Literature DB >> 26944281

Ion Mobility Separation of Peptide Isotopomers.

Julia L Kaszycki1, Andrew P Bowman1, Alexandre A Shvartsburg2.   

Abstract

Differential or field asymmetric waveform ion mobility spectrometry (FAIMS) operating at high electric fields fully resolves isotopic isomers for a peptide with labeled residues. The naturally present isotopes, alone and together with targeted labels, also cause spectral shifts that approximately add for multiple heavy atoms. Separation qualitatively depends on the gas composition. These findings may enable novel strategies in proteomic and metabolomic analyses using stable isotope labeling.

Entities:  

Keywords:  Differential IMS (FAIMS); Ion mobility spectrometry; Isotopic analyses; Isotopomers

Mesh：

Substances：

Year:  2016        PMID： 26944281      PMCID： PMC5030822          DOI： 10.1007/s13361-016-1367-3

Source DB:  PubMed          Journal:  J Am Soc Mass Spectrom        ISSN： 1044-0305            Impact factor:   3.109


  25 in total

1.  Analysis of a tryptic digest of pig hemoglobin using ESI-FAIMS-MS.

Authors:  R Guevremont; D A Barnett; R W Purves; J Vandermey
Journal:  Anal Chem       Date:  2000-10-01       Impact factor: 6.986

Review 2.  13C metabolic flux analysis.

Authors:  W Wiechert
Journal:  Metab Eng       Date:  2001-07       Impact factor: 9.783

3.  Stable isotope labeling by amino acids in cell culture for quantitative proteomics.

Authors:  Shao-En Ong; Matthias Mann
Journal:  Methods Mol Biol       Date:  2007

4.  Separation of peptide isomers and conformers by ultra performance liquid chromatography.

Authors:  Dominic Winter; Rüdiger Pipkorn; Wolf D Lehmann
Journal:  J Sep Sci       Date:  2009-04       Impact factor: 3.645

5.  Peptide and protein quantification using iTRAQ with electron transfer dissociation.

Authors:  Doug Phanstiel; Yi Zhang; Jarrod A Marto; Joshua J Coon
Journal:  J Am Soc Mass Spectrom       Date:  2008-06-17       Impact factor: 3.109

6.  Differential ion mobility separations in up to 100% helium using microchips.

Authors:  Alexandre A Shvartsburg; Yehia M Ibrahim; Richard D Smith
Journal:  J Am Soc Mass Spectrom       Date:  2014-01-09       Impact factor: 3.109

7.  Understanding and designing field asymmetric waveform ion mobility spectrometry separations in gas mixtures.

Authors:  Alexandre A Shvartsburg; Keqi Tang; Richard D Smith
Journal:  Anal Chem       Date:  2004-12-15       Impact factor: 6.986

8.  Gas-phase separations of electrosprayed peptide libraries.

Authors:  C A Srebalus; J Li; W S Marshall; D E Clemmer
Journal:  Anal Chem       Date:  1999-09-15       Impact factor: 6.986

9.  Evaluation of carrier gases for use in high-field asymmetric waveform ion mobility spectrometry.

Authors:  D A Barnett; B Ells; R Guevremont; R W Purves; L A Viehland
Journal:  J Am Soc Mass Spectrom       Date:  2000-12       Impact factor: 3.109

10.  Counting individual sulfur atoms in a protein by ultrahigh-resolution Fourier transform ion cyclotron resonance mass spectrometry: experimental resolution of isotopic fine structure in proteins.

Authors:  S D Shi; C L Hendrickson; A G Marshall
Journal:  Proc Natl Acad Sci U S A       Date:  1998-09-29       Impact factor: 11.205
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  10 in total

1.  A Novel Differential Ion Mobility Device Expands the Depth of Proteome Coverage and the Sensitivity of Multiplex Proteomic Measurements.

Authors:  Sibylle Pfammatter; Eric Bonneil; Francis P McManus; Satendra Prasad; Derek J Bailey; Michael Belford; Jean-Jacques Dunyach; Pierre Thibault
Journal:  Mol Cell Proteomics       Date:  2018-07-14       Impact factor: 5.911

2.  Data Independent Acquisition Mass Spectrometry Method for Improved Neuropeptidomic Coverage in Crustacean Neural Tissue Extracts.

Authors:  Kellen DeLaney; Lingjun Li
Journal:  Anal Chem       Date:  2019-04-04       Impact factor: 6.986

3.  Towards the Analysis of High Molecular Weight Proteins and Protein complexes using TIMS-MS.

Authors:  Paolo Benigni; Rebecca Marin; Juan Camilo Molano-Arevalo; Alyssa Garabedian; Jeremy J Wolff; Mark E Ridgeway; Melvin A Park; Francisco Fernandez-Lima
Journal:  Int J Ion Mobil Spectrom       Date:  2016-06-07

4.  SLIM Ultrahigh Resolution Ion Mobility Spectrometry Separations of Isotopologues and Isotopomers Reveal Mobility Shifts due to Mass Distribution Changes.

Authors:  Roza Wojcik; Gabe Nagy; Isaac K Attah; Ian K Webb; Sandilya V B Garimella; Karl K Weitz; Adam Hollerbach; Matthew E Monroe; Marshall R Ligare; Felicity F Nielson; Randolph V Norheim; Ryan S Renslow; Thomas O Metz; Yehia M Ibrahim; Richard D Smith
Journal:  Anal Chem       Date:  2019-09-06       Impact factor: 6.986

5.  Broad Separation of Isomeric Lipids by High-Resolution Differential Ion Mobility Spectrometry with Tandem Mass Spectrometry.

Authors:  Andrew P Bowman; Rinat R Abzalimov; Alexandre A Shvartsburg
Journal:  J Am Soc Mass Spectrom       Date:  2017-05-01       Impact factor: 3.109

Review 6.  Coupling Front-End Separations, Ion Mobility Spectrometry, and Mass Spectrometry For Enhanced Multidimensional Biological and Environmental Analyses.

Authors:  Xueyun Zheng; Roza Wojcik; Xing Zhang; Yehia M Ibrahim; Kristin E Burnum-Johnson; Daniel J Orton; Matthew E Monroe; Ronald J Moore; Richard D Smith; Erin S Baker
Journal:  Annu Rev Anal Chem (Palo Alto Calif)       Date:  2017-02-23       Impact factor: 10.745

7.  Measurement and Theory of Gas-Phase Ion Mobility Shifts Resulting from Isotopomer Mass Distribution Changes.

Authors:  Christopher P Harrilal; Viraj D Gandhi; Gabe Nagy; Xi Chen; Michael G Buchanan; Roza Wojcik; Christopher R Conant; Micah T Donor; Yehia M Ibrahim; Sandilya V B Garimella; Richard D Smith; Carlos Larriba-Andaluz
Journal:  Anal Chem       Date:  2021-11-02       Impact factor: 8.008

8.  Ion Mobility Spectrometry: Fundamental Concepts, Instrumentation, Applications, and the Road Ahead.

Authors:  James N Dodds; Erin S Baker
Journal:  J Am Soc Mass Spectrom       Date:  2019-09-06       Impact factor: 3.109

9.  Protons Are Fast and Smart; Proteins Are Slow and Dumb: On the Relationship of Electrospray Ionization Charge States and Conformations.

Authors:  Shannon A Raab; Tarick J El-Baba; Arthur Laganowsky; David H Russell; Stephen J Valentine; David E Clemmer
Journal:  J Am Soc Mass Spectrom       Date:  2021-06-21       Impact factor: 3.262

Review 10.  Recommendations for reporting ion mobility Mass Spectrometry measurements.

Authors:  Valérie Gabelica; Alexandre A Shvartsburg; Carlos Afonso; Perdita Barran; Justin L P Benesch; Christian Bleiholder; Michael T Bowers; Aivett Bilbao; Matthew F Bush; J Larry Campbell; Iain D G Campuzano; Tim Causon; Brian H Clowers; Colin S Creaser; Edwin De Pauw; Johann Far; Francisco Fernandez-Lima; John C Fjeldsted; Kevin Giles; Michael Groessl; Christopher J Hogan; Stephan Hann; Hugh I Kim; Ruwan T Kurulugama; Jody C May; John A McLean; Kevin Pagel; Keith Richardson; Mark E Ridgeway; Frédéric Rosu; Frank Sobott; Konstantinos Thalassinos; Stephen J Valentine; Thomas Wyttenbach
Journal:  Mass Spectrom Rev       Date:  2019-02-01       Impact factor: 10.946
  10 in total

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