| Literature DB >> 30284958 |
Yanchun Liu1, Yijie Wang1, Jason Chakroff2, Jed Johnson2, Aidan Farrell1, Gail E Besner1,3.
Abstract
IMPACT STATEMENT: This study compared side-by-side the impact of donor age on the production of tissue-engineered small intestine (TESI). Each age represents a specific period of life: E18 for fetuses, 5-day-old pups for neonates, 21-day-old rats for weanlings, and 6-week-old rats for adults. The TESI produced was compared macroscopically and microscopically. The mechanism(s) contributing to the differences observed was explored by detecting proliferating cells in the TESI and by analyzing intestinal stem cell gene expression in donor cells. These data may provide valuable information for future application of TESI clinically.Entities:
Keywords: donor age; intestinal stem cells; tissue maturation; tissue-engineered small intestine
Mesh:
Year: 2018 PMID: 30284958 PMCID: PMC6590728 DOI: 10.1089/ten.TEA.2018.0226
Source DB: PubMed Journal: Tissue Eng Part A ISSN: 1937-3341 Impact factor: 3.845