Literature DB >> 22553960

Strained ruthenium complexes are potent light-activated anticancer agents.

Brock S Howerton1, David K Heidary, Edith C Glazer.   

Abstract

Strained ruthenium (Ru) complexes have been synthesized and characterized as novel agents for photodynamic therapy (PDT). The complexes are inert until triggered by visible light, which induces ligand loss and covalent modification of DNA. An increase in cytotoxicity of 2 orders of magnitude is observed with light activation in cancer cells, and the compounds display potencies superior to cisplatin against 3D tumor spheroids. The use of intramolecular strain may be applied as a general paradigm to develop light-activated ruthenium complexes for PDT applications.

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Year:  2012        PMID： 22553960     DOI： 10.1021/ja3009677

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  92 in total

1.  New Ru(II) Complex for Dual Activity: Photoinduced Ligand Release and (1)O2 Production.

Authors:  Lauren M Loftus; Jessica K White; Bryan A Albani; Lars Kohler; Jeremy J Kodanko; Randolph P Thummel; Kim R Dunbar; Claudia Turro
Journal:  Chemistry       Date:  2016-01-20       Impact factor: 5.236

2.  Control and utilization of ruthenium and rhodium metal complex excited states for photoactivated cancer therapy.

Authors:  Jessica D Knoll; Claudia Turro
Journal:  Coord Chem Rev       Date:  2015-01-01       Impact factor: 22.315

3.  Effects of Methyl Substitution in Ruthenium Tris(2-pyridylmethyl)amine Photocaging Groups for Nitriles.

Authors:  Karan Arora; Jessica K White; Rajgopal Sharma; Shivnath Mazumder; Philip D Martin; H Bernhard Schlegel; Claudia Turro; Jeremy J Kodanko
Journal:  Inorg Chem       Date:  2016-06-29       Impact factor: 5.165

4.  Geometry matters: inverse cytotoxic relationship for cis/trans-Ru(ii) polypyridyl complexes from cis/trans-[PtCl2(NH3)2].

Authors:  Erin Wachter; Ana Zamora; David K Heidary; José Ruiz; Edith C Glazer
Journal:  Chem Commun (Camb)       Date:  2016-08-09       Impact factor: 6.222

5.  An Overview Of Photosubstitution Reactions Of Ru(II) Imine Complexes And Their Application In Photobiology And Photodynamic Therapy.

Authors:  Jessica K White; Russell H Schmehl; Claudia Turro
Journal:  Inorganica Chim Acta       Date:  2016-06-18       Impact factor: 2.545

6.  Light-activated protein inhibition through photoinduced electron transfer of a ruthenium(II)-cobalt(III) bimetallic complex.

Authors:  Robert J Holbrook; David J Weinberg; Mark D Peterson; Emily A Weiss; Thomas J Meade
Journal:  J Am Chem Soc       Date:  2015-03-02       Impact factor: 15.419

7.  New Ru(II) complexes for dual photoreactivity: ligand exchange and (1)O2 generation.

Authors:  Jessica D Knoll; Bryan A Albani; Claudia Turro
Journal:  Acc Chem Res       Date:  2015-07-17       Impact factor: 22.384

8.  Catch and Release Photosensitizers: Combining Dual-Action Ruthenium Complexes with Protease Inactivation for Targeting Invasive Cancers.

Authors:  Karan Arora; Mackenzie Herroon; Malik H Al-Afyouni; Nicholas P Toupin; Thomas N Rohrabaugh; Lauren M Loftus; Izabela Podgorski; Claudia Turro; Jeremy J Kodanko
Journal:  J Am Chem Soc       Date:  2018-10-22       Impact factor: 15.419

9.  Excited state investigation of a new Ru(II) complex for dual reactivity with low energy light.

Authors:  J D Knoll; B A Albani; C Turro
Journal:  Chem Commun (Camb)       Date:  2015-05-25       Impact factor: 6.222

10.  Os(II) Oligothienyl Complexes as a Hypoxia-Active Photosensitizer Class for Photodynamic Therapy.

Authors:  John A Roque; Patrick C Barrett; Houston D Cole; Liubov M Lifshits; Evan Bradner; Ge Shi; David von Dohlen; Susy Kim; Nino Russo; Gagan Deep; Colin G Cameron; Marta E Alberto; Sherri A McFarland
Journal:  Inorg Chem       Date:  2020-10-30       Impact factor: 5.165
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