Literature DB >> 22546272

Vitamin D receptor expression and neoadjuvant therapy in esophageal adenocarcinoma.

Ryan Trowbridge1, Poonam Sharma, William J Hunter, Devendra K Agrawal.   

Abstract

Esophageal adenocarcinoma carries a poor prognosis. Tumor response to neoadjuvant therapy is a key prognostic factor in patients with adenocarcinoma of the esophagus, but is inconsistent. Identifying tumor characteristics that portend a favorable response to neoadjuvant therapy would be a valuable clinical tool. The anticancer actions of vitamin D and its receptor may have implications. In this study, 15 biopsy specimens were procured retrospectively from patients being treated for adenocarcinoma of the esophagus. The tissue was immunostained for the vitamin D receptor and compared on the basis of response to neoadjuvant therapy. Tumors that did not respond to neoadjuvant therapy had greater expression of VDR than tumors that responded completely. Expression of VDR declined with tumor de-differentiation. The data suggest that a relationship between vitamin D receptor expression and response to neoadjuvant therapy is plausible.
Copyright © 2012 Elsevier Inc. All rights reserved.

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Year:  2012        PMID： 22546272      PMCID： PMC3400680          DOI： 10.1016/j.yexmp.2012.04.018

Source DB:  PubMed          Journal:  Exp Mol Pathol        ISSN： 0014-4800            Impact factor:   3.362


  33 in total

1.  Effect of histologic subtype on treatment and outcomes for esophageal cancer in the United States.

Authors:  Ryan P Merkow; Karl Y Bilimoria; Martin D McCarter; Warren B Chow; Howard S Gordon; Andrew K Stewart; Clifford Y Ko; David J Bentrem
Journal:  Cancer       Date:  2011-10-17       Impact factor: 6.860

2.  Expression of 1,25-dihydroxyvitamin D3 receptors in normal and psoriatic skin.

Authors:  P Milde; U Hauser; T Simon; G Mall; V Ernst; M R Haussler; P Frosch; E W Rauterberg
Journal:  J Invest Dermatol       Date:  1991-08       Impact factor: 8.551

3.  Expression of vitamin D receptor and 25-hydroxyvitamin D3-1{alpha}-hydroxylase in normal and malignant human colon.

Authors:  Damien Matusiak; Genoveva Murillo; Robert E Carroll; Rajendra G Mehta; Richard V Benya
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2005-10       Impact factor: 4.254

4.  Protein kinase C and mitogen-activated protein kinase are required for 1,25-dihydroxyvitamin D3-stimulated Egr induction.

Authors:  D W Beno; L M Brady; M Bissonnette; B H Davis
Journal:  J Biol Chem       Date:  1995-02-24       Impact factor: 5.157

5.  Analysis of 1,25-dihydroxyvitamin D(3) receptors (VDR) in basal cell carcinomas.

Authors:  J Reichrath; J Kamradt; X H Zhu; X F Kong; W Tilgen; M F Holick
Journal:  Am J Pathol       Date:  1999-08       Impact factor: 4.307

6.  Histomorphologic tumor regression and lymph node metastases determine prognosis following neoadjuvant radiochemotherapy for esophageal cancer: implications for response classification.

Authors:  Paul M Schneider; Stephan E Baldus; Ralf Metzger; Martin Kocher; Rudolf Bongartz; Elfriede Bollschweiler; Hartmut Schaefer; Juergen Thiele; Hans P Dienes; Rolf P Mueller; Arnulf H Hoelscher
Journal:  Ann Surg       Date:  2005-11       Impact factor: 12.969

7.  Evidence of 1,25-dihydroxyvitamin D3-receptors in human digestive mucosa and carcinoma tissue biopsies taken at different levels of the digestive tract, in 152 patients.

Authors:  F Meggouh; P Lointier; D Pezet; S Saez
Journal:  J Steroid Biochem       Date:  1990-06       Impact factor: 4.292

8.  Prognostic value of expression of ERCC1, thymidylate synthase, and glutathione S-transferase P1 for 5-fluorouracil/oxaliplatin chemotherapy in advanced gastric cancer.

Authors:  H-C Kwon; M S Roh; S Y Oh; S-H Kim; M C Kim; J-S Kim; H-J Kim
Journal:  Ann Oncol       Date:  2007-03       Impact factor: 32.976

9.  Extended transthoracic resection compared with limited transhiatal resection for adenocarcinoma of the esophagus.

Authors:  Jan B F Hulscher; Johanna W van Sandick; Angela G E M de Boer; Bas P L Wijnhoven; Jan G P Tijssen; Paul Fockens; Peep F M Stalmeier; Fiebo J W ten Kate; Herman van Dekken; Huug Obertop; Hugo W Tilanus; J Jan B van Lanschot
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10.  Expression of the bile acid receptor FXR in Barrett's esophagus and enhancement of apoptosis by guggulsterone in vitro.

Authors:  Andrea De Gottardi; Jean-Marc Dumonceau; Fabien Bruttin; Alain Vonlaufen; Isabelle Morard; Laurent Spahr; Laura Rubbia-Brandt; Jean-Louis Frossard; Winand N M Dinjens; Peter S Rabinovitch; Antoine Hadengue
Journal:  Mol Cancer       Date:  2006-10-20       Impact factor: 27.401
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  14 in total

Review 1.  Vitamin D and Gastrointestinal Cancers: A Narrative Review.

Authors:  Hemant Goyal; Abhilash Perisetti; M Rubayat Rahman; Avi Levin; Giuseppe Lippi
Journal:  Dig Dis Sci       Date:  2018-12-03       Impact factor: 3.199

2.  Vitamin D receptor expression in the mucosal tissue at the gastroesophageal junction.

Authors:  Ryan Trowbridge; Sumeet K Mittal; Poonam Sharma; William J Hunter; Devendra K Agrawal
Journal:  Exp Mol Pathol       Date:  2012-06-01       Impact factor: 3.362

Review 3.  Vitamin D and the epidemiology of upper gastrointestinal cancers: a critical analysis of the current evidence.

Authors:  Ryan Trowbridge; Sumeet K Mittal; Devendra K Agrawal
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2013-04-05       Impact factor: 4.254

Review 4.  Vitamin D and GI cancers: shedding some light on dark diseases.

Authors:  Laura Hargrove; Taylor Francis; Heather Francis
Journal:  Ann Transl Med       Date:  2014-01

Review 5.  Basis for molecular diagnostics and immunotherapy for esophageal cancer.

Authors:  Joe Abdo; Devendra K Agrawal; Sumeet K Mittal
Journal:  Expert Rev Anticancer Ther       Date:  2016-11-23       Impact factor: 4.512

6.  Vitamin D Receptor Polymorphisms Are Associated with Reduced Esophageal Vitamin D Receptor Expression and Reduced Esophageal Adenocarcinoma Risk.

Authors:  Vincent T Janmaat; Anouk Van De Winkel; Maikel P Peppelenbosch; Manon C W Spaander; André G Uitterlinden; Farzin Pourfarzad; Hugo W Tilanus; Agnieszka M Rygiel; Leon M G Moons; Pascal P Arp; Kausilia K Krishnadath; Ernst J Kuipers; Luc J W Van Der Laan
Journal:  Mol Med       Date:  2015-04-21       Impact factor: 6.354

7.  Polymorphisms of Genes Related to Function and Metabolism of Vitamin D in Esophageal Adenocarcinoma.

Authors:  Saurabh Singhal; Harit Kapoor; Saravanan Subramanian; Devendra K Agrawal; Sumeet K Mittal
Journal:  J Gastrointest Cancer       Date:  2019-12

Review 8.  Vitamin D and gastrointestinal cancer.

Authors:  Ashish Mahendra; Basanta Kumar Choudhury; Tamanna Sharma; Neha Bansal; Richa Bansal; Shivangi Gupta
Journal:  J Lab Physicians       Date:  2018 Jan-Mar

9.  Anti-tumor effects of an oncolytic adenovirus expressing hemagglutinin-neuraminidase of Newcastle disease virus in vitro and in vivo.

Authors:  Dongyun He; Lili Sun; Chang Li; Ningning Hu; Yuan Sheng; Zhifei Chen; Xiao Li; Baorong Chi; Ningyi Jin
Journal:  Viruses       Date:  2014-02-18       Impact factor: 5.048

Review 10.  Vitamin D in esophageal cancer: Is there a role for chemoprevention?

Authors:  Carol Rouphael; Afrin Kamal; Madhusudhan R Sanaka; Prashanthi N Thota
Journal:  World J Gastrointest Oncol       Date:  2018-01-15
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