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Literature DB >> 22563824

Is manganese (II) pentaazamacrocyclic superoxide dismutase mimic beneficial for human sperm mitochondria function and motility?

Vesna Otasevic¹, Aleksandra Korac, Milica Vucetic, Biljana Macanovic, Eliana Garalejic, Ivana Ivanovic-Burmazovic, Milos R Filipovic, Biljana Buzadzic, Ana Stancic, Aleksandra Jankovic, Ksenija Velickovic, Igor Golic, Milica Markelic, Bato Korac.

Abstract

Mitochondria play an important role in sperm cell maturation and function. Here, we examined whether (and how) changes in sperm redox milieu affect the functional status of sperm mitochondria, that is, sperm functionality. Compared with the control, incubation in Tyrode's medium for 3 h, under noncapacitating conditions, decreased sperm motility, the amount of nitric oxide ((•)NO), the number of MitoTracker(®) Green FM (MT-G) positive mitochondria, and the expression of complexes I and IV of the mitochondrial respiratory chain. In turn, superoxide dismutase (SOD) mimic (M40403) treatment restored/increased these parameters, as well as the expression of endothelial nitric oxide synthase, manganese SOD, and catalase. These data lead to the hypothesis that M40403 improves mitochondrial functional state and motility of spermatozoa, as well as (•)NO might be involved in the observed effects of the mimic.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 2012 PMID： 22563824 PMCID： PMC3513981 DOI： 10.1089/ars.2012.4684

Source DB: PubMed Journal: Antioxid Redox Signal ISSN： 1523-0864 Impact factor: 8.401

9 in total

Review 1. On the selectivity of superoxide dismutase mimetics and its importance in pharmacological studies.

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Journal: Br J Pharmacol Date: 2003-10 Impact factor: 8.739

2. Mitochondrial molecular basis of sevoflurane and propofol cardioprotection in patients undergoing aortic valve replacement with cardiopulmonary bypass.

Authors: Miomir Jovic; Ana Stancic; Dragan Nenadic; Olivera Cekic; Dusko Nezic; Predrag Milojevic; Slobodan Micovic; Biljana Buzadzic; Aleksandra Korac; Vesna Otasevic; Aleksandra Jankovic; Milica Vucetic; Ksenija Velickovic; Igor Golic; Bato Korac
Journal: Cell Physiol Biochem Date: 2012-03-01

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Journal: Science Date: 1999-10-08 Impact factor: 47.728

4. Does prohibitin expression regulate sperm mitochondrial membrane potential, sperm motility, and male fertility?

Authors: Mei-Jiao Wang; Jia-Xian Ou; Guo-Wu Chen; Jun-Ping Wu; Hui-Juan Shi; Wai-Sum O; Patricia A Martin-DeLeon; Hong Chen
Journal: Antioxid Redox Signal Date: 2012-03-20 Impact factor: 8.401

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Authors: R Stanislavov; V Nikolova; P Rohdewald
Journal: Phytother Res Date: 2009-03 Impact factor: 5.878

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7. Control of superoxide and nitric oxide formation during human sperm capacitation.

Authors: Eve de Lamirande; Geneviève Lamothe; Michèle Villemure
Journal: Free Radic Biol Med Date: 2009-03-04 Impact factor: 7.376

Review 8. Mitochondrial functionality in reproduction: from gonads and gametes to embryos and embryonic stem cells.

Authors: João Ramalho-Santos; Sandra Varum; Sandra Amaral; Paula C Mota; Ana Paula Sousa; Alexandra Amaral
Journal: Hum Reprod Update Date: 2009-05-04 Impact factor: 15.610

9. Not all sperm are equal: functional mitochondria characterize a subpopulation of human sperm with better fertilization potential.

Authors: Ana Paula Sousa; Alexandra Amaral; Marta Baptista; Renata Tavares; Pedro Caballero Campo; Pedro Caballero Peregrín; Albertina Freitas; Artur Paiva; Teresa Almeida-Santos; João Ramalho-Santos
Journal: PLoS One Date: 2011-03-23 Impact factor: 3.240

9 in total

5 in total

Review 1. New insights into male (in)fertility: the importance of NO.

Authors: B Buzadzic; M Vucetic; A Jankovic; A Stancic; A Korac; B Korac; V Otasevic
Journal: Br J Pharmacol Date: 2014-07-02 Impact factor: 8.739

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Journal: Redox Biol Date: 2017-05-18 Impact factor: 11.799