Literature DB >> 30284958

Production of Tissue-Engineered Small Intestine in Rats with Different Ages of Cell Donors.

Yanchun Liu1, Yijie Wang1, Jason Chakroff2, Jed Johnson2, Aidan Farrell1, Gail E Besner1,3.   

Abstract

IMPACT STATEMENT: This study compared side-by-side the impact of donor age on the production of tissue-engineered small intestine (TESI). Each age represents a specific period of life: E18 for fetuses, 5-day-old pups for neonates, 21-day-old rats for weanlings, and 6-week-old rats for adults. The TESI produced was compared macroscopically and microscopically. The mechanism(s) contributing to the differences observed was explored by detecting proliferating cells in the TESI and by analyzing intestinal stem cell gene expression in donor cells. These data may provide valuable information for future application of TESI clinically.

Entities:  

Keywords:  donor age; intestinal stem cells; tissue maturation; tissue-engineered small intestine

Mesh:

Year:  2018        PMID: 30284958      PMCID: PMC6590728          DOI: 10.1089/ten.TEA.2018.0226

Source DB:  PubMed          Journal:  Tissue Eng Part A        ISSN: 1937-3341            Impact factor:   3.845


  30 in total

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5.  Lymphangiogenesis in tissue-engineered small intestine.

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9.  Transcriptome-wide Analysis Reveals Hallmarks of Human Intestine Development and Maturation In Vitro and In Vivo.

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10.  Generation of tissue-engineered small intestine using embryonic stem cell-derived human intestinal organoids.

Authors:  Stacy R Finkbeiner; Jennifer J Freeman; Minna M Wieck; Wael El-Nachef; Christopher H Altheim; Yu-Hwai Tsai; Sha Huang; Rachel Dyal; Eric S White; Tracy C Grikscheit; Daniel H Teitelbaum; Jason R Spence
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1.  A Comparison of Sterilization Techniques for Production of Decellularized Intestine in Mice.

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