Literature DB >> 22559289

Ion mobility separation of variant histone tails extending to the "middle-down" range.

Alexandre A Shvartsburg1, Yupeng Zheng, Richard D Smith, Neil L Kelleher.   

Abstract

Differential ion mobility spectrometry (FAIMS) can baseline-resolve multiple variants of post-translationally modified peptides extending to the 3-4 kDa range, which differ in the localization of a PTM as small as acetylation. Essentially orthogonal separations for different charge states expand the total peak capacity with the number of observed states that increases for longer polypeptides. This potentially enables resolving localization variants for yet larger peptides and even intact proteins.

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Year:  2012        PMID： 22559289      PMCID： PMC3353003          DOI： 10.1021/ac300612y

Source DB:  PubMed          Journal:  Anal Chem        ISSN： 0003-2700            Impact factor:   6.986


  36 in total

1.  Supercharged protein and peptide ions formed by electrospray ionization.

Authors:  A T Iavarone; J C Jurchen; E R Williams
Journal:  Anal Chem       Date:  2001-04-01       Impact factor: 6.986

2.  The language of covalent histone modifications.

Authors:  B D Strahl; C D Allis
Journal:  Nature       Date:  2000-01-06       Impact factor: 49.962

3.  Analysis of a tryptic digest of pig hemoglobin using ESI-FAIMS-MS.

Authors:  R Guevremont; D A Barnett; R W Purves; J Vandermey
Journal:  Anal Chem       Date:  2000-10-01       Impact factor: 6.986

4.  Investigation of bovine ubiquitin conformers separated by high-field asymmetric waveform ion mobility spectrometry: cross section measurements using energy-loss experiments with a triple quadrupole mass spectrometer.

Authors:  R W Purves; D A Barnett; B Ells; R Guevremont
Journal:  J Am Soc Mass Spectrom       Date:  2000-08       Impact factor: 3.109

5.  Phosphoproteome analysis by mass spectrometry and its application to Saccharomyces cerevisiae.

Authors:  Scott B Ficarro; Mark L McCleland; P Todd Stukenberg; Daniel J Burke; Mark M Ross; Jeffrey Shabanowitz; Donald F Hunt; Forest M White
Journal:  Nat Biotechnol       Date:  2002-03       Impact factor: 54.908

Review 6.  Translating the histone code.

Authors:  T Jenuwein; C D Allis
Journal:  Science       Date:  2001-08-10       Impact factor: 47.728

Review 7.  Proteomic analysis of post-translational modifications.

Authors:  Matthias Mann; Ole N Jensen
Journal:  Nat Biotechnol       Date:  2003-03       Impact factor: 54.908

Review 8.  High-field asymmetric waveform ion mobility spectrometry: a new tool for mass spectrometry.

Authors:  Roger Guevremont
Journal:  J Chromatogr A       Date:  2004-11-26       Impact factor: 4.759

9.  Two-dimensional gas-phase separations coupled to mass spectrometry for analysis of complex mixtures.

Authors:  Keqi Tang; Fumin Li; Alexandre A Shvartsburg; Eric F Strittmatter; Richard D Smith
Journal:  Anal Chem       Date:  2005-10-01       Impact factor: 6.986

10.  High-resolution differential ion mobility separations using planar analyzers at elevated dispersion fields.

Authors:  Alexandre A Shvartsburg; David C Prior; Keqi Tang; Richard D Smith
Journal:  Anal Chem       Date:  2010-09-15       Impact factor: 6.986
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  17 in total

1.  Pushing the Frontier of High-Definition Ion Mobility Spectrometry Using FAIMS.

Authors:  Alexandre A Shvartsburg; Gordon A Anderson; Richard D Smith
Journal:  Mass Spectrom (Tokyo)       Date:  2013-04-15

2.  Differential ion mobility separations in up to 100% helium using microchips.

Authors:  Alexandre A Shvartsburg; Yehia M Ibrahim; Richard D Smith
Journal:  J Am Soc Mass Spectrom       Date:  2014-01-09       Impact factor: 3.109

3.  A Novel Differential Ion Mobility Device Expands the Depth of Proteome Coverage and the Sensitivity of Multiplex Proteomic Measurements.

Authors:  Sibylle Pfammatter; Eric Bonneil; Francis P McManus; Satendra Prasad; Derek J Bailey; Michael Belford; Jean-Jacques Dunyach; Pierre Thibault
Journal:  Mol Cell Proteomics       Date:  2018-07-14       Impact factor: 5.911

4.  Separation of variant methylated histone tails by differential ion mobility.

Authors:  Alexandre A Shvartsburg; Yupeng Zheng; Richard D Smith; Neil L Kelleher
Journal:  Anal Chem       Date:  2012-07-18       Impact factor: 6.986

5.  Quantitation of Single and Combinatorial Histone Modifications by Integrated Chromatography of Bottom-up Peptides and Middle-down Polypeptide Tails.

Authors:  Kevin A Janssen; Mariel Coradin; Congcong Lu; Simone Sidoli; Benjamin A Garcia
Journal:  J Am Soc Mass Spectrom       Date:  2019-09-11       Impact factor: 3.109

6.  Separation of protein conformers by differential ion mobility in hydrogen-rich gases.

Authors:  Alexandre A Shvartsburg; Richard D Smith
Journal:  Anal Chem       Date:  2013-06-25       Impact factor: 6.986

7.  Broad Separation of Isomeric Lipids by High-Resolution Differential Ion Mobility Spectrometry with Tandem Mass Spectrometry.

Authors:  Andrew P Bowman; Rinat R Abzalimov; Alexandre A Shvartsburg
Journal:  J Am Soc Mass Spectrom       Date:  2017-05-01       Impact factor: 3.109

8.  Linear and Differential Ion Mobility Separations of Middle-Down Proteoforms.

Authors:  Alyssa Garabedian; Matthew A Baird; Jacob Porter; Kevin Jeanne Dit Fouque; Pavel V Shliaha; Ole N Jensen; Todd D Williams; Francisco Fernandez-Lima; Alexandre A Shvartsburg
Journal:  Anal Chem       Date:  2018-02-06       Impact factor: 6.986

9.  High-definition differential ion mobility spectrometry with resolving power up to 500.

Authors:  Alexandre A Shvartsburg; Tom A Seim; William F Danielson; Randy Norheim; Ronald J Moore; Gordon A Anderson; Richard D Smith
Journal:  J Am Soc Mass Spectrom       Date:  2012-12-20       Impact factor: 3.109

10.  Ion Mobility Separation of Peptide Isotopomers.

Authors:  Julia L Kaszycki; Andrew P Bowman; Alexandre A Shvartsburg
Journal:  J Am Soc Mass Spectrom       Date:  2016-03-04       Impact factor: 3.109
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