Literature DB >> 18400863

Enhanced pathogenesis of an attenuated herpes simplex virus for mice lacking Stat1.

Tracy Jo Pasieka1, Betty Lu, David A Leib.   

Abstract

Mice lacking the Stat1 interferon signaling gene were infected with herpes simplex virus type 1 (HSV-1) or an attenuated recombinant lacking virion host shutoff (Delta vhs). Delta vhs virus-infected Stat1(-/-) mice showed levels of replication equivalent to that of the wild-type virus-infected control mice but reduced relative to wild-type virus-infected Stat1(-/-) mice. Stat1 deficiency relieves the immunomodulatory deficiency of Delta vhs virus, but not its inherent growth defect. Also Vhs is dispensable for reactivation.

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Year:  2008        PMID： 18400863      PMCID： PMC2395151          DOI： 10.1128/JVI.00297-08

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  29 in total

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Authors:  Stephanie M Karst; Christiane E Wobus; Margarita Lay; John Davidson; Herbert W Virgin
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2.  RNase L activity does not contribute to host RNA degradation induced by herpes simplex virus infection.

Authors:  Tracy J Smith; Robert H Silverman; David A Leib
Journal:  J Gen Virol       Date:  2003-04       Impact factor: 3.891

3.  The herpes simplex virus virion host shutoff function.

Authors:  A D Kwong; N Frenkel
Journal:  J Virol       Date:  1989-11       Impact factor: 5.103

4.  Herpes simplex virus-infected cells contain a function(s) that destabilizes both host and viral mRNAs.

Authors:  A D Kwong; N Frenkel
Journal:  Proc Natl Acad Sci U S A       Date:  1987-04       Impact factor: 11.205

5.  In vivo characterization of site-directed mutations in the promoter of the herpes simplex virus type 1 latency-associated transcripts.

Authors:  K A Rader; C E Ackland-Berglund; J K Miller; J S Pepose; D A Leib
Journal:  J Gen Virol       Date:  1993-09       Impact factor: 3.891

6.  Herpes simplex virus mutants defective in the virion-associated shutoff of host polypeptide synthesis and exhibiting abnormal synthesis of alpha (immediate early) viral polypeptides.

Authors:  G S Read; N Frenkel
Journal:  J Virol       Date:  1983-05       Impact factor: 5.103

7.  Impaired response to interferon-alpha/beta and lethal viral disease in human STAT1 deficiency.

Authors:  Stéphanie Dupuis; Emmanuelle Jouanguy; Sami Al-Hajjar; Claire Fieschi; Ibrahim Zaid Al-Mohsen; Suliman Al-Jumaah; Kun Yang; Ariane Chapgier; Céline Eidenschenk; Pierre Eid; Abdulaziz Al Ghonaium; Haysam Tufenkeji; Husn Frayha; Suleiman Al-Gazlan; Hassan Al-Rayes; Robert D Schreiber; Ion Gresser; Jean-Laurent Casanova
Journal:  Nat Genet       Date:  2003-02-18       Impact factor: 38.330

8.  Pathogenesis of herpes simplex virus type 2 virion host shutoff (vhs) mutants.

Authors:  Tracy J Smith; Lynda A Morrison; David A Leib
Journal:  J Virol       Date:  2002-03       Impact factor: 5.103

9.  Therapeutic vaccination with vhs(-) herpes simplex virus reduces the severity of recurrent herpetic stromal keratitis in mice.

Authors:  Tammie L Keadle; Keith A Laycock; Jessica L Morris; David A Leib; Lynda A Morrison; Jay S Pepose; Patrick M Stuart
Journal:  J Gen Virol       Date:  2002-10       Impact factor: 3.891

10.  Herpes simplex virus 2 virion host shutoff protein interferes with type I interferon production and responsiveness.

Authors:  Rebecca J Duerst; Lynda A Morrison
Journal:  Virology       Date:  2004-04-25       Impact factor: 3.616
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  23 in total

1.  The virion host shutoff endonuclease (UL41) of herpes simplex virus interacts with the cellular cap-binding complex eIF4F.

Authors:  Heidi G Page; G Sullivan Read
Journal:  J Virol       Date:  2010-04-28       Impact factor: 5.103

2.  Cellular Protein WDR11 Interacts with Specific Herpes Simplex Virus Proteins at the trans-Golgi Network To Promote Virus Replication.

Authors:  Kathryne E Taylor; Karen L Mossman
Journal:  J Virol       Date:  2015-07-15       Impact factor: 5.103

3.  The differential interferon responses of two strains of Stat1-deficient mice do not alter susceptibility to HSV-1 and VSV in vivo.

Authors:  Sarah Katzenell; Yufei Chen; Zachary M Parker; David A Leib
Journal:  Virology       Date:  2014-01-14       Impact factor: 3.616

4.  mRNA decay during herpes simplex virus (HSV) infections: mutations that affect translation of an mRNA influence the sites at which it is cleaved by the HSV virion host shutoff (Vhs) protein.

Authors:  Lora A Shiflett; G Sullivan Read
Journal:  J Virol       Date:  2012-10-17       Impact factor: 5.103

5.  DNA damage promotes herpes simplex virus-1 protein expression in a neuroblastoma cell line.

Authors:  Ketna Volcy; Nigel W Fraser
Journal:  J Neurovirol       Date:  2013-01-26       Impact factor: 2.643

6.  Neurons versus herpes simplex virus: the innate immune interactions that contribute to a host-pathogen standoff.

Authors:  Pamela C Rosato; David A Leib
Journal:  Future Virol       Date:  2015-06       Impact factor: 1.831

7.  Synergistic control of herpes simplex virus pathogenesis by IRF-3, and IRF-7 revealed through non-invasive bioluminescence imaging.

Authors:  Aisling A Murphy; Pamela C Rosato; Zachary M Parker; Alexey Khalenkov; David A Leib
Journal:  Virology       Date:  2013-06-16       Impact factor: 3.616

8.  The Herpes Simplex Virus Virion Host Shutoff Protein Enhances Translation of Viral True Late mRNAs Independently of Suppressing Protein Kinase R and Stress Granule Formation.

Authors:  Bianca Dauber; David Poon; Theodore Dos Santos; Brett A Duguay; Ninad Mehta; Holly A Saffran; James R Smiley
Journal:  J Virol       Date:  2016-06-10       Impact factor: 5.103

9.  Herpes simplex virus type 1 regulatory protein ICP0 aids infection in cells with a preinduced interferon response but does not impede interferon-induced gene induction.

Authors:  Roger D Everett; Anne Orr
Journal:  J Virol       Date:  2009-03-04       Impact factor: 5.103

10.  Host responses to wild-type and attenuated herpes simplex virus infection in the absence of Stat1.

Authors:  Tracy Jo Pasieka; Cristian Cilloniz; Betty Lu; Thomas H Teal; Sean C Proll; Michael G Katze; David A Leib
Journal:  J Virol       Date:  2008-12-24       Impact factor: 5.103
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