Literature DB >> 22553331

Corneal replication is an interferon response-independent bottleneck for virulence of herpes simplex virus 1 in the absence of virion host shutoff.

Tracy Jo Pasieka1, Vineet D Menachery, Pamela C Rosato, David A Leib.   

Abstract

Herpes simplex viruses lacking the virion host shutoff function (Δvhs) are avirulent and hypersensitive to type I and type II interferon (IFN). In this study, we demonstrate that even in the absence of IFN responses in AG129 (IFN-αβγR(-/-)) mice, Δvhs remains highly attenuated via corneal infection but is fully virulent via intracranial infection. The data demonstrate that the interferon-independent inherent replication defect of Δvhs has a significant impact upon peripheral replication and neuroinvasion.

Entities:  

Mesh：

Substances：

Year:  2012        PMID： 22553331      PMCID： PMC3416281          DOI： 10.1128/JVI.00761-12

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  33 in total

1.  The virion host shutoff protein (UL41) of herpes simplex virus 1 is an endoribonuclease with a substrate specificity similar to that of RNase A.

Authors:  Brunella Taddeo; Bernard Roizman
Journal:  J Virol       Date:  2006-09       Impact factor: 5.103

2.  The U(L)41 protein of herpes simplex virus 1 degrades RNA by endonucleolytic cleavage in absence of other cellular or viral proteins.

Authors:  Brunella Taddeo; Weiran Zhang; Bernard Roizman
Journal:  Proc Natl Acad Sci U S A       Date:  2006-02-13       Impact factor: 11.205

3.  Functional genomics reveals an essential and specific role for Stat1 in protection of the central nervous system following herpes simplex virus corneal infection.

Authors:  Tracy Jo Pasieka; Cristian Cilloniz; Victoria S Carter; Pamela Rosato; Michael G Katze; David A Leib
Journal:  J Virol       Date:  2011-10-12       Impact factor: 5.103

4.  Selective ablation of virion host shutoff protein RNase activity attenuates herpes simplex virus 2 in mice.

Authors:  Maria Korom; Kristine M Wylie; Lynda A Morrison
Journal:  J Virol       Date:  2008-01-30       Impact factor: 5.103

5.  Herpes simplex virus virion host shutoff attenuates establishment of the antiviral state.

Authors:  Tracy Jo Pasieka; Betty Lu; Seth D Crosby; Kristine M Wylie; Lynda A Morrison; Diane E Alexander; Vineet D Menachery; David A Leib
Journal:  J Virol       Date:  2008-03-26       Impact factor: 5.103

6.  Enhanced pathogenesis of an attenuated herpes simplex virus for mice lacking Stat1.

Authors:  Tracy Jo Pasieka; Betty Lu; David A Leib
Journal:  J Virol       Date:  2008-04-09       Impact factor: 5.103

7.  Host responses to wild-type and attenuated herpes simplex virus infection in the absence of Stat1.

Authors:  Tracy Jo Pasieka; Cristian Cilloniz; Betty Lu; Thomas H Teal; Sean C Proll; Michael G Katze; David A Leib
Journal:  J Virol       Date:  2008-12-24       Impact factor: 5.103

8.  Infection of mature dendritic cells with herpes simplex virus type 1 interferes with the interferon signaling pathway.

Authors:  Jutta Eisemann; Petra Mühl-Zürbes; Alexander Steinkasserer; Mirko Kummer
Journal:  Immunobiology       Date:  2007-11-09       Impact factor: 3.144

9.  Herpes simplex virus encephalitis in human UNC-93B deficiency.

Authors:  Armanda Casrouge; Shen-Ying Zhang; Céline Eidenschenk; Emmanuelle Jouanguy; Anne Puel; Kun Yang; Alexandre Alcais; Capucine Picard; Nora Mahfoufi; Nathalie Nicolas; Lazaro Lorenzo; Sabine Plancoulaine; Brigitte Sénéchal; Frédéric Geissmann; Koichi Tabeta; Kasper Hoebe; Xin Du; Richard L Miller; Bénédicte Héron; Cyril Mignot; Thierry Billette de Villemeur; Pierre Lebon; Olivier Dulac; Flore Rozenberg; Bruce Beutler; Marc Tardieu; Laurent Abel; Jean-Laurent Casanova
Journal:  Science       Date:  2006-09-14       Impact factor: 47.728

10.  Multiple host barriers restrict poliovirus trafficking in mice.

Authors:  Sharon K Kuss; Chris A Etheredge; Julie K Pfeiffer
Journal:  PLoS Pathog       Date:  2008-06-06       Impact factor: 6.823
View more
  8 in total

1.  Role of the DNA Sensor STING in Protection from Lethal Infection following Corneal and Intracerebral Challenge with Herpes Simplex Virus 1.

Authors:  Zachary M Parker; Aisling A Murphy; David A Leib
Journal:  J Virol       Date:  2015-08-26       Impact factor: 5.103

2.  Neurons versus herpes simplex virus: the innate immune interactions that contribute to a host-pathogen standoff.

Authors:  Pamela C Rosato; David A Leib
Journal:  Future Virol       Date:  2015-06       Impact factor: 1.831

3.  Synergistic control of herpes simplex virus pathogenesis by IRF-3, and IRF-7 revealed through non-invasive bioluminescence imaging.

Authors:  Aisling A Murphy; Pamela C Rosato; Zachary M Parker; Alexey Khalenkov; David A Leib
Journal:  Virology       Date:  2013-06-16       Impact factor: 3.616

4.  Immune- and Nonimmune-Compartment-Specific Interferon Responses Are Critical Determinants of Herpes Simplex Virus-Induced Generalized Infections and Acute Liver Failure.

Authors:  Zachary M Parker; Tracy Jo Pasieka; George A Parker; David A Leib
Journal:  J Virol       Date:  2016-11-14       Impact factor: 5.103

5.  The Splicing History of an mRNA Affects Its Level of Translation and Sensitivity to Cleavage by the Virion Host Shutoff Endonuclease during Herpes Simplex Virus Infections.

Authors:  Jouliana Sadek; G Sullivan Read
Journal:  J Virol       Date:  2016-11-14       Impact factor: 5.103

6.  A bright future for bioluminescent imaging in viral research.

Authors:  Stewart M Coleman; Alistair McGregor
Journal:  Future Virol       Date:  2015       Impact factor: 1.831

7.  Neuronal Subtype Determines Herpes Simplex Virus 1 Latency-Associated-Transcript Promoter Activity during Latency.

Authors:  Jorge Ruben Cabrera; Audra J Charron; David A Leib
Journal:  J Virol       Date:  2018-06-13       Impact factor: 5.103

8.  A bimodal switch in global protein translation coupled to eIF4H relocalisation during advancing cell-cell transmission of herpes simplex virus.

Authors:  Catherine Su Hui Teo; Peter O'Hare
Journal:  PLoS Pathog       Date:  2018-07-20       Impact factor: 6.823
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.