Literature DB >> 22538384

Synthesis and characterization of novel zwitterionic lipids with pH-responsive biophysical properties.

Colin L Walsh1, Juliane Nguyen, Francis C Szoka.   

Abstract

We report the synthesis and biophysical characterization of a novel class of zwitterionic lipids (ZL) with head groups containing a 3° or 4° amine and carboxylate. ZL form stable liposomes that exhibit head group dependent, pH-responsive biophysical characteristics. These lipids may be suitable components for drug delivery applications due to their ease of synthesis and unique pH-dependent properties.

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Year:  2012        PMID： 22538384     DOI： 10.1039/c2cc31710a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  12 in total

1.  Liposome-like Nanostructures for Drug Delivery.

Authors:  Weiwei Gao; Che-Ming J Hu; Ronnie H Fang; Liangfang Zhang
Journal:  J Mater Chem B       Date:  2013-12-28       Impact factor: 6.331

2.  Flow arrest intra-arterial delivery of small TAT-decorated and neutral micelles to gliomas.

Authors:  Juliane Nguyen; Shaolie S Hossain; Johann R N Cooke; Jason A Ellis; Michael B Deci; Charles W Emala; Jeffrey N Bruce; Irving J Bigio; Robert M Straubinger; Shailendra Joshi
Journal:  J Neurooncol       Date:  2017-04-18       Impact factor: 4.130

3.  Cationizable lipid micelles as vehicles for intraarterial glioma treatment.

Authors:  Juliane Nguyen; Johann R N Cooke; Jason A Ellis; Michael Deci; Charles W Emala; Jeffrey N Bruce; Irving J Bigio; Robert M Straubinger; Shailendra Joshi
Journal:  J Neurooncol       Date:  2016-02-22       Impact factor: 4.130

4.  Non-Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co-Delivery of Cas9 mRNA and sgRNA.

Authors:  Jason B Miller; Shuyuan Zhang; Petra Kos; Hu Xiong; Kejin Zhou; Sofya S Perelman; Hao Zhu; Daniel J Siegwart
Journal:  Angew Chem Int Ed Engl       Date:  2016-12-16       Impact factor: 15.336

5.  Sulfated quaternary amine lipids: a new class of inverse charge zwitterlipids.

Authors:  Vincent J Venditto; Aaron Dolor; Aditya Kohli; Stefan Salentinig; Ben J Boyd; Francis C Szoka
Journal:  Chem Commun (Camb)       Date:  2014-08-21       Impact factor: 6.222

6.  Controlled nucleation of lipid nanoparticles.

Authors:  Juliane Nguyen; Colin L Walsh; J P Michael Motion; Emily K Perttu; Francis Szoka
Journal:  Pharm Res       Date:  2012-04-28       Impact factor: 4.200

7.  Synthesis, characterization, and evaluation of ionizable lysine-based lipids for siRNA delivery.

Authors:  Colin L Walsh; Juliane Nguyen; Matthew R Tiffany; Francis C Szoka
Journal:  Bioconjug Chem       Date:  2012-12-18       Impact factor: 4.774

8.  Membrane-destabilizing ionizable phospholipids for organ-selective mRNA delivery and CRISPR-Cas gene editing.

Authors:  Shuai Liu; Qiang Cheng; Tuo Wei; Xueliang Yu; Lindsay T Johnson; Lukas Farbiak; Daniel J Siegwart
Journal:  Nat Mater       Date:  2021-02-04       Impact factor: 47.656

9.  The Impact of Alkyl-Chain Purity on Lipid-Based Nucleic Acid Delivery Systems - Is the Utilization of Lipid Components with Technical Grade Justified?

Authors:  Dorota Pawlowska; Christopher Janich; Andreas Langner; Bodo Dobner; Christian Wölk; Gerald Brezesinski
Journal:  Chemphyschem       Date:  2019-07-23       Impact factor: 3.102

10.  Conjugation of Mannans to Enhance the Potency of Liposome Nanoparticles for the Delivery of RNA Vaccines.

Authors:  Roshan Goswami; Derek T O'Hagan; Roberto Adamo; Barbara C Baudner
Journal:  Pharmaceutics       Date:  2021-02-09       Impact factor: 6.321
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