Literature DB >> 33922620

Pharmacology, Physiology and Genetics of the Neuropeptide S System.

Rainer K Reinscheid1,2, Chiara Ruzza3.   

Abstract

The Neuropeptide S (NPS) system is a rather 'young' transmitter system that was discovered and functionally described less than 20 years ago. This review highlights the progress that has been made in elucidating its pharmacology, anatomical distribution, and functional involvement in a variety of physiological effects, including behavior and immune functions. Early on, genetic variations of the human NPS receptor (NPSR1) have attracted attention and we summarize current hypotheses of genetic linkage with disease and human behaviors. Finally, we review the therapeutic potential of future drugs modulating NPS signaling. This review serves as an introduction to the broad collection of original research papers and reviews from experts in the field that are presented in this Special Issue.

Entities:  

Keywords:  GPCR; anxiety; brainstem; genetic variation; memory; transmitter

Year:  2021        PMID： 33922620     DOI： 10.3390/ph14050401

Source DB:  PubMed          Journal:  Pharmaceuticals (Basel)        ISSN： 1424-8247


  119 in total

1.  Abnormal response to stress and impaired NPS-induced hyperlocomotion, anxiolytic effect and corticosterone increase in mice lacking NPSR1.

Authors:  Hongyan Zhu; Melissa K Mingler; Melissa L McBride; Andrew J Murphy; David M Valenzuela; George D Yancopoulos; Michael T Williams; Charles V Vorhees; Marc E Rothenberg
Journal:  Psychoneuroendocrinology       Date:  2010-02-19       Impact factor: 4.905

2.  Mutant neuropeptide S receptor reduces sleep duration with preserved memory consolidation.

Authors:  Lijuan Xing; Guangsen Shi; Yulia Mostovoy; Nicholas W Gentry; Zenghua Fan; Thomas B McMahon; Pui-Yan Kwok; Christopher R Jones; Louis J Ptáček; Ying-Hui Fu
Journal:  Sci Transl Med       Date:  2019-10-16       Impact factor: 17.956

3.  Association of G-protein-coupled receptor 154 with asthma and total IgE in a population of the Caribbean coast of Colombia.

Authors:  C Vergara; S Jiménez; N Acevedo; B Martínez; D Mercado; L Gusmão; N Rafaels; T Hand; K C Barnes; L Caraballo
Journal:  Clin Exp Allergy       Date:  2009-07-16       Impact factor: 5.018

4.  Neuropeptide S and G protein-coupled receptor 154 modulate macrophage immune responses.

Authors:  Ville Pulkkinen; Marja-Leena Majuri; Guoying Wang; Päivi Holopainen; Yasushi Obase; Johanna Vendelin; Henrik Wolff; Paula Rytilä; Lauri A Laitinen; Tari Haahtela; Tarja Laitinen; Harri Alenius; Juha Kere; Marko Rehn
Journal:  Hum Mol Genet       Date:  2006-04-06       Impact factor: 6.150

5.  Neuropeptide S precursor knockout mice display memory and arousal deficits.

Authors:  Xiaobin Liu; Wei Si; Celia Garau; Kay Jüngling; Hans-Christian Pape; Stefan Schulz; Rainer K Reinscheid
Journal:  Eur J Neurosci       Date:  2017-06-21       Impact factor: 3.386

6.  Phylogenetic appearance of neuropeptide S precursor proteins in tetrapods.

Authors:  Rainer K Reinscheid
Journal:  Peptides       Date:  2007-01-20       Impact factor: 3.750

7.  Synthesis and evaluation of a new series of Neuropeptide S receptor antagonists.

Authors:  Jeffrey Y Melamed; Amy E Zartman; Nathan R Kett; Anthony L Gotter; Victor N Uebele; Duane R Reiss; Cindra L Condra; Christine Fandozzi; Laura S Lubbers; Blake A Rowe; Georgia B McGaughey; Martin Henault; Rino Stocco; John J Renger; George D Hartman; Mark T Bilodeau; B Wesley Trotter
Journal:  Bioorg Med Chem Lett       Date:  2010-05-05       Impact factor: 2.823

8.  Immunohistochemical localization of the neuropeptide S receptor in the rat central nervous system.

Authors:  S K Leonard; R H Ring
Journal:  Neuroscience       Date:  2010-10-13       Impact factor: 3.590

9.  Behavioral phenotyping of neuropeptide S receptor knockout mice.

Authors:  Dee M Duangdao; Stewart D Clark; Naoe Okamura; Rainer K Reinscheid
Journal:  Behav Brain Res       Date:  2009-07-29       Impact factor: 3.332

10.  Synthesis and biological activity of human neuropeptide S analogues modified in position 5: identification of potent and pure neuropeptide S receptor antagonists.

Authors:  Remo Guerrini; Valeria Camarda; Claudio Trapella; Girolamo Calò; Anna Rizzi; Chiara Ruzza; Stella Fiorini; Erika Marzola; Rainer K Reinscheid; Domenico Regoli; Severo Salvadori
Journal:  J Med Chem       Date:  2009-01-22       Impact factor: 7.446
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  3 in total

1.  Effect of Escitalopram on the Number of DCX-Positive Cells and NMUR2 Receptor Expression in the Rat Hippocampus under the Condition of NPSR Receptor Blockade.

Authors:  Aneta Piwowarczyk-Nowak; Artur Pałasz; Aleksandra Suszka-Świtek; Iwona Błaszczyk; Katarzyna Bogus; Barbara Łasut-Szyszka; Marek Krzystanek; John J Worthington
Journal:  Pharmaceuticals (Basel)       Date:  2022-05-20

Review 2.  Can Neuropeptide S Be an Indicator for Assessing Anxiety in Psychiatric Disorders?

Authors:  Agnieszka Markiewicz-Gospodarek; Piotr Kuszta; Jacek Baj; Beata Dobrowolska; Renata Markiewicz
Journal:  Front Public Health       Date:  2022-04-26

Review 3.  Roles of Neuropeptide S in Anesthesia, Analgesia, and Sleep.

Authors:  Tetsuya Kushikata; Kazuyoshi Hirota; Junichi Saito; Daiki Takekawa
Journal:  Pharmaceuticals (Basel)       Date:  2021-05-19
  3 in total

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