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Literature DB >> 22538348

A general method for detecting protease activity via gelation and its application to artificial clotting.

Steven C Bremmer¹, Jing Chen, Anne J McNeil, Matthew B Soellner.

Abstract

A modular system for detecting protease activity via enzyme-triggered gel formation is described. Protease-specific recognition sequences are utilized to achieve enzyme specificity. Artificial blood clotting is demonstrated by activating endogenous thrombin to trigger gelation in fibrinogen-deficient blood plasma.

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Year: 2012 PMID： 22538348 PMCID： PMC3376645 DOI： 10.1039/c2cc31537h

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

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4. Enzyme-triggered gelation: targeting proteases with internal cleavage sites.

Authors: Steven C Bremmer; Anne J McNeil; Matthew B Soellner
Journal: Chem Commun (Camb) Date: 2014-02-18 Impact factor: 6.222

5. Dephosphorylation of D-peptide derivatives to form biofunctional, supramolecular nanofibers/hydrogels and their potential applications for intracellular imaging and intratumoral chemotherapy.

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