Literature DB >> 22546285

Regulation of intestinal cancer stem cells.

Neil Ashley1.   

Abstract

Colorectal tumours harbour a sub-population of cells with stem like properties termed 'cancer stem cells', which are believed to ultimately drive cancer growth. This review discusses recent advances in our understanding of both normal and cancer intestinal stem cells, with emphasis on similarities and differences. Specifically we discuss the role of the Wnt, Notch and BMP pathways and their roles in both stem cell proliferation and differentiation. Furthermore we discuss the emerging role of microRNA and the influence of environmental factors such as tumour associated myofibroblasts and hypoxia on cancer stem cell regulation.
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Entities:  

Keywords:  BMP; Colon; Differentiation; Hypoxia; Myofibroblasts; Notch; Regulation; Stem cells; Wnt

Mesh：

Substances：

Year:  2012        PMID： 22546285     DOI： 10.1016/j.canlet.2012.04.016

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  12 in total

1.  Deletion of Ptp4a3 reduces clonogenicity and tumor-initiation ability of colitis-associated cancer cells in mice.

Authors:  Julie M Cramer; Mark W Zimmerman; Tim Thompson; Gregg E Homanics; John S Lazo; Eric Lagasse
Journal:  Stem Cell Res       Date:  2014-05-27       Impact factor: 2.020

2.  In rectal cancer, the type of desmoplastic response after preoperative chemoradiotherapy is associated with prognosis.

Authors:  Hideki Ueno; Eiji Shinto; Yojiro Hashiguchi; Hideyuki Shimazaki; Yoshiki Kajiwara; Takahiro Sueyama; Junji Yamamoto; Kazuo Hase
Journal:  Virchows Arch       Date:  2015-03-29       Impact factor: 4.064

3.  Production of Tissue-Engineered Small Intestine in Rats with Different Ages of Cell Donors.

Authors:  Yanchun Liu; Yijie Wang; Jason Chakroff; Jed Johnson; Aidan Farrell; Gail E Besner
Journal:  Tissue Eng Part A       Date:  2018-11-07       Impact factor: 3.845

4.  Cancer Stem Cells: A Moving Target.

Authors:  Maria Giovanna Francipane; Julie Chandler; Eric Lagasse
Journal:  Curr Pathobiol Rep       Date:  2013-06-01

Review 5.  Cancer stem cells in human digestive tract malignancies.

Authors:  Fatemeh B Rassouli; Maryam M Matin; Morvarid Saeinasab
Journal:  Tumour Biol       Date:  2015-10-07

6.  Variations in genes involved in dormancy associated with outcome in patients with resected colorectal liver metastases.

Authors:  S Stremitzer; W Zhang; D Yang; Y Ning; S Stintzing; Y Sunakawa; A Sebio; S Yamauchi; S Matsusaka; A Parekh; A Barzi; R El-Khoueiry; J Stift; F Wrba; T Gruenberger; H-J Lenz
Journal:  Ann Oncol       Date:  2015-05-08       Impact factor: 32.976

Review 7.  The role and mechanism of CRL4 E3 ubiquitin ligase in cancer and its potential therapy implications.

Authors:  Youzhou Sang; Fan Yan; Xiubao Ren
Journal:  Oncotarget       Date:  2015-12-15

8.  AA-NAT, MT1 and MT2 Correlates with Cancer Stem-Like Cell Markers in Colorectal Cancer: Study of the Influence of Stage and p53 Status of Tumors.

Authors:  Jorge Casado; Almudena Iñigo-Chaves; Sergio M Jiménez-Ruiz; Sandra Ríos-Arrabal; Ángel Carazo-Gallego; Cristina González-Puga; María Isabel Núñez; Ángeles Ruíz-Extremera; Javier Salmerón; Josefa León
Journal:  Int J Mol Sci       Date:  2017-06-11       Impact factor: 5.923

9.  Dual role of CD44 isoforms in ampullary adenocarcinoma: CD44s predicts poor prognosis in early cancer and CD44ν is an indicator for recurrence in advanced cancer.

Authors:  Cheng-Lin Wu; Ying-Jui Chao; Ta-Ming Yang; Yi-Ling Chen; Kung-Chao Chang; Hui-Ping Hsu; Yan-Shen Shan; Ming-Derg Lai
Journal:  BMC Cancer       Date:  2015-11-16       Impact factor: 4.430

10.  Prognostic impact of histological categorisation of epithelial-mesenchymal transition in colorectal cancer.

Authors:  H Ueno; E Shinto; Y Kajiwara; S Fukazawa; H Shimazaki; J Yamamoto; K Hase
Journal:  Br J Cancer       Date:  2014-09-23       Impact factor: 7.640
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