BACKGROUND: The occurrence of celiac disease (CD) in patients with type 1 diabetes (T1D) is increasing. OBJECTIVE: To determine the effect of CD on growth and glycemic control in patients with T1D, and the effects of adherence to gluten-free diet (GFD) on these parameters. PATIENTS AND METHODS: A longitudinal retrospective case-control design was used. The medical files of 68 patients with T1D and duodenal-biopsy-confirmed CD were reviewed for data on weight, height, hemoglobin A1c (HbA1c), frequency of diabetic ketoacidosis (DKA), and severe hypoglycemic events before and after diagnosis and treatment of CD. Findings were compared with 131 patients with T1D only matched for age, gender, and duration of diabetes. RESULTS: CD was diagnosed in 5.5% of all patients with T1D attending our center during the study period; 26% of the patients with CD were symptomatic. There were no significant differences in glycemic control or frequency of severe hypoglycemia or DKA events between the study and control groups. Body mass index-standard deviation score (SDS), height-SDS, and HbA1c values were marginally but not significantly higher in the control than the study group and similar in subjects with CD with good or fair/poor adherence to a GFD throughout follow-up. CONCLUSIONS: Patients with T1D and CD treated with GFD have growth and measures of metabolic control similar to those with T1D without CD. The decision whether asymptomatic celiac patients should be put on a GFD or only symptomatic patients has to be weighed against possible short- and long-term consequences of no intervention, and should be based on more evidence from larger randomized studies.
BACKGROUND: The occurrence of celiac disease (CD) in patients with type 1 diabetes (T1D) is increasing. OBJECTIVE: To determine the effect of CD on growth and glycemic control in patients with T1D, and the effects of adherence to gluten-free diet (GFD) on these parameters. PATIENTS AND METHODS: A longitudinal retrospective case-control design was used. The medical files of 68 patients with T1D and duodenal-biopsy-confirmed CD were reviewed for data on weight, height, hemoglobin A1c (HbA1c), frequency of diabetic ketoacidosis (DKA), and severe hypoglycemic events before and after diagnosis and treatment of CD. Findings were compared with 131 patients with T1D only matched for age, gender, and duration of diabetes. RESULTS: CD was diagnosed in 5.5% of all patients with T1D attending our center during the study period; 26% of the patients with CD were symptomatic. There were no significant differences in glycemic control or frequency of severe hypoglycemia or DKA events between the study and control groups. Body mass index-standard deviation score (SDS), height-SDS, and HbA1c values were marginally but not significantly higher in the control than the study group and similar in subjects with CD with good or fair/poor adherence to a GFD throughout follow-up. CONCLUSIONS:Patients with T1D and CD treated with GFD have growth and measures of metabolic control similar to those with T1D without CD. The decision whether asymptomatic celiac patients should be put on a GFD or only symptomatic patients has to be weighed against possible short- and long-term consequences of no intervention, and should be based on more evidence from larger randomized studies.
Authors: Clemens Kamrath; Sascha R Tittel; Desiree Dunstheimer; Elke Fröhlich-Reiterer; Markus Freff; Claudia Böttcher; Nadine Scheffler; Stefanie Lenze; Elke Gericke; Susanne Thiele; Reinhard W Holl Journal: Diabetologia Date: 2022-04-30 Impact factor: 10.460
Authors: Farid H Mahmud; Emilia N De Melo; Karima Noordin; Esther Assor; Kamaljeet Sahota; Jolie Davies-Shaw; Ernest Cutz; Gino Somers; Margaret Lawson; David R Mack; Patricia Gallego; Charlotte McDonald; Melanie D Beaton; Kevin Bax; Fred Saibil; Jeremy Gilbert; Susan Kirsch; Bruce A Perkins; Maria Cino; Eva Szentgyorgyi; Dror Koltin; Amish Parikh; Geetha Mukerji; Andrew Advani; Olivia Lou; Margaret A Marcon Journal: BMJ Open Date: 2015-05-11 Impact factor: 2.692
Authors: Esther Assor; Margaret A Marcon; Natasha Hamilton; Marilyn Fry; Tammy Cooper; Farid H Mahmud Journal: BMC Gastroenterol Date: 2015-12-21 Impact factor: 3.067