BACKGROUND: Genetic polymorphisms of transcription factor 7-like 2 (TCF7L2) have been associated with type 2 diabetes and BMI. OBJECTIVE: The objective was to investigate whether TCF7L2 HapA is associated with weight development and whether such an association is modulated by protein intake or by the glycemic index (GI). DESIGN: The investigation was based on prospective data from 5 cohort studies nested within the European Prospective Investigation into Cancer and Nutrition. Weight change was followed up for a mean (±SD) of 6.8 ± 2.5 y. TCF7L2 rs7903146 and rs10885406 were successfully genotyped in 11,069 individuals and used to derive HapA. Multiple logistic and linear regression analysis was applied to test for the main effect of HapA and its interaction with dietary protein or GI. Analyses from the cohorts were combined by random-effects meta-analysis. RESULTS: HapA was associated neither with baseline BMI (0.03 ± 0.07 BMI units per allele; P = 0.6) nor with annual weight change (8.8 ± 11.7 g/y per allele; P = 0.5). However, a previously shown positive association between intake of protein, particularly of animal origin, and subsequent weight change in this population proved to be attenuated by TCF7L2 HapA (P-interaction = 0.01). We showed that weight gain becomes independent of protein intake with an increasing number of HapA alleles. Substitution of protein with either fat or carbohydrates showed the same effects. No interaction with GI was observed. CONCLUSION: TCF7L2 HapA attenuates the positive association between animal protein intake and long-term body weight change in middle-aged Europeans but does not interact with the GI of the diet.
BACKGROUND: Genetic polymorphisms of transcription factor 7-like 2 (TCF7L2) have been associated with type 2 diabetes and BMI. OBJECTIVE: The objective was to investigate whether TCF7L2 HapA is associated with weight development and whether such an association is modulated by protein intake or by the glycemic index (GI). DESIGN: The investigation was based on prospective data from 5 cohort studies nested within the European Prospective Investigation into Cancer and Nutrition. Weight change was followed up for a mean (±SD) of 6.8 ± 2.5 y. TCF7L2rs7903146 and rs10885406 were successfully genotyped in 11,069 individuals and used to derive HapA. Multiple logistic and linear regression analysis was applied to test for the main effect of HapA and its interaction with dietary protein or GI. Analyses from the cohorts were combined by random-effects meta-analysis. RESULTS: HapA was associated neither with baseline BMI (0.03 ± 0.07 BMI units per allele; P = 0.6) nor with annual weight change (8.8 ± 11.7 g/y per allele; P = 0.5). However, a previously shown positive association between intake of protein, particularly of animal origin, and subsequent weight change in this population proved to be attenuated by TCF7L2 HapA (P-interaction = 0.01). We showed that weight gain becomes independent of protein intake with an increasing number of HapA alleles. Substitution of protein with either fat or carbohydrates showed the same effects. No interaction with GI was observed. CONCLUSION:TCF7L2 HapA attenuates the positive association between animal protein intake and long-term body weight change in middle-aged Europeans but does not interact with the GI of the diet.
Authors: Ana Barabash; Johanna D Valerio; Nuria Garcia de la Torre; Inés Jimenez; Laura Del Valle; Verónica Melero; Carla Assaf-Balut; Manuel Fuentes; Elena Bordiu; Alejandra Durán; Miguel A Herraiz; Nuria Izquierdo; María J Torrejón; Paz de Miguel; Isabelle Runkle; Miguel A Rubio; Alfonso L Calle-Pascual Journal: Metabol Open Date: 2020-11-26
Authors: Mikkel Z Ankarfeldt; Sofus C Larsen; Lars Ängquist; Lise Lotte N Husemoen; Nina Roswall; Kim Overvad; Marianne Uhre Jakobsen; Jytte Halkjær; Anne Tjønneland; Allan Linneberg; Ulla Toft; Torben Hansen; Oluf Pedersen; Berit L Heitmann; Arne Astrup; Thorkild I A Sørensen Journal: PLoS One Date: 2014-10-28 Impact factor: 3.240
Authors: Karina Meidtner; Eva Fisher; Lars Angquist; Claus Holst; Karani S Vimaleswaran; Jolanda M A Boer; Jytte Halkjær; Giovanna Masala; Jane N Ostergaard; Lotte M Mortensen; Daphne L van der A; Anne Tjønneland; Domenico Palli; Kim Overvad; Nicholas J Wareham; Ruth J F Loos; Thorkild I A Sørensen; Heiner Boeing Journal: Genes Nutr Date: 2014-02-05 Impact factor: 5.523
Authors: Dolores Corella; Paula Carrasco; Jose V Sorlí; Ramón Estruch; Jesús Rico-Sanz; Miguel Ángel Martínez-González; Jordi Salas-Salvadó; M Isabel Covas; Oscar Coltell; Fernando Arós; José Lapetra; Lluís Serra-Majem; Valentina Ruiz-Gutiérrez; Julia Warnberg; Miquel Fiol; Xavier Pintó; Carolina Ortega-Azorín; Miguel Ángel Muñoz; J Alfredo Martínez; Enrique Gómez-Gracia; José I González; Emilio Ros; José M Ordovás Journal: Diabetes Care Date: 2013-08-13 Impact factor: 19.112