PURPOSE: We performed a meta-analysis of Phase III randomized trials to compare treatment outcomes for early-stage breast cancer patients receivingadjuvant chemotherapy with sequential or concurrent anthracyclines and taxanes. METHODS: All Phase III randomized trials comparing adjuvant chemotherapy of sequential or concurrent anthracyclines and taxanes in early-stage breast cancer patients were considered eligible. A total of three trials that enrolled 8728 women were analyzed. A pooled analysis was accomplished and event-based risk ratios (RR) with 95% confidence intervals (95%CI) were derived. The significant differences in disease-free survival (DFS) and overall survival (OS) were explored. A heterogeneity test was applied as well. RESULTS: Among three eligible trials, significant differences in favor of sequential regimen were seen in DFS (RR: 0.90; 95%CI: 0.84 to 0.98; P=0.01) and in OS (RR: 0.88; 95%CI: 0.79 to 0.98; P=0.02). CONCLUSION: Considering all the available Phase III trials, sequential adjuvant chemotherapy for early breast cancer seems to add a significant benefit in both DFS and OS over concurrent regimens.
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PURPOSE: We performed a meta-analysis of Phase III randomized trials to compare treatment outcomes for early-stage breast cancerpatients receiving adjuvant chemotherapy with sequential or concurrent anthracyclines and taxanes. METHODS: All Phase III randomized trials comparing adjuvant chemotherapy of sequential or concurrent anthracyclines and taxanes in early-stage breast cancerpatients were considered eligible. A total of three trials that enrolled 8728 women were analyzed. A pooled analysis was accomplished and event-based risk ratios (RR) with 95% confidence intervals (95%CI) were derived. The significant differences in disease-free survival (DFS) and overall survival (OS) were explored. A heterogeneity test was applied as well. RESULTS: Among three eligible trials, significant differences in favor of sequential regimen were seen in DFS (RR: 0.90; 95%CI: 0.84 to 0.98; P=0.01) and in OS (RR: 0.88; 95%CI: 0.79 to 0.98; P=0.02). CONCLUSION: Considering all the available Phase III trials, sequential adjuvant chemotherapy for early breast cancer seems to add a significant benefit in both DFS and OS over concurrent regimens.
Authors: John Carpenter; Andres Forero; Carla I Falkson; Lisle M Nabell; Jennifer F De Los Santos; Helen Krontiras; Kirby I Bland; Yufeng Li; Sejong Bae Journal: South Med J Date: 2020-11 Impact factor: 0.954