OBJECTIVE: Neuropeptide S receptor 1 (NPSR1) is a G protein-coupled receptor involved in immune response and is associated with several inflammatory diseases. We investigated the possible contribution of several polymorphisms in the intronic region of NPSR1 to rheumatoid arthritis (RA). METHODS: Genotyping of 7 single-nucleotide polymorphisms (SNP) was performed in a total of 1232 patients with RA and 983 healthy controls of Spanish white origin by real-time polymerase chain reaction technology, using the TaqMan 5'-allele discrimination assay. RESULTS: One out of the 7 SNP analyzed (rs740347) was associated with RA [p after Bonferroni correction (p(BNF)) = 1.2 × 10(-3), OR 0.73]. An association was also observed with rheumatoid factor-positive and shared epitope-positive RA (p(BNF) = 0.011, OR 0.73; p(BNF) = 0.037, OR 0.75, respectively). CONCLUSION: Our results show that variations in the NPSR1 intronic region are associated with low risk in patients with RA, supporting other evidence that this locus represents a common genetic factor in inflammatory diseases.
OBJECTIVE:Neuropeptide S receptor 1 (NPSR1) is a G protein-coupled receptor involved in immune response and is associated with several inflammatory diseases. We investigated the possible contribution of several polymorphisms in the intronic region of NPSR1 to rheumatoid arthritis (RA). METHODS: Genotyping of 7 single-nucleotide polymorphisms (SNP) was performed in a total of 1232 patients with RA and 983 healthy controls of Spanish white origin by real-time polymerase chain reaction technology, using the TaqMan 5'-allele discrimination assay. RESULTS: One out of the 7 SNP analyzed (rs740347) was associated with RA [p after Bonferroni correction (p(BNF)) = 1.2 × 10(-3), OR 0.73]. An association was also observed with rheumatoid factor-positive and shared epitope-positive RA (p(BNF) = 0.011, OR 0.73; p(BNF) = 0.037, OR 0.75, respectively). CONCLUSION: Our results show that variations in the NPSR1 intronic region are associated with low risk in patients with RA, supporting other evidence that this locus represents a common genetic factor in inflammatory diseases.
Authors: Nathalie Acevedo; Sini Ezer; Simon Kebede Merid; Vincent D Gaertner; Cilla Söderhäll; Mauro D'Amato; Michael Kabesch; Erik Melén; Juha Kere; Ville Pulkkinen Journal: PLoS One Date: 2017-05-02 Impact factor: 3.240
Authors: Nathalie Acevedo; Annika Sääf; Cilla Söderhäll; Erik Melén; Jami Mandelin; Christina Orsmark Pietras; Sini Ezer; Piia Karisola; Johanna Vendelin; Gustav Boije af Gennäs; Jari Yli-Kauhaluoma; Harri Alenius; Erika von Mutius; Gert Doekes; Charlotte Braun-Fahrländer; Josef Riedler; Marianne van Hage; Mauro D'Amato; Annika Scheynius; Göran Pershagen; Juha Kere; Ville Pulkkinen Journal: PLoS One Date: 2013-04-02 Impact factor: 3.240
Authors: V Pulkkinen; S Ezer; L Sundman; J Hagström; S Remes; C Söderhäll; D Greco; G Dario; C Haglund; J Kere; J Arola Journal: Virchows Arch Date: 2014-06-12 Impact factor: 4.064