Literature DB >> 22561820

King of hearts: a splicing factor rules cardiac proteins.

Wolfgang A Linke1, Sandra Bücker.   

Abstract

Alternative splicing ensures the expression of functionally diverse proteins from individual genes; however, aberrant mRNA splicing is associated with various conditions, including heart disease. A recent study provides new mechanistic insights into heart failure by showing that a human cardiomyopathy-linked mutation in a cardiac splice factor affects post-transcriptional regulation, causing the expression of anomalous isoforms of a whole network of cardiac proteins (pages 766-773).

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Year:  2012        PMID： 22561820     DOI： 10.1038/nm.2762

Source DB:  PubMed          Journal:  Nat Med        ISSN： 1078-8956            Impact factor:   53.440


  13 in total

1.  Genetic variation in the alternative splicing regulator RBM20 is associated with dilated cardiomyopathy.

Authors:  Marwan M Refaat; Steven A Lubitz; Seiko Makino; Zahid Islam; J Michael Frangiskakis; Haider Mehdi; Rebecca Gutmann; Michael L Zhang; Heather L Bloom; Calum A MacRae; Samuel C Dudley; Alaa A Shalaby; Raul Weiss; Dennis M McNamara; Barry London; Patrick T Ellinor
Journal:  Heart Rhythm       Date:  2011-10-17       Impact factor: 6.343

2.  Genetic variation in titin in arrhythmogenic right ventricular cardiomyopathy-overlap syndromes.

Authors:  Matthew Taylor; Sharon Graw; Gianfranco Sinagra; Carl Barnes; Dobromir Slavov; Francesca Brun; Bruno Pinamonti; Ernesto E Salcedo; William Sauer; Stylianos Pyxaras; Brian Anderson; Bernd Simon; Julius Bogomolovas; Siegfried Labeit; Henk Granzier; Luisa Mestroni
Journal:  Circulation       Date:  2011-08-01       Impact factor: 29.690

3.  Splicing and dilated cardiomyopathy one gene to rule them all?

Authors:  Calum A Macrae; William J McKenna
Journal:  J Am Coll Cardiol       Date:  2009-09-01       Impact factor: 24.094

4.  ASF/SF2-regulated CaMKIIdelta alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle.

Authors:  Xiangdong Xu; Dongmei Yang; Jian-Hua Ding; Wang Wang; Pao-Hsien Chu; Nancy D Dalton; Huan-You Wang; John R Bermingham; Zhen Ye; Forrest Liu; Michael G Rosenfeld; James L Manley; John Ross; Ju Chen; Rui-Ping Xiao; Heping Cheng; Xiang-Dong Fu
Journal:  Cell       Date:  2005-01-14       Impact factor: 41.582

5.  RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing.

Authors:  Wei Guo; Sebastian Schafer; Marion L Greaser; Michael H Radke; Martin Liss; Thirupugal Govindarajan; Henrike Maatz; Herbert Schulz; Shijun Li; Amanda M Parrish; Vita Dauksaite; Padmanabhan Vakeel; Sabine Klaassen; Brenda Gerull; Ludwig Thierfelder; Vera Regitz-Zagrosek; Timothy A Hacker; Kurt W Saupe; G William Dec; Patrick T Ellinor; Calum A MacRae; Bastian Spallek; Robert Fischer; Andreas Perrot; Cemil Özcelik; Kathrin Saar; Norbert Hubner; Michael Gotthardt
Journal:  Nat Med       Date:  2012-05       Impact factor: 53.440

6.  Mutations in ribonucleic acid binding protein gene cause familial dilated cardiomyopathy.

Authors:  Katharine M Brauch; Margaret L Karst; Kathleen J Herron; Mariza de Andrade; Patricia A Pellikka; Richard J Rodeheffer; Virginia V Michels; Timothy M Olson
Journal:  J Am Coll Cardiol       Date:  2009-09-01       Impact factor: 24.094

7.  Dilated cardiomyopathy caused by tissue-specific ablation of SC35 in the heart.

Authors:  Jian-Hua Ding; Xiangdong Xu; Dongmei Yang; Pao-Hsien Chu; Nancy D Dalton; Zhen Ye; Joanne M Yeakley; Heping Cheng; Rui-Ping Xiao; John Ross; Ju Chen; Xiang-Dong Fu
Journal:  EMBO J       Date:  2004-02-12       Impact factor: 11.598

8.  Developmentally regulated switching of titin size alters myofibrillar stiffness in the perinatal heart.

Authors:  Christiane A Opitz; Mark C Leake; Irina Makarenko; Vladimir Benes; Wolfgang A Linke
Journal:  Circ Res       Date:  2004-02-26       Impact factor: 17.367

9.  Truncations of titin causing dilated cardiomyopathy.

Authors:  Daniel S Herman; Lien Lam; Matthew R G Taylor; Libin Wang; Polakit Teekakirikul; Danos Christodoulou; Lauren Conner; Steven R DePalma; Barbara McDonough; Elizabeth Sparks; Debbie Lin Teodorescu; Allison L Cirino; Nicholas R Banner; Dudley J Pennell; Sharon Graw; Marco Merlo; Andrea Di Lenarda; Gianfranco Sinagra; J Martijn Bos; Michael J Ackerman; Richard N Mitchell; Charles E Murry; Neal K Lakdawala; Carolyn Y Ho; Paul J R Barton; Stuart A Cook; Luisa Mestroni; J G Seidman; Christine E Seidman
Journal:  N Engl J Med       Date:  2012-02-16       Impact factor: 91.245

10.  Alternative isoform regulation in human tissue transcriptomes.

Authors:  Eric T Wang; Rickard Sandberg; Shujun Luo; Irina Khrebtukova; Lu Zhang; Christine Mayr; Stephen F Kingsmore; Gary P Schroth; Christopher B Burge
Journal:  Nature       Date:  2008-11-27       Impact factor: 49.962
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  8 in total

Review 1.  Global impact of RNA splicing on transcriptome remodeling in the heart.

Authors:  Chen Gao; Yibin Wang
Journal:  J Zhejiang Univ Sci B       Date:  2012-08       Impact factor: 3.066

Review 2.  Building robust transcriptomes with master splicing factors.

Authors:  Mohini Jangi; Phillip A Sharp
Journal:  Cell       Date:  2014-10-23       Impact factor: 41.582

3.  RBFox1-mediated RNA splicing regulates cardiac hypertrophy and heart failure.

Authors:  Chen Gao; Shuxun Ren; Jae-Hyung Lee; Jinsong Qiu; Douglas J Chapski; Christoph D Rau; Yu Zhou; Maha Abdellatif; Astushi Nakano; Thomas M Vondriska; Xinshu Xiao; Xiang-Dong Fu; Jau-Nian Chen; Yibin Wang
Journal:  J Clin Invest       Date:  2015-11-30       Impact factor: 14.808

Review 4.  Heart failure with preserved ejection fraction.

Authors:  James D Gladden; Wolfgang A Linke; Margaret M Redfield
Journal:  Pflugers Arch       Date:  2014-03-25       Impact factor: 3.657

5.  Dysregulated ribonucleoprotein granules promote cardiomyopathy in RBM20 gene-edited pigs.

Authors:  Jay W Schneider; Saji Oommen; Muhammad Y Qureshi; Sean C Goetsch; David R Pease; Rhianna S Sundsbak; Wei Guo; Mingming Sun; Han Sun; Hidehito Kuroyanagi; Dennis A Webster; Alexander W Coutts; Kimberly A Holst; Brooks S Edwards; Nikolas Newville; Matthew A Hathcock; Tamene Melkamu; Francesca Briganti; Wu Wei; Maria G Romanelli; Scott C Fahrenkrug; Doug E Frantz; Timothy M Olson; Lars M Steinmetz; Daniel F Carlson; Timothy J Nelson
Journal:  Nat Med       Date:  2020-11-13       Impact factor: 87.241

Review 6.  Heart failure with preserved ejection fraction.

Authors:  Ahmed ElGuindy; Magdi H Yacoub
Journal:  Glob Cardiol Sci Pract       Date:  2012-07-17

7.  The ryanodine receptor stabilizer S107 ameliorates contractility of adult Rbm20 knockout rat cardiomyocytes.

Authors:  Wei Guo; Chaoqun Zhu; Zhiyong Yin; Yanghai Zhang; Chunyan Wang; Andrea Sanchez Walk; Ying-Hsi Lin; Timothy A McKinsey; Kathleen C Woulfe; Jun Ren; Herbert G Chew
Journal:  Physiol Rep       Date:  2021-09

8.  Disulfide isomerization reactions in titin immunoglobulin domains enable a mode of protein elasticity.

Authors:  David Giganti; Kevin Yan; Carmen L Badilla; Julio M Fernandez; Jorge Alegre-Cebollada
Journal:  Nat Commun       Date:  2018-01-12       Impact factor: 14.919
  8 in total

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