu Ishikawa; Daigo Wakana; Yukihiro Goda; Hiroshi Noguchi; Hisao Moriya; Kinya Hotta; Kenji Watanabe
Journal:  Nat Chem Biol       Date:  2013-10-13       Impact factor: 15.040

2.  Schultriene and nigtetraene: two sesterterpenes characterized from pathogenetic fungi via genome mining approach.

Authors:  Lan Jiang; Huanting Yang; Xue Zhang; Xiaoying Li; Kangjie Lv; Weiyan Zhang; Guoliang Zhu; Chengwei Liu; Yongheng Wang; Tom Hsiang; Lixin Zhang; Xueting Liu
Journal:  Appl Microbiol Biotechnol       Date:  2022-08-30       Impact factor: 5.560

3.  Elucidation of pseurotin biosynthetic pathway points to trans-acting C-methyltransferase: generation of chemical diversity.

Authors:  Yuta Tsunematsu; Manami Fukutomi; Takayoshi Saruwatari; Hiroshi Noguchi; Kinya Hotta; Yi Tang; Kenji Watanabe
Journal:  Angew Chem Int Ed Engl       Date:  2014-06-18       Impact factor: 15.336

4.  Combinatorial Generation of Chemical Diversity by Redox Enzymes in Chaetoviridin Biosynthesis.

Authors:  Michio Sato; Jaclyn M Winter; Shinji Kishimoto; Hiroshi Noguchi; Yi Tang; Kenji Watanabe
Journal:  Org Lett       Date:  2016-03-09       Impact factor: 6.005

5.  New natural products isolated from Metarhizium robertsii ARSEF 23 by chemical screening and identification of the gene cluster through engineered biosynthesis in Aspergillus nidulans A1145.

Authors:  Hiroki Kato; Yuta Tsunematsu; Tsuyoshi Yamamoto; Takuya Namiki; Shinji Kishimoto; Hiroshi Noguchi; Kenji Watanabe
Journal:  J Antibiot (Tokyo)       Date:  2016-05-18       Impact factor: 2.649

6.  Acthi, a thiazole biosynthesis enzyme, is essential for thiamine biosynthesis and CPC production in Acremonium chrysogenum.

Authors:  Yan Liu; Wei Zhang; Liping Xie; Hong Liu; Guihua Gong; Baoquan Zhu; Youjia Hu
Journal:  Microb Cell Fact       Date:  2015-04-11       Impact factor: 5.328

7.  Oxidative diversification of amino acids and peptides by small-molecule iron catalysis.

Authors:  Thomas J Osberger; Donald C Rogness; Jeffrey T Kohrt; Antonia F Stepan; M Christina White
Journal:  Nature       Date:  2016-08-01       Impact factor: 49.962

Review 8.  A roadmap for metagenomic enzyme discovery.

Authors:  Serina L Robinson; Jörn Piel; Shinichi Sunagawa
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Review 9.  Properties and Mechanisms of Flavin-Dependent Monooxygenases and Their Applications in Natural Product Synthesis.

Authors:  Yaming Deng; Quan Zhou; Yuzhou Wu; Xi Chen; Fangrui Zhong
Journal:  Int J Mol Sci       Date:  2022-02-27       Impact factor: 5.923
  9 in total

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